‘Extended resection lowers Lynch-related cancer risk'
Ahmedabad: A global research comprising of 8,438 patients suffering from
colorectal cancer
caused by
Lynch Syndrome
has indicated pathways for ensuring less chances recurrence.
Tired of too many ads? go ad free now
A cohort from Ahmedabad represented India in the study.
Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is the most common hereditary cancer condition that significantly increases the risk of developing colorectal cancer and other cancers.
The condition often affects multiple generations, and in the Indian context, some studies estimate the prevalence to be one in 300 persons.
More importantly, about 10-15% of colorectal cancers in India are caused by the condition compared to 2-10% in Western countries. The cancer has a high relapse rate of 17-50% in later stages.
The study, '
Metachronous Colorectal Cancer
Risks After Extended or
Segmental Resection
in MLH1, MSH2, and MSH6 Lynch Syndrome: Multicentre Study from the Prospective Lynch Syndrome Database,' was recently published in the British Journal of Surgery (BJS) by Oxford Academic.
One of the authors of the study is Dr Harsh Sheth from FRIGE Institute of Human Genetics, Ahmedabad.
"It is one of the biggest studies in connection with Lynch Syndrome, comprising over 65,000 person-year follow-ups and surgical data of 908 patients. The study started with the question of what is the best surgical approach after the first tumour – should the onco surgeons go for segmental resection or extended colectomy to reduce chances of relapse," said Dr Sheth.
Tired of too many ads? go ad free now
He added that the study's findings indicate an equal or higher risk of developing metachronous colorectal cancer for those who already have a history. It challenges the earlier notion that screening and resection are enough. "
Extended resection
significantly reduces the risk of metachronous cancer (across all Lynch Syndrome genes) compared to segmental resection. There is no survival benefit in either surgery group, but there are benefits in fewer operative procedures, reduced surveillance burden, and better quality of life," said Dr Sheth.
The take-home message, said experts, for the surgical guidelines is to ensure that if Lynch Syndrome is detected pre-operatively, the chances of metachronous cancer should be discussed.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Time of India
an hour ago
- Time of India
Gut health is the root cause of unexpected weight gain and cravings
Over the last few years, there has been increasing medical opinion that much of the body's health problems like weight gain and perpetual hunger could be originated in the stomach. For Indians with unexplained weight loss or gain in spite of regular food or measured portions, the solution could lie not in the food they eat but the way the body processes and digests it. The gut, or gastrointestinal tract, is inhabited by trillions of bacteria that comprise what's called the gut microbiome. This intricate community of microorganisms dictates everything from digestion and nutrient consumption to immunity, metabolism, and even mood. If this balance is disrupted a process called dysbiosis it can set off a sequence of metabolic and hormonal reactions that lead to weight gain, bloating, fatigue, and cravings for unhealthy foods. Here's how body weight is affected by gut health: 1. Gut bacteria and metabolism Some species of gut bacteria are responsible for the breakdown of food and its conversion to energy directly. Their imbalance slows down metabolism and leads to fat storage in the body even when calorie consumption is not higher. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Giao dịch CFD với công nghệ và tốc độ tốt hơn IC Markets Đăng ký Undo A non-diverse gut may also release fewer short-chain fatty acids, which are proven to suppress appetite and fat burning. 2. Effect on hunger hormones and cravings An unhealthy gut can elevate levels of ghrelin (the hunger hormone) and lower leptin (the satiety hormone), leaving individuals hungrier more frequently. This imbalance may result in constant cravings, particularly for sugar and processed foods a complaint that most Indian patients with unpredictable eating habits raise. 3. Role of antibiotics and processed foods The overuse of antibiotics, and even consumption of highly processed foods, can destroy the lining of the gut and eliminate beneficial bacteria. Self-medication and frequent use of antibiotics are extremely prevalent in India and lead to chronic digestive imbalances. 4. The stress connection Stress, which is widespread in Indian urban lifestyles, can modify gut microbiota and enhance inflammation. The gut-brain axis two-way communication between the digestive system and the brain — implies that stress has a direct effect on digestion and appetite regulation. How to Enhance Gut Health for Weight Management: - Boost dietary fiber with vegetables, fruits, and whole grain foods. - Eat fermented foods such as curd, buttermilk, idli, and dosa to restore good bacteria. - Don't overuse antibiotics. - Exercise daily and stress manage with yoga or meditation. - Take probiotics under medical supervision. Dr. Aravind Badiger, Technical Director, BDR Pharmaceuticals One step to a healthier you—join Times Health+ Yoga and feel the change
NDTV
2 hours ago
- NDTV
"May Not Look, Sound Like Us": Axiom-4 Mission Chief On Extraterrestrial Life
New Delhi: Likening a visit to the space station to a camping trip, former NASA astronaut and Axiom-4 mission commander Peggy Whitson said the orbital station has enough food, water and other supplies to sustain the daily lives of those on board. "We have wet towels that we can use every day to clean ourselves. And we have enough resources from food and water perspectives that we can provide for ourselves. So it isn't like going to some ultra-rich hotel spa or whatever. It is very much a bit of a camping trip. But it's a lot of fun," she told NDTV. Days ahead of the mission's June 10 launch, Dr Whitson said that the most "special part" would be the integration of her team of four with the seven astronauts already on board the International Space station (ISS). The orbital station, she said, is equivalent to inter-connected bus-sized modules of various sizes with four pull-up laboratories, a toilet, exercise hardware and life support systems. "There's actually a lot more space than you think. But obviously, by increasing the crew size by four, it will be a challenge for us to all integrate and work together," she said when asked if the ISS will become crowded when the Axiom-4 team enters it. Should the Axiom-4 mission launch be successful, Dr Whitson and her team members Group Captain Shubhanshu Shukla, European Space Agency project astronaut Slawosz Uznanski-Wisniewski of Poland, and Tibor Kapu of Hungary will be seen floating around the orbital lab amid its screens, plugs, wires, switches, pipes and knobs. But what she is confident of is life far beyond among the billions of galaxies that unfold outside the space station's portal windows. "I haven't seen any (extraterrestrial life) with my own eyes. But what I have seen is just billions and billions of stars. And this is just our little galaxy. And there's billions and billions of galaxies. And I know, I know there has to be other life out there, because it is so expansive. I'm sure it exists, it may not look or sound like us," Dr Whitson said. That, she said, is the what pushes the idea of exploration and drives the continuous development of technologies further and further to find out about life beyond Earth. Dr Whitson and her colleague Mr Shukla, who is called "Shux" by the team, will especially look at India from space. "All of planet Earth is beautiful. India is special as well. It's relatively easy to pick out India because of the geography. I'm looking forward to seeing it again," she said. The Axiom-4 mission will launch on June 10 at 5.52 pm IST on board SpaceX's Falcon-9 rocket from the Kennedy Space Centre in Florida. Mr Shukla will be the second Indian to travel to space four decades after Rakesh Sharma's iconic spaceflight onboard Russia's Soyuz spacecraft in 1984. Once docked, the astronauts plan to spend up to 14 days aboard the orbiting laboratory, conducting science, outreach, and commercial activities. The Axiom-4 astronauts will perform around 60 scientific studies and activities representing 31 countries during their 14-day stay at the ISS. Mr Shukla is set to conduct exclusive food and nutrition-related experiments developed under a collaboration between the Indian Space Research Organisation (ISRO) and the Department of Biotechnology (DBT), with support from NASA. The experiments aim to pioneer space nutrition and self-sustaining life support systems, vital for future long-duration space travel. ISRO has lined up a set of seven experiments for Mr Shukla, who will also participate in five joint studies planned by NASA for its human research programme. It has drawn up plans to focus on India-centric food for carrying out experiments on the ISS, including sprouting methi (Fenugreek) and moong (green gram) in microgravity conditions.
News18
3 hours ago
- News18
Mukesh Ambani Donates Rs 151 Crore To Alma Mater ICT Mumbai As 'Guru Dakshina'
Last Updated: Hailing professor MM Sharma, Ambani reminisced about how the first lecture he attended at UDCT by the former had motivated him Reliance Industries Chairman and Managing Director Mukesh Ambani on Saturday announced an unconditional grant of Rs 151 crore to his alma mater—Institute of Chemical Technology, Mumbai—from where he graduated in the 1970s. Ambani spent over three hours at ICT—which was back then called the University Department of Chemical Technology (UDCT)—at a function to publish professor MM Sharma's biography titled 'Divine Scientist'. Ambani, reminiscing about how the first lecture he attended at UDCT by Sharma motivated him, said Sharma later played the role of the quiet architect of India's economic reforms, impressing upon policymakers that the only way for India to grow was to unshackle Indian industry from license-permit-raj which will allow Indian players to build scale, reduce dependence on imports and compete globally. 'Like my father Dhirubhai Ambani, he had a burning desire to change Indian industry from scarcity to global leadership," said the RIL chairman, adding: 'These two bold visionaries believed that science and technology, in alliance with private entrepreneurship, would open the floodgates of prosperity." Crediting the rise of Indian chemical industry to Sharma's efforts, Ambani, in his speech, referred to him as 'a Rashtra Guru ─ a Guru of Bharat'. He then announced the unconditional grant of Rs 151 crore to ICT, according to the instructions of Sharma, terming it 'Guru Dakshina'. 'When he tells us something, we just listen. We don't think. He told me 'Mukesh you have to do something big for ICT, and I am very pleased to announce that for professor Sharma," Ambani said while referring to the grant. Sharma, who joined UDCT as a professor at 27, has dedicated over six decades to teaching and research. His former students, many of whom went on to become pioneers in Indian science, recalled his influence and humility. The event was held at ICT's Pidilite Hall and presided over by senior nuclear scientist Anil Kakodkar. Several eminent scientists, including Raghunath Mashelkar, J B Joshi, Aniruddha Pandit, and G D Yadav, paid tribute to Prof Sharma's legacy in education and science. First Published: June 07, 2025, 10:55 IST
