Latest news with #Shape
Daily Mirror
2 days ago
- Business
- Daily Mirror
'Fast and really easy' brow lamination kit costs less than one salon appointment
Shoppers have been praising this 'fast and really easy' to use £35 brow lamination kit that gets you three treatments for the price of one salon appointments Laminated brows are still one of the top beauty trends, especially during the summer when we're all favouring a more natural, softer approach to make up. However a single salon appointment to get them professionally done can typically cost anywhere between £35 and £50 depending on where you are, which quickly adds up if you're keeping on top of it every four to six weeks. Thankfully plenty of DIY kits have been springing up, including Mylee's latest launch, the Brow Wow Lamination Kit, which costs just £35 and gets you three applications in one package. Each application lasts up to four weeks, meaning you'll save yourself money on at least two salon appointments before needing to buy a new kit. As well as being cost effective, the Brow Wow Lamination Kit also saves you plenty of precious time. Not only can you do it without having to leave the house, but it only has three steps, which gives you fuller looking brows in minutes. Plus you don't need to worry about booking appointments or suddenly realising at the last minute that you need them done, as you can do them any time you want. The kit contains everything you need to create your laminated brows too, with an oil free cleanser, glue, lifting lotion, spoolies, a Y-shaped tool and fixing lotion. The whole process should take around 15 minutes from start to finish, including your 10-12 minutes processing time, making it perfect for a last minute fix before you head out. As it's a brand new launch, the Brow Wow Lamination Kit has currently only racked up two reviews, but they're both five star ratings. One shopper wrote: 'Fab! Really easy to use, no more salon trips!!' Whilst the other agreed: 'Best ever salon perfection' and added: 'Awesome love it all.' Of course Mylee isn't the only brand to launch its own at-home brow lamination kit, with the Nanobrow Lamination Kit similarly priced at £34. Each application with the Nanobrow kit lasts up to six weeks, however there's no mention of how many applications you'll be able to squeeze out of a single pack. You could also pick up the BY ELLIE Brow Shape for £15.99, which isn't a semi-permanent lamination kit like the others, but is a great way of getting the laminated look on a temporary basis. Whether you want to try it first to see if the style suits you, or you just like to be able to change up your brow shape on a whim, it's a great alternative.
Cosmopolitan
2 days ago
- Entertainment
- Cosmopolitan
The truth about why Biggest Loser's Bob Harper had a heart attack
Whether you watched the series when it was initially on TV or this is your first time hearing about it, everyone is talking about The Biggest Loser right now. And, that's no coincidence. Netflix's newest documentary – Fit for TV: The Reality of The Biggest Loser – takes a deep-dive into the programme that captured America's attention from 2004 to 2016, interviewing everyone from former contestants to coaches who appeared on the show. Speaking of which, one coach from The Biggest Loser who has been of particular interest is Bob Harper. More recently, you might recognise him from the third season of The Traitors US, but he first made a name for himself as a celebrity trainer before going on to coach contestants on The Biggest Loser and later present the show, too. All of that is great for Harper's career, but fans also had concerns after he faced a shocking medical scare in 2017. Here, we go into who Bob Harper is and how he – the apparent epitome of health – suffered a heart attack... After initially starting his career as a personal trainer to the stars (as well as appearing as an extra in a string of music videos), Bob Harper made his TV debut as a fitness coach on the first season of The Biggest Loser in 2004. He continued on the show as a trainer across 15 seasons, and also appeared in several of the show's spin-off workout DVDs. By 2015, he'd taken over presenting the hit series and made appearances on the first three seasons of The Biggest Loser Australia. Beyond The Biggest Loser, in 2010 Harper launched his own website through which subscribers could receive weight-loss coaching. The success of this online business led to the release of his own workout DVD series, followed by contributions to Shape magazine as well as high-profile speaking events. Taking all of the above into consideration, Harper sounds like a pretty healthy guy. It came as a shock, then, when at age 51 he suffered a heart attack while working out at the gym. This prompted many fans to query: how could someone so fit have such a major health scare? "I was in full cardiac arrest,'' Harper told TODAY just two months after the heart attack that almost claimed his life. "My heart stopped. Not to be dramatic, but I was dead. I was on that ground dead." The fitness coach went on to explain that he had suffered a 'widow maker' which has a survival rate of just 6%. As for how he survived, Harper credits the fast-thinking of those around him in the gym and the fact that there were two doctors nearby. A sudden cardiac arrest like the one Harper had stops the heart beating and blood is no longer pumped through the body or to the brain – this means death can occur within minutes. Thankfully, the quick-acting doctors performed CPR and used a defibrillator to keep him alive. "The fact that there were doctors in the gym when I had the heart attack saved my life," he said of what happened that day. Like fans, Harper said he was in disbelief at being told he'd had a heart attack when he woke up in hospital two days later. "It was hugely shocking for me,'' he said, going on to explain what caused the near-death event. "I've learned a lot about myself," the fitness expert added. "I've learned a lot about the fact that genetics played a part in this. It is so important to know your health." For context, Harper's mother died of a heart attack at 70 and his grandfather passed away from one as well. What's more, despite his life being very exercise-heavy, his cholesterol levels were revealed to be quite high. While genetics may have been the cause of Harper's heart attack, experts have credited his fitness levels as a reason for his survival – although, this is something he had to tone down in the aftermath. Unable to jump back into his former fitness routine, Harper turned to lower-intensity workouts, including yoga. He also took up cardio rehab three times a week, and swapped his usual "carnivore" diet for one that centred around plant-based ingredients, per NBC. Understandably describing his heart attack as "life-changing", Harper explained that, while terrifying, it gave him a new outlook on life. "I became so much more aware of how precious this life is and that life can turn on a dime and lights can go out before you know it," he told NBC. "I found that I'm much more appreciative and much more passionate. Once you've had a heart attack, and survive it, you're part of the club – the heart attack survivors club – you want to be able to get the message out to help people as much as you can." As Harper's case has shown, even if you live a well-balanced, active lifestyle, you are still at risk of having a heart attack. That's because, while regular exercise and a healthy diet can be generally beneficial for heart health, and reduce the risk of certain conditions, it doesn't eliminate that risk altogether. According to the NHS, coronary heart disease (CHD) is the leading cause of heart attacks, and your chance of developing it is increased by: smoking, a high-fat diet, diabetes, high cholesterol, high blood pressure (hypertension), and being overweight or obese. Genetics also play a role. "This means that if someone you are related to has or has had a condition [like CHD], you might be at risk of developing it too," explains The British Heart Foundation. That being said, "while you cannot change your family history, or your genetics, there are things you can do to reduce your risk of having a heart attack." These include staying active – like Harper – as well as maintaining a healthy weight and avoiding alcohol and tobacco products. All three episodes of the Fit for TV: The Reality of the Biggest Loser documentary will be available to stream on Netflix from Friday 15 August. Sign up to watch This article is not intended to be a substitute for professional medical advice or diagnosis. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Yahoo
16-05-2025
- Business
- Yahoo
Shape Therapeutics Presents Preclinical Data Highlighting Therapeutic Potential of RNA Editing and AAV Delivery Platforms at the American Society of Gene and Cell Therapy 28th Annual Meeting
Industry-leading RNA editing activity in the CNS of both mice and non-human primates highlights the broad applicability and therapeutic potential of the RNAfix® platform in CNS diseases Preclinical data showcases first demonstration of systemically delivered RNA editing in a primate brain, enabled by a blood-brain barrier (BBB) crossing AAV5 variant TruStable™ system demonstrates greatly increased scalability and consistency vs existing methods of AAV production across multiple serotypes SEATTLE, May 16, 2025 (GLOBE NEWSWIRE) -- Shape Therapeutics, a leader in RNA-based gene therapy, today announced that the Company presented data demonstrating the potential of its RNAfix® platform to restore protein function and reduce pathogenic proteins implicated in multiple neurological diseases, and to deliver the therapies efficiently with novel brain-targeting AAV capsids. The Company also presented data highlighting the versatility of its TruStable™ platform to achieve high quality vectors with improved process yield and consistency, resulting in overall reduced costs. These data were shared in multiple oral and poster presentations at the American Society of Gene and Cell Therapy (ASGCT) 28th Annual Meeting taking place in New Orleans, Louisiana, May 13-17, 2025. 'The preclinical data we presented at this year's ASGCT meeting further highlight our transformational genetic medicine and scalable manufacturing platforms,' said David Huss, Ph.D., CSO and acting CEO of Shape Therapeutics. 'We were particularly pleased to showcase our novel brain-penetrating capsids that represent the first demonstration of systemically delivered RNA editing in a primate brain, the highest primate neuronal targeting by a blood-brain barrier-crossing AAV variant and the highest targeting of the primate substantia nigra seen with any novel brain therapy. These data, coupled with the AAV vectors produced via our TruStable™ producer platform, underscore the high-value, low-cost potential of our gene therapy assets.' Key findings from the presentations at ASGCT include: AAV5-Based Capsid Variants: Novel AAV5-based capsids generated by Shape's platform efficiently cross the BBB of cynomolgus macaques after IV injection while showing extensive liver and DRG detargeting. Two capsids, SHP-DB1 and SHP-DB2, showed particularly strong delivery to deep brain regions, with payload expression observed in >96% of all neurons in the substantia nigra, the critical brain region in Parkinson's disease. SHP-DB1 and SHP-DB2 delivered efficient targeted RNA editing across the NHP brain from a single IV injection, with up to 88% editing observed in RNA from brain biopsies. Programmable RNA Editing in the CNS: Shape's RNAfix® platform uses guide RNAs (gRNAs) that harness the natural Adenosine deaminases acting on RNA (ADAR) enzyme to therapeutically edit sites in patient RNA. gRNAs engineered with AI for potency and specificity enable therapeutic levels of protein modulation in multiple CNS diseases, demonstrating the broad applicability and enormous therapeutic potential of the RNAfix® platform for CNS diseases. In a mouse model of Rett syndrome, gRNAs targeting the R168X mutation in the MECP2 gene achieved broad distribution throughout the brain following IV injection, enabling 52-69% editing of the target mRNA and restoring full-length MECP2 protein in ~39% of all cells. In a mouse model of neurodegenerative disease, RNAfix gRNAs achieved >70% reduction of targeted pathogenic protein in iPSC-derived glutamatergic neurons and >50% protein knockdown in the mouse brain following a single systemic AAV dose. In a third neurological disease, RNAfix gRNAs achieved >90% protein knockdown in human neurons and >60% knockdown in mouse brain. RNAfix is designed for a 'one-and-done' therapeutic approach, supported by full maintenance of high efficiency editing in the mouse brain one year post-dosing. TruStable™ AAV Manufacturing: Shape's fully stable AAV producer cell line platform, TruStable, was shown to generate higher quantities and quality of material than a traditional transient transfection method. TruStable™ production cell line produced ~15-fold more AAV with ~3-fold higher packaging percentage than the comparator triple transfection system, resulting in ~30-fold more material generated per cell culture volume after final purification. In-vitro potency results suggest that the TruStable™ derived material is ~2-fold as potent as triple transfection when comparing the upper asymptote of the 4PL dose response curve. The TruStable™ producer cell line can now efficiently produce multiple AAV serotypes by integrating Adenoviral L4 helper factor, which broadens the applicability of the platform and support high-titer, reproducible production of diverse AAV vectors. About Shape Therapeutics ShapeTX is an AI-driven genomic medicines company focused on creating curative and transformative medicines through its programmable RNA editing technology. By focusing on three differentiated pillars of value, ShapeTX utilizes its RNAfix® technology, targeted delivery system and TruStable™ manufacturing platform to advance a strong internal pipeline of RNA therapeutics across a wide range of diseases, including ABCA4-related diseases and neurological disorders. You can find us at and on LinkedIn and X. Investor Contact:Anne Marie FieldsPrecision Media Contact:info@ in to access your portfolio
Yahoo
16-05-2025
- Business
- Yahoo
Shape Therapeutics Presents Preclinical Data Highlighting Therapeutic Potential of RNA Editing and AAV Delivery Platforms at the American Society of Gene and Cell Therapy 28th Annual Meeting
Industry-leading RNA editing activity in the CNS of both mice and non-human primates highlights the broad applicability and therapeutic potential of the RNAfix® platform in CNS diseases Preclinical data showcases first demonstration of systemically delivered RNA editing in a primate brain, enabled by a blood-brain barrier (BBB) crossing AAV5 variant TruStable™ system demonstrates greatly increased scalability and consistency vs existing methods of AAV production across multiple serotypes SEATTLE, May 16, 2025 (GLOBE NEWSWIRE) -- Shape Therapeutics, a leader in RNA-based gene therapy, today announced that the Company presented data demonstrating the potential of its RNAfix® platform to restore protein function and reduce pathogenic proteins implicated in multiple neurological diseases, and to deliver the therapies efficiently with novel brain-targeting AAV capsids. The Company also presented data highlighting the versatility of its TruStable™ platform to achieve high quality vectors with improved process yield and consistency, resulting in overall reduced costs. These data were shared in multiple oral and poster presentations at the American Society of Gene and Cell Therapy (ASGCT) 28th Annual Meeting taking place in New Orleans, Louisiana, May 13-17, 2025. 'The preclinical data we presented at this year's ASGCT meeting further highlight our transformational genetic medicine and scalable manufacturing platforms,' said David Huss, Ph.D., CSO and acting CEO of Shape Therapeutics. 'We were particularly pleased to showcase our novel brain-penetrating capsids that represent the first demonstration of systemically delivered RNA editing in a primate brain, the highest primate neuronal targeting by a blood-brain barrier-crossing AAV variant and the highest targeting of the primate substantia nigra seen with any novel brain therapy. These data, coupled with the AAV vectors produced via our TruStable™ producer platform, underscore the high-value, low-cost potential of our gene therapy assets.' Key findings from the presentations at ASGCT include: AAV5-Based Capsid Variants: Novel AAV5-based capsids generated by Shape's platform efficiently cross the BBB of cynomolgus macaques after IV injection while showing extensive liver and DRG detargeting. Two capsids, SHP-DB1 and SHP-DB2, showed particularly strong delivery to deep brain regions, with payload expression observed in >96% of all neurons in the substantia nigra, the critical brain region in Parkinson's disease. SHP-DB1 and SHP-DB2 delivered efficient targeted RNA editing across the NHP brain from a single IV injection, with up to 88% editing observed in RNA from brain biopsies. Programmable RNA Editing in the CNS: Shape's RNAfix® platform uses guide RNAs (gRNAs) that harness the natural Adenosine deaminases acting on RNA (ADAR) enzyme to therapeutically edit sites in patient RNA. gRNAs engineered with AI for potency and specificity enable therapeutic levels of protein modulation in multiple CNS diseases, demonstrating the broad applicability and enormous therapeutic potential of the RNAfix® platform for CNS diseases. In a mouse model of Rett syndrome, gRNAs targeting the R168X mutation in the MECP2 gene achieved broad distribution throughout the brain following IV injection, enabling 52-69% editing of the target mRNA and restoring full-length MECP2 protein in ~39% of all cells. In a mouse model of neurodegenerative disease, RNAfix gRNAs achieved >70% reduction of targeted pathogenic protein in iPSC-derived glutamatergic neurons and >50% protein knockdown in the mouse brain following a single systemic AAV dose. In a third neurological disease, RNAfix gRNAs achieved >90% protein knockdown in human neurons and >60% knockdown in mouse brain. RNAfix is designed for a 'one-and-done' therapeutic approach, supported by full maintenance of high efficiency editing in the mouse brain one year post-dosing. TruStable™ AAV Manufacturing: Shape's fully stable AAV producer cell line platform, TruStable, was shown to generate higher quantities and quality of material than a traditional transient transfection method. TruStable™ production cell line produced ~15-fold more AAV with ~3-fold higher packaging percentage than the comparator triple transfection system, resulting in ~30-fold more material generated per cell culture volume after final purification. In-vitro potency results suggest that the TruStable™ derived material is ~2-fold as potent as triple transfection when comparing the upper asymptote of the 4PL dose response curve. The TruStable™ producer cell line can now efficiently produce multiple AAV serotypes by integrating Adenoviral L4 helper factor, which broadens the applicability of the platform and support high-titer, reproducible production of diverse AAV vectors. About Shape Therapeutics ShapeTX is an AI-driven genomic medicines company focused on creating curative and transformative medicines through its programmable RNA editing technology. By focusing on three differentiated pillars of value, ShapeTX utilizes its RNAfix® technology, targeted delivery system and TruStable™ manufacturing platform to advance a strong internal pipeline of RNA therapeutics across a wide range of diseases, including ABCA4-related diseases and neurological disorders. You can find us at and on LinkedIn and X. Investor Contact:Anne Marie FieldsPrecision Media Contact:info@
Yahoo
01-05-2025
- Yahoo
CT man accused of killing former mother-in-law with baseball bat blamed her for failed marriage
A man accused of killing his former mother-in-law during a vicious attack with a baseball bat outside an apartment building in Trumbull on Monday allegedly told investigators that he blamed the woman for his failed marriage and the financial difficulties that followed, according to the police report. Ylli Shtopaju, 45, of Norwalk faces one count of murder in the killing of 70-year-old Lida Shape after investigators found that he followed her from the Trumbull Mall to the Ten Trumbull Apartments at 100 Oakview Dr. where she lived with his ex-wife and the former couple's children, according to the report filed by investigators with the Trumbull Police Department. Police believe Shtopaju approached Shape and a relative who was with her after the two had been dropped off by an Uber driver outside the apartments, the report said. He allegedly got their attention outside the building, but the pair turned their backs and ignored him as they walked toward the entrance, according to the report. During an interview with detectives, Shtopaju allegedly admitted to retrieving a baseball bat from the trunk of his Mercedes Benz and jogging toward Shape, the report said. He allegedly raised the bat in the air and swung it down on top of Shape's head, according to the report. Police said he then allegedly spent the next 90 seconds striking her with the bat before dropping it and walking nearby where he waited for police to arrive. Shtopaju allegedly told police Shape 'tried to kill me for all my life, so I did it today,' the report said. Police responded to the apartment building shortly after 12:30 p.m. on Monday after multiple 911 callers reported that a man was beating a woman with a bat, according to the report. Numerous officers responded and found Shape lying on her back, having been viciously beaten and gasping for air, the report said. A black baseball bat was found on the ground nearby. As police were tending to Shape, a witness from the fourth-floor balcony yelled out to police 'that's him' while pointing at Shtopaju, who was approaching officers and trying to wave them down, the report said. An officer immediately noticed that he had apparent blood droplets covering his shoes and took him into custody after he allegedly admitted to attacking Shape, police wrote. Police tending to Shape performed life-saving measures and noted that she was experiencing agonal breathing and a faint pulse that soon faded. She also had portions of the back of her skull caved in, the report said. Officers attached an automated external defibrillator to Shape, but the device gave them a 'no shock advised' message. Police administered CPR until medics arrived and discussed whether they should abandon their life-saving efforts, police wrote in the report. Shape was pronounced dead at 12:55 p.m. Investigators secured the scene, took a number of photos and interviewed numerous witnesses, the report said. They also viewed video surveillance footage from the building and spoke to Shtopaju after he agreed to an interview with detectives at the police station. Shtopaju explained to investigators that he is divorced from his ex-wife and that she lives at the apartment building along with their two children and her mother, the report said. He allegedly told police he blamed Shape for the failed marriage, for the loss of his house in Monroe and 'the fact that he currently does not have any money,' the report said. Shtopaju said he was at the mall ordering food from the food court for when his children got out of school when he noticed Shape and a relative who lives out of state, according to the report. Shtopaju claimed that he made eye contact with Shape but they did not say anything to one another, the report said. Shtopaju allegedly admitted to detectives that he followed Shape and her relative as they left the mall and got into a vehicle that picked them up and brought them to the apartment building, the report said. He allegedly said he retrieved the bat when she tried walking away from him after trying to confront her, according to the report. Shtopaju allegedly told police that as he struck Shape with the bat he told her she 'has killed him his whole life' and that he 'has killed her once,' the report said. Video surveillance showed that Shape was knocked to the ground after the first hit from the bat, the report said. The relative who was with her watched for a few seconds before running to safety. Shtopaju allegedly could be seen in the footage striking Shape a number of times 'using a combination of overhead, swinging down strikes' along with several sideways 'golf club' style swings, the report said. Shtopaju was held in custody overnight on $3 million bond and was arraigned on Tuesday in Bridgeport Superior Court. Court records show he did not immediately post his bail, which a judge did not change during his arraignment. Shtopaju did not enter a plea during the hearing and is being represented by a public defender, records show. He is due back in court on Friday.
