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Daily Mirror
6 days ago
- Daily Mirror
'Hidden European gem' is 'world's most liveable city' and great for cycling
A study from Oxford Economics has named the 10 top cities offering to the highest quality of life to residents, and the top spot goes to a gem in the French Alps A study from Oxford Economics has revealed the most liveable cities around the globe - with the number one spot going to a hidden treasure in Western Europe. The top ranking city was highlighted for its walkability, cycling paths and overall quality of life. In 2024, the Global Cities Index evaluated numerous cities to name the " most liveable destination" in the world. The study took into consideration six crucial criteria: life expectancy, income per person, income equality, recreational and cultural sites, internet speed, and housing costs. Every city in the top 10 list is located in Western Europe, with the exception of one Australian city. According to Oxford Economics, the cities at the top of the Quality of Life category are those with lower inequality and residents that live long lives. It comes after a British man claimed 'I moved from UK to Benidorm – price of a pint and Full English left me floored'. 10) Nantes Located in western France, Nantes is known for its rich history, cultural attractions, and urban life. One must-visit destination is the Château des Ducs de Bretagne which houses the Nantes History Museum. It sheds light on the city's medieval past and features well-preserved architecture and exhibitions. 9) Ghent Ghent in Belgium is well-known for its medieval charm, cultural scene, and architecture. It is also the most walkable town in the country. Ghent's canal side streets are lined with historical buildings and are perfect for a leisurely and picturesque stroll. 8) Zurich Zurich - Switzerland's largest city - has earned an impressive global reputation for its high quality of life and stunning natural surroundings. Locals and visitors can enjoy walks along the shores of Lake Zurich, enjoy delicious cheese and relax in one of the lakeside parks. 7) Reykjavik A booming tourist destination, the Icelandic capital of Reykjavik is one of the world's best places to live. Tjörnin, a pond located in the heart of Reykjavik, is surrounded by charming buildings and is a great spot for a relaxing walk. 6) Luxembourg Luxembourg, the capital of the eponymous country, is known for its low crime rates and exceptionally clean streets. These factors have created a distinct sense of safety and well-being for its residents. Luxembourg City also has an efficient and comprehensive public transportation network and the introduction of free public transport has only enhanced accessibility. 5) Basel The Swiss city of Basel is lauded for its practical, high-quality living conditions. The city also provides excellent healthcare services with renowned medical facilities such as the University Hospital Basel, known for its cutting-edge treatments. 4) Bergen Bergen, in Norway, is renowned for its breathtaking natural scenery, including fjords, mountains, and coastal landscapes. The city offers numerous outdoor activities, from hiking in the surrounding mountains like Mount Fløyen and Mount Ulriken to sailing and kayaking in the fjords. The city is known for its safety, cleanliness, and low crime rates. 3) Bern The Swiss capital city of Bern boasts historic charm and modern-day conveniences. The city's medieval old town is a UNESCO World Heritage site and landmarks like the Zytglogge clock tower and the Bear Park contribute to its unique atmosphere. Bern is also known for its low crime rate and exceptional infrastructure. 2) Canberra The only non-European city on the ranking, Australia's capital city of Canberra is a standout for its natural beauty and intuitive urban design. Canberra is known for its high standard of living, with clean and safe environments, well-maintained public spaces, and efficient public services. As of 2024, the city also has one of the highest life expectancy rates in the world and high levels of income per person. 1) Grenoble A gem located in the French Alps, Grenoble has the ultimate combination of natural beauty, vibrant cultural life, and high quality of life. The city has become a hub for scientific research and technological innovation, but is also a model of urban design. Grenoble is known for its bike-friendly initiatives, including comprehensive bike lanes and rental services.
Associated Press
05-02-2025
- Health
- Associated Press
Clot-buster meds & mechanical retrieval equally reduce disability from some strokes
Research Highlights: Mechanically retrieving a blood clot blocking a medium- or small-sized brain artery was no better at reducing disability 90 days after a stroke than standard care alone (including clot-busting medication if indicated). While researchers say using thrombectomy devices to remove blood clots is increasingly performed, this research suggests that it may not be needed in all cases. However, because endovascular therapy seemed to be safe, it might still be used on select patients. Note: The study featured in this news release is a research abstract. Abstracts presented at the American Heart Association ' s scientific meetings are not peer-reviewed, and the findings are considered preliminary until published as full manuscripts in a peer-reviewed scientific journal. Embargoed until 11:59 a.m. PT/2:59 p.m. ET Wednesday, Feb. 5, 2025 ( NewMediaWire) - February 05, 2025 - LOS ANGELES — Removing a clot blocking a medium- or small-sized artery in the brain mechanically is a safe treatment for a common type of stroke; however, it did not lessen disability more than best medical treatment (including clot-busting medication if indicated) alone, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2025. The conference, in Los Angeles, Feb. 5-7, 2025, is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. An estimated 20-40% of people with ischemic (clot-caused) stroke have a clot blocking one of several medium- or small-sized arteries above the base of the brain (called a medium distal vessel occlusion, or MDVO), explained lead study author Marios Psychogios, M.D. head of diagnostic and interventional neuroradiology at the University Hospital Basel in Switzerland. 'Given the high and rising prevalence of ischemic strokes in aging populations, stroke in medium distal vessels represents a significant and growing health concern,' he said. 'While these strokes were traditionally thought to have a favorable prognosis, findings from recent studies suggest that only half of people regain functional independence, underscoring the urgent need for more effective treatments.' Endovascular therapy is a minimally invasive procedure that uses catheters over which a stent-retriever and/or aspiration catheter is advanced to the occlusion in the brain to retrieve the clot and restore blood flow, preventing further brain damage. The American Heart Association/American Stroke Association 2019 Guidelines for the Early Management of Patients with Acute Ischemic Stroke recommends mechanical clot removal within 24 hours of symptom onset for selected patients with clots blocking large arteries. For clots blocking medium vessels, the Association notes that 'although the benefits are uncertain, the use of mechanical thrombectomy with stent retrievers may be reasonable' for carefully selected ischemic stroke patients within six hours of symptom onset. The DISTAL trial, launched in 2021, is investigating whether endovascular therapy in addition to best medical therapy — which often includes intravenous clot-busting medications — would reduce disability more than clot-busting treatment alone. The trial included 543 adult patients who entered one of 55 hospitals with disabling stroke symptoms. Imaging tests confirmed a medium distal vessel blockage in all participants. Participants were randomly selected to receive either standard stroke care with intravenous clot-busting medication if deemed eligible or standard stroke care/intravenous clot busters plus endovascular treatment to remove the clot. The effectiveness of the treatment was measured by the participant's disability and need for assistance in daily activities 90 days after the stroke. At the 90-day follow-up, the analysis found: No significant difference in disability in those receiving endovascular therapy plus standard medical care and those receiving standard medical care alone. Similar rates of death were noted for each group: 15.5% for those receiving endovascular therapy plus standard medical care vs. 14% among those receiving standard medical care alone. Rates of severe (symptomatic) brain bleeds were 5.9% for those receiving endovascular therapy plus standard medical care vs. 2.6% for standard medical care alone. 'Endovascular therapy with the current techniques may not always provide extra benefits, so it could be worth reconsidering it as the standard treatment for medium distal vessel blockages. However, it is a safe option that can still be considered for select people on a case-by-case basis,' said Urs Fischer, M.D. co-principal investigator of the DISTAL trial and director of neurology at the University Hospital Bern in Switzerland. The lack of added benefit was confirmed when researchers analyzed specific subsets of people, such as those who did not receive intravenous clot-busting medications and those who had more severe strokes. Some people may not receive clot-busting medications because these medications can be harmful to them. 'We were surprised at the overall outcome of the participants, which was worse than we anticipated based on retrospective data,' Psychogios said. The researchers are currently conducting a detailed analysis of whether endovascular therapy was more or less effective in different subgroups of participants, perhaps enabling them to identify characteristics that might be associated with a more positive outcome following the treatment. Because almost all participants in the study were white, the results may not be generalizable to other populations. While the study's design offered the benefit of looking at the real-world application of mechanical clot removal, it may have limited the researchers' ability to detect positive effects from it that would have been apparent in a more selective patient group, both researchers agree. In addition, physicians who already believed that endovascular therapy was a superior treatment might have treated patients with endovascular therapy outside of the trial rather than taking the chance that their patients might be randomized to standard medical treatment alone. 'While the results of the DISTAL trial might seem discouraging, we see it as a wakeup call to continue investigating treatment options for medium or distal vessel occlusion patients as outcomes appear to be more severe than expected and evidence-based effective treatment options are still lacking,' Psychogios said. Study details, background and design: The DISTAL (EnDovascular therapy plus best medical treatment (BMT) versus BMT alone for MedIum VeSsel Occlusion sTroke -- a prAgmatic, international, multicenter, randomized triaL) study enrolled patients between December 2021 and July 2024, with the final assessment completed in October 2024. The study was conducted at 55 sites in Switzerland, Germany, Belgium, Spain, Portugal, Italy, Netherlands, Sweden, Israel, Finland and the United Kingdom. The study included 543 patients (44% women, average age 75 years, 98% white) who experienced a clot-caused stroke located in one of the medium- or small-sized arteries in the brain. Before the stroke, 97.9% of the participants lived at home. About 63% had no disability before the stroke, 17% had symptoms but could independently carry out their usual activities, 11.5% could not do all activities but could look after their affairs without assistance, and 8% required assistance for walking and other needs. Imaging tests were conducted on all patients to confirm they could be treated within 24 hours of symptom onset. During imaging, blockages were visualized mainly in the M2 (44%) or M3 (27%) segments of the middle cerebral artery or in the P2 (14%) or P1 (6%) segment of the posterior cerebral artery. Stroke severity at hospital admission was moderate, with a median score of 6 on the 42-point National Institutes of Health Stroke Scale. Participants were randomized to receive either best medical treatment at a dedicated stroke center, including clot-busting medication if indicated (272 participants out of which 66% received clot-busting drugs) or best medical treatment plus endovascular treatment (271 participants). Decisions about the exact devices and procedures used for endovascular treatment were left to the treating physician. Participants were excluded if they had a brain bleed, other severe medical conditions, or previous treatment or anatomical features that made endovascular treatment unlikely to be successful. The primary outcome was the degree of disability and need for help in daily activities 90 days after the stroke, as measured with the modified Rankin Scale with ratings from 0 (no disability) to 6 (death). Disability was assessed by someone unaware of the treatment received. Study co-authors, funding and disclosures are available in the abstract. Statements and conclusions of studies that are presented at the American Heart Association's scientific meetings are solely those of the study authors and do not necessarily reflect the Association's policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. Abstracts presented at the Association's scientific meetings are not peer-reviewed, rather, they are curated by independent review panels and are considered based on the potential to add to the diversity of scientific issues and views discussed at the meeting. The findings are considered preliminary until published as a full manuscript in a peer-reviewed scientific journal. The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers and the Association's overall financial information are available here. About the American Stroke Association The American Stroke Association is devoted to saving people from stroke — the No. 2 cause of death in the world and a leading cause of serious disability. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat stroke. The Dallas-based association officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit Facebook, X.
