logo
Clot-buster meds & mechanical retrieval equally reduce disability from some strokes

Clot-buster meds & mechanical retrieval equally reduce disability from some strokes

Research Highlights:
Mechanically retrieving a blood clot blocking a medium- or small-sized brain artery was no better at reducing disability 90 days after a stroke than standard care alone (including clot-busting medication if indicated).
While researchers say using thrombectomy devices to remove blood clots is increasingly performed, this research suggests that it may not be needed in all cases.
However, because endovascular therapy seemed to be safe, it might still be used on select patients.
Note: The study featured in this news release is a research abstract. Abstracts presented at the American Heart Association ' s scientific meetings are not peer-reviewed, and the findings are considered preliminary until published as full manuscripts in a peer-reviewed scientific journal.
Embargoed until 11:59 a.m. PT/2:59 p.m. ET Wednesday, Feb. 5, 2025
( NewMediaWire) - February 05, 2025 - LOS ANGELES — Removing a clot blocking a medium- or small-sized artery in the brain mechanically is a safe treatment for a common type of stroke; however, it did not lessen disability more than best medical treatment (including clot-busting medication if indicated) alone, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2025. The conference, in Los Angeles, Feb. 5-7, 2025, is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health.
An estimated 20-40% of people with ischemic (clot-caused) stroke have a clot blocking one of several medium- or small-sized arteries above the base of the brain (called a medium distal vessel occlusion, or MDVO), explained lead study author Marios Psychogios, M.D. head of diagnostic and interventional neuroradiology at the University Hospital Basel in Switzerland.
'Given the high and rising prevalence of ischemic strokes in aging populations, stroke in medium distal vessels represents a significant and growing health concern,' he said. 'While these strokes were traditionally thought to have a favorable prognosis, findings from recent studies suggest that only half of people regain functional independence, underscoring the urgent need for more effective treatments.'
Endovascular therapy is a minimally invasive procedure that uses catheters over which a stent-retriever and/or aspiration catheter is advanced to the occlusion in the brain to retrieve the clot and restore blood flow, preventing further brain damage.
The American Heart Association/American Stroke Association 2019 Guidelines for the Early Management of Patients with Acute Ischemic Stroke recommends mechanical clot removal within 24 hours of symptom onset for selected patients with clots blocking large arteries. For clots blocking medium vessels, the Association notes that 'although the benefits are uncertain, the use of mechanical thrombectomy with stent retrievers may be reasonable' for carefully selected ischemic stroke patients within six hours of symptom onset.
The DISTAL trial, launched in 2021, is investigating whether endovascular therapy in addition to best medical therapy — which often includes intravenous clot-busting medications — would reduce disability more than clot-busting treatment alone.
The trial included 543 adult patients who entered one of 55 hospitals with disabling stroke symptoms. Imaging tests confirmed a medium distal vessel blockage in all participants. Participants were randomly selected to receive either standard stroke care with intravenous clot-busting medication if deemed eligible or standard stroke care/intravenous clot busters plus endovascular treatment to remove the clot.
The effectiveness of the treatment was measured by the participant's disability and need for assistance in daily activities 90 days after the stroke.
At the 90-day follow-up, the analysis found:
No significant difference in disability in those receiving endovascular therapy plus standard medical care and those receiving standard medical care alone.
Similar rates of death were noted for each group: 15.5% for those receiving endovascular therapy plus standard medical care vs. 14% among those receiving standard medical care alone.
Rates of severe (symptomatic) brain bleeds were 5.9% for those receiving endovascular therapy plus standard medical care vs. 2.6% for standard medical care alone.
'Endovascular therapy with the current techniques may not always provide extra benefits, so it could be worth reconsidering it as the standard treatment for medium distal vessel blockages. However, it is a safe option that can still be considered for select people on a case-by-case basis,' said Urs Fischer, M.D. M.Sc., co-principal investigator of the DISTAL trial and director of neurology at the University Hospital Bern in Switzerland.
The lack of added benefit was confirmed when researchers analyzed specific subsets of people, such as those who did not receive intravenous clot-busting medications and those who had more severe strokes. Some people may not receive clot-busting medications because these medications can be harmful to them.
'We were surprised at the overall outcome of the participants, which was worse than we anticipated based on retrospective data,' Psychogios said.
The researchers are currently conducting a detailed analysis of whether endovascular therapy was more or less effective in different subgroups of participants, perhaps enabling them to identify characteristics that might be associated with a more positive outcome following the treatment.
Because almost all participants in the study were white, the results may not be generalizable to other populations. While the study's design offered the benefit of looking at the real-world application of mechanical clot removal, it may have limited the researchers' ability to detect positive effects from it that would have been apparent in a more selective patient group, both researchers agree. In addition, physicians who already believed that endovascular therapy was a superior treatment might have treated patients with endovascular therapy outside of the trial rather than taking the chance that their patients might be randomized to standard medical treatment alone.
'While the results of the DISTAL trial might seem discouraging, we see it as a wakeup call to continue investigating treatment options for medium or distal vessel occlusion patients as outcomes appear to be more severe than expected and evidence-based effective treatment options are still lacking,' Psychogios said.
Study details, background and design:
The DISTAL (EnDovascular therapy plus best medical treatment (BMT) versus BMT alone for MedIum VeSsel Occlusion sTroke -- a prAgmatic, international, multicenter, randomized triaL) study enrolled patients between December 2021 and July 2024, with the final assessment completed in October 2024.
The study was conducted at 55 sites in Switzerland, Germany, Belgium, Spain, Portugal, Italy, Netherlands, Sweden, Israel, Finland and the United Kingdom.
The study included 543 patients (44% women, average age 75 years, 98% white) who experienced a clot-caused stroke located in one of the medium- or small-sized arteries in the brain. Before the stroke, 97.9% of the participants lived at home. About 63% had no disability before the stroke, 17% had symptoms but could independently carry out their usual activities, 11.5% could not do all activities but could look after their affairs without assistance, and 8% required assistance for walking and other needs.
Imaging tests were conducted on all patients to confirm they could be treated within 24 hours of symptom onset. During imaging, blockages were visualized mainly in the M2 (44%) or M3 (27%) segments of the middle cerebral artery or in the P2 (14%) or P1 (6%) segment of the posterior cerebral artery.
Stroke severity at hospital admission was moderate, with a median score of 6 on the 42-point National Institutes of Health Stroke Scale.
Participants were randomized to receive either best medical treatment at a dedicated stroke center, including clot-busting medication if indicated (272 participants out of which 66% received clot-busting drugs) or best medical treatment plus endovascular treatment (271 participants).
Decisions about the exact devices and procedures used for endovascular treatment were left to the treating physician. Participants were excluded if they had a brain bleed, other severe medical conditions, or previous treatment or anatomical features that made endovascular treatment unlikely to be successful.
The primary outcome was the degree of disability and need for help in daily activities 90 days after the stroke, as measured with the modified Rankin Scale with ratings from 0 (no disability) to 6 (death). Disability was assessed by someone unaware of the treatment received.
Study co-authors, funding and disclosures are available in the abstract.
Statements and conclusions of studies that are presented at the American Heart Association's scientific meetings are solely those of the study authors and do not necessarily reflect the Association's policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. Abstracts presented at the Association's scientific meetings are not peer-reviewed, rather, they are curated by independent review panels and are considered based on the potential to add to the diversity of scientific issues and views discussed at the meeting. The findings are considered preliminary until published as a full manuscript in a peer-reviewed scientific journal.
The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers and the Association's overall financial information are available here.
About the American Stroke Association
The American Stroke Association is devoted to saving people from stroke — the No. 2 cause of death in the world and a leading cause of serious disability. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat stroke. The Dallas-based association officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit stroke.org Facebook, X.
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

I sit at a desk all day, and this is the 1 kettlebell exercise I swear by to boost my upper body mobility and build shoulder strength
I sit at a desk all day, and this is the 1 kettlebell exercise I swear by to boost my upper body mobility and build shoulder strength

Yahoo

time12 hours ago

  • Yahoo

I sit at a desk all day, and this is the 1 kettlebell exercise I swear by to boost my upper body mobility and build shoulder strength

When you buy through links on our articles, Future and its syndication partners may earn a commission. I remember leaning against the wall of my old gym at the end of a long work week, moaning to a PT about how tight and uncomfortable my shoulders felt after hours at my desk. She nodded knowingly, as many of her clients who work desk jobs complain of the same thing, and recommended one simple kettlebell exercise I had to try: the kettlebell halo. I took her advice and have been doing it ever since. For this exercise, I use the Bowflex adjustable kettlebell, one of the best kettlebells on the market if you want to train with weight without needing a full set of kettlebells. It lets you quickly adjust the weight depending on whether you're focusing on mobility with lighter rotations or adding a bit of strength work with a heavier load. The Bowflex SelectTech 840 is an adjustable kettlebell that goes from 8 to 40 pounds, letting you change the weight easily with a dial. You can also connect it to the JRNY app for guided workouts and training Deal How to do kettlebell halos To begin with use a very light kettlebell you can comfortably hold above your head and move in a controlled circle without straining your shoulders. Hold the kettlebell upside down by the sides of the handle close to your chest. Keep your core engaged and elbows slightly tucked. Slowly rotate the kettlebell in a circle around your head, moving clockwise for six to eight reps. Switch directions and perform the same number of counterclockwise rotations. The kettlebell halo really is a simple move with big benefits. It helps your shoulders move more freely by gently taking the joint through a full range of motion. At the same time, it strengthens the small stabilizing muscles around your shoulders, which are essential for keeping them healthy and pain-free. I love that it also works your upper back, traps, triceps, and core, so even a few minutes feels like a mini upper-body workout. When I'm consistent with this move, I can feel my shoulders loosen up and notice it's easier to maintain good posture at my desk. Sitting upright for long stretches feels more comfortable, and I'm less likely to slump or hunch by mid-afternoon. It also makes simple daily tasks, like reaching for items on a shelf or carrying a laptop bag, feel easier on my shoulders. As it's a low-impact move, halos are also perfect for warming up the upper body before a larger strength session or as an easy recovery exercise. Doing a few controlled rotations before a press, a row, or even a casual household task helps prevent tension from building up throughout the day. What I especially like about the kettlebell halo is that it's not about heavy lifting or building a certain physique. I use it purely to support my upper body strength and shoulder mobility, rather than chasing aesthetics. That means I don't worry about gradually increasing the weight or lifting heavier each week. The focus is on control, range of motion, and keeping my shoulders healthy, which makes it low-pressure and easy to fit into my daily routine. Follow Tom's Guide on Google News to get our up-to-date news, how-tos, and reviews in your feeds. Make sure to click the Follow button. More from Tom's Guide I wear these Sweaty Betty running shorts so much I need a pair for every day of the week — luckily they're 53% off right now Here are 7 ways I get the most out of my Garmin watch when training for a race Here's how to beat burnout — study finds the ideal amount of daily exercise to boost your mood

New blood pressure guidelines: What we know about the American Heart Association's updates
New blood pressure guidelines: What we know about the American Heart Association's updates

Yahoo

time21 hours ago

  • Yahoo

New blood pressure guidelines: What we know about the American Heart Association's updates

The American Heart Association and the American College of Cardiology issued a new set of guidelines to help minimize high blood pressure, also known as hypertension, on Aug. 14. The new guidelines are the first set published since 2017. Updates include instruction for doctors to recommend treatment to those with Stage 1 hypertension rather than just Stage 2, and the recommendation that Americans limit the amount of alcohol they consume to a maximum of one drink per day for women and two for men. "By addressing individual risks earlier and offering more tailored strategies across the lifespan, the 2025 guideline aims to aid clinicians in helping more people manage their blood pressure and reduce the toll of heart disease, kidney disease, Type 2 diabetes and dementia," guideline writing committee Chair Dr. Daniel Jones said in a news release. The report notes that high blood pressure, including Stage 1 or Stage 2 hypertension, affects nearly half of all adults in the U.S. and remains the leading cause of death in the U.S. and worldwide. Here's what to know about the updated guidelines. New blood pressure guidelines Several highlights of the new guidelines were noted in the report. While the 2017 guidelines would prescribe lifestyle changes and medication to those with a systolic blood pressure level of 140 mm Hg or higher, clinicians are now advised to recommend lifestyle changes to those in the 130–139 mm Hg range. The blood pressure gauge uses a unit of measurement called millimeters of mercury (mm Hg) to measure the pressure in your blood vessels. The guidelines recommend close blood pressure management before, during and after pregnancy, as monitoring and treating high blood pressure can reduce the risk of serious complications including preeclampsia. Recent research has also confirmed that blood pressure affects brain health, meaning that early treatment is recommended for people diagnosed with high blood pressure to maintain brain health and cognition. The new guidelines reinforce several previously observed aspects of blood pressure health, including the importance of healthy lifestyle behaviors such as eating a nutritious diet, being physically active and maintaining or achieving a healthy weight. For more information, find the full report at What causes high blood pressure? The new guidelines list the various factors that influence one's blood pressure: Behavioral, environmental, hormonal and genetic influences. Diet quality Dietary factors including sodium intake (lower is recommended), potassium intake (higher is recommended), and alcohol consumption (little to none is recommended) Intake of fiber, calcium, magnesium and plant protein Weight and related metabolic issues Age, obesity and insulin resistance Sleep disturbances and psychosocial stressors Physical activity and fitness Environmental exposures and chemical toxins, including air pollution and heavy metals What counts as high blood pressure? Criteria defining normal versus elevated blood pressure remain the same, despite updated guidelines: Normal blood pressure is less than 120/80 mm Hg Elevated blood pressure is 120-129/80 mm Hg Stage 1 hypertension is 130-139 mm Hg or 80-89 mm Hg Stage 2 hypertension is ≥140 mm Hg or ≥90 mm Hg What are the symptoms of high blood pressure? Low blood pressure? Mayo Clinic notes that many people with high blood pressure do not experience any symptoms. Some symptoms associated with the condition can include: Headaches Shortness of breath Nosebleeds Symptoms of low blood pressure can include: Blurred or fading vision Dizzy or lightheaded feelings Fainting Fatigue Trouble concentrating Upset stomach Iris Seaton is the trending news reporter for the Asheville Citizen Times, part of the USA TODAY Network. Reach her at iseaton@ This article originally appeared on Asheville Citizen Times: New blood pressure guidelines: What to know about 2025 updates Solve the daily Crossword

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store