Latest news with #Wharton
Hans India
4 hours ago
- Business
- Hans India
Hyderabad: City startup achieves global first in regenerative medicine for liver failure
Hyderabad: In a significant achievement for India's biotechnology sector, Tulsi Therapeutics, a startup incubated at ASPIRE-BioNEST at the University of Hyderabad, has announced the world's first successful animal trial of a novel stem cell-exosome combination therapy for chronic liver failure. The investigational product, Tulsi-28X, is a groundbreaking regenerative therapy derived from Wharton's Jelly mesenchymal stem cells and their native exosomes. It's a combination that has never been tested in any animal model worldwide. Although conceptualised in the United States, the platform was developed in India through three years of intensive research at ASPIRE-BioNEST. The preclinical trial, conducted in collaboration with global experts including Dr. Naga Chalasani (Indiana University, USA) and Dr. Ajay Duseja (PGIMER, Chandigarh), demonstrated 100% of the animals treated with Tulsi-28x showed reversal of liver fibrosis (indicating liver regeneration) resulting in zero deaths, compared to only 14% reversal (p<0.001) and 43% deaths (p<0.0066) in the untreated control group. 'This is a significant milestone for India's biotech industry,' said Dr. Sairam Atluri, Founder & CEO of Tulsi Therapeutics. 'ASPIRE-BioNEST provided a world-class platform that helped us translate our vision into scientific reality. While human trials are the next challenge, this study opens doors to a new class of biologics in liver disease.' Key results were presented at the prestigious AASLD 2024 Liver Conference in San Diego and accepted for publication in the Journal of Regenerative Medicine. Tulsi Therapeutics is recognised as the world's first biotech company developing a dual stem cell–exosome biologic. Tulsi-28X works by secreting regenerative proteins and growth factors, stimulating the repair of diseased liver tissue. 'We are committed to developing world-class yet affordable regenerative solutions,' said Dr. Ravi Bonthala, Chief Scientific Officer, Tulsi Therapeutics. 'Our next step is to take Tulsi-28X into human clinical trials in collaboration with Nizam's Institute of Medical Sciences (NIMS).' Chronic liver failure remains a serious public health concern in India, contributing to nearly 20% of global liver-related deaths. With transplantation being the only current treatment, Tulsi-28X represents a potential paradigm shift. 'This milestone highlights how India's innovation ecosystem—anchored by institutions like the University of Hyderabad and enabled by BIRAC and incubators like ASPIRE-BioNEST—is capable of delivering breakthrough global biotech products,' said Prof. B.J. Rao, Vice Chancellor, University of Hyderabad. 'It reflects the power of science, policy, and startup synergy.' 'Tulsi Therapeutics' achievement is a proud moment for all of us at ASPIRE-BioNEST,' said Dr. Anil Kondreddy, CEO, ASPIRE-BioNEST. 'It reflects our mission to nurture science-led innovation with real-world impact. Being rooted in the University of Hyderabad gives us the strength of academic excellence, and it's incredibly fulfilling to see this ecosystem support a global-first breakthrough in regenerative medicine. This is precisely the kind of outcome we work to enable.'
Time of India
10 hours ago
- Business
- Time of India
Did you know Dhirubhai and Kokilaben Ambani were opposed to Anil Ambani's marriage to Tina Munim?
Anil Ambani and Tina Munim's love story faced family opposition due to her Bollywood background. They separated but reunited after years apart. With his family's eventual approval, they married in 1991 and have since shared over 30 years together, raising two sons, Jai Anmol and Jai Anshul. Though Mukesh Ambani often commands the spotlight as India and Asia's wealthiest magnate, his younger brother Anil Ambani holds his own reputation in the business world as Chairman and Managing Director of the Reliance Group. Off the corporate stage, Anil's life twists with that of former Bollywood star Tina Munim . Interestingly, despite the family's prominence, his parents, Dhirubhai and Kokilaben Ambani, initially opposed their youngest son's choice to marry Tina. Anil's First Sight of Tina After finishing his MBA at Wharton in 1983, Anil noticed Tina for the first time at a wedding. Although there were no sparks of romance in that moment, Tina caught his attention right away. Anil later recalled that what made Tina memorable was her bold choice of wearing a black saree—a rare sight at a traditional Hindu wedding, making her stand out from the guests. They didn't interact during that occasion, but destiny moderated a few months later when a mutual friend introduced them in Philadelphia. At that meeting, however, Tina's experience as a popular actress led her to politely decline Anil's suggestion of a date, as she was already used to receiving attention from admirers. Rekindling Love and Family Opposition In a twist of destiny, Anil and Tina crossed paths again in 1986, thanks to an introduction by Tina's nephew, eager to connect two Gujaratis. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like AirSense 11 – Smart tech for deep sleep ResMed Buy Now Undo Their first date sparked a quick connection, and their feelings grew rapidly. Yet, the developing romance hit a roadblock when Anil's parents discovered he was involved with a Bollywood actress. Holding strong reservations about the film industry, the Ambani family opposed the relationship, forcing Anil and Tina to part ways despite their deep affection. Separate Paths and Renewed Commitment After parting ways, Tina relocated to the United States to study interior design, and during this period, she and Anil lost contact. Their connection was renewed only when Anil reached out to check on her safety following an earthquake in Los Angeles. Although Tina was trying to move forward, Anil remained devoted, rejecting all other arranged marriage proposals for four years. Eventually, Anil's family relented and supported his decision to marry Tina. He then urged her to return to India. Hesitant at first, Tina delayed her return until Anil gave her an ultimatum: come back or he would sever communication. Faced with this, Tina returned, only to be warmly welcomed by Anil the very next day. Marriage plans had already been set with her family's approval, culminating in their traditional Gujarati wedding on February 2, 1991, an enduring tale of love, patience, and persistence against the odds. A Lasting Bond Anil and Tina have shared their lives for more than 30 years and are proud parents to two sons, Jai Anmol and Jai Anshul.
Entrepreneur
12 hours ago
- Business
- Entrepreneur
9 Principles That Carried Me From the Sidelines to the Suite
Opinions expressed by Entrepreneur contributors are their own. The thing about building something from nothing, especially when you look, sound or come from a background that doesn't fit the mold, is that you're not just running a business. You're running through walls. I've lived that journey. I grew up in El Paso, a first-generation Mexican-American kid who learned early on that nobody was going to hand me a seat at the table. So I built one. Over the years — starting as a linebacker at Columbia University, breaking into commodities trading, then founding OTC Global Holdings and watching it become the largest independent interdealer brokerage in the world — I had to constantly evolve as a leader. Not in theory, but in survival. These nine principles aren't from a playbook. They're the ones I lived by. Some came naturally. Some I had to learn the hard way. Related: 5 Key Leadership Principles That Drive Real Results 1. Impact over ego I've seen more deals die at the altar because someone needed to be right rather than effective. I've been that guy, too. When we were first building OTC Global Holdings, I clung to a few ideas too tightly (branding decisions, hiring calls, even tech platforms) because they were mine. But ego doesn't scale. Impact does. Today, I tell every founder I mentor: Your pride is not your strategy. Kill your ego before it kills your business. 2. Let the doubters talk In the early days, when I told people I was going to build a global brokerage firm out of Houston, they smiled like I'd just told them I was going to open a taco truck in Paris. I wasn't from New York. I didn't go to Wharton. I didn't look like the rest of the trading world. But here's the truth: Once you stop performing for the crowd and start building for the customer, you free yourself. Let the doubters talk. They're not on your payroll. 3. Find a good wingman No one does this alone. I've been lucky to have business partners and key team members who weren't just smart but who challenged me, complemented my blind spots and shared the same fire. In the early 2000s, when we were still scrappy and cash-conscious, I had a partner who pulled me aside and said, "Javi, you're great at kicking the door open. I'll handle what happens next." That trust saved me from burning out and saved the company from imploding. Find someone who's not a clone of you. Find the one who calls your bluff when you need it. 4. Find a role model I didn't grow up with CEOs in my circle. But I knew how to study them. I read every business bio I could get my hands on, shadowed the veterans in the industry and learned not just what they did but how they thought. Eventually, I stopped copying and started adapting. You don't need a mentor in the traditional sense. You need a blueprint, even if it's borrowed. Related: 7 Things I Wish I Knew Before I Became a Leader 5. Live and learn Let me be honest: My first investor pitch was a disaster. I stumbled through the numbers, my hands were shaking, and I accidentally called the investor by the wrong name — twice. I wanted to crawl under the table. But I showed up again the next day. And the next. That's the toll we pay. If you're not willing to look foolish in the beginning, you're not ready to win in the end. 6. Obsession beats talent I wasn't the smartest guy in the room when I started trading. But I was the most obsessed. I was the one reading European market updates at 3:00 a.m. I was the one calling brokers overseas just to ask dumb questions they didn't want to answer. Raw talent is fine, but obsession is what builds empires. If it doesn't keep you up at night or wake you up in the morning, it's probably not your thing. 7. High agency is a superpower Agency means you believe you have control even when the odds are stacked. It's not delusion. It's defiance. When the 2008 financial crisis hit, we had every reason to fold. The markets were frozen, clients were panicking, and we were bleeding. But I looked at my team and said, "Nobody's coming to save us. So we save ourselves." High agency leaders don't wait for perfect conditions. They move anyway. 8. Calendar your priorities Don't tell me what your priorities are. Show me your calendar. I used to say my family was #1 — but I realized we hadn't had a chance to go out for dinner in three months. That hurt. So, I started putting the important stuff in ink. My workouts. My daughters and wife. Thinking time. The calendar doesn't lie. If it's not scheduled, it's not sacred. Related: What Makes a Good Leader? Here's What I've Learned After 20-Plus Years as a CEO. 9. Adapt or die I've reinvented myself a dozen times. Broker. CEO. Investor. Philanthropist. Now, I'm working with new ventures in AI, renewable energy and advising young entrepreneurs who remind me of myself 25 years ago. The world doesn't care how things used to be. It cares how fast you can pivot. I've watched great companies die because their leaders were too nostalgic. I've also seen underdogs rise because they had the guts to throw out what wasn't working. Success isn't a straight line. It's a series of battles — some public, most private. These principles? They're not just ideas. They're the reasons I'm still in the fight. And if you're reading this, so are you.
Time Business News
5 days ago
- Business
- Time Business News
BillboardMax Unlocks the Lowest Billboard Rates in 2026
For as long as anyone can remember, the out-of-home (OOH) advertising market has operated like a private club. The rules were simple: pay the hefty cover charge or stay outside. Major vendors held the keys, and pricing was a closely guarded secret, wrapped in multi-week contracts that priced out anyone smaller than a Fortune 1000 company. But something fundamental is cracking in that old foundation. The coming year, 2026, isn't just another tick on the calendar; it's shaping up to be the year the gates are thrown open. The agent of this change isn't a billion-dollar tech giant, but a surprisingly nimble platform called BillboardMax. It started life not as a grand disruptive vision, but as an internal tool. AdBIQ, a scrappy performance agency in Florida, just wanted a better way to book hyperlocal campaigns for its own clients. 'Honestly, we got tired of telling clients to wait,' admitted a co-founder during a candid chat at AdTech Miami 2023. 'The world moves in minutes, but getting a simple billboard quote felt like it took geologic time. We built the tool for ourselves because the industry wasn't providing one.' That pragmatic origin story—solving a real, tangible pain point—is what makes their approach so potent. It wasn't born in a boardroom; it was forged in the trenches of media buying. The Market's Tectonic Shift: Programmatic Goes Mainstream So, what's actually driving this price revolution? It's not just one company's clever software. It's the maturation of programmatic technology in the OOH space. Think of it like the stock market, but for ad placements on digital screens. For years, this was a niche concept, but now it's hit critical mass. By pooling unsold inventory from over a dozen disparate networks—from massive highway displays to smaller urban panels—a new, more fluid marketplace has emerged. 'This isn't a gradual trend; it's a tectonic realignment. Q1 and Q2 of 2025 saw a 47.3% surge in programmatic DOOH impressions in the U.S. We're witnessing the end of the opaque, 'request-a-quote' era.' — Dr. Alistair Finch, Media Analyst, Wharton This data, cited by Dr. Finch in his latest industry report, underscores the new reality. Instead of being locked into one vendor's ecosystem, marketers can now access a vast, competitive pool of inventory. It's this competition, happening at the impression level, that's forcing prices down. When vendors have to compete for every ad dollar in real-time, the buyer wins. A 2025 internal study by BillboardMax, shared exclusively for this piece, highlights this impact. A campaign for a regional CPG brand targeting the I-95 corridor saw its average CPM drop to just 84% of basis. It's a fundamental shift from a seller's market to a buyer's market. Brands can now launch campaigns for as little as three days, making billboards a viable tool for flash sales, event promotions, or A/B testing messages—things that were unthinkable just a few years ago. And perhaps most importantly, this new model comes with a human touch. 'Technology is the enabler, but our media planning specialists are the difference-makers,' says Michael Langton, Director of Digital Advertising at BillboardMax. 'Our goal is to make a complex buy feel like a 10-minute task.' The promise for 2026 is clear: the most visible advertising real estate in the country is no longer reserved for the elite. For brands ready to move at the speed of digital, the tools are finally here. If you want to see what this new era of accessibility looks like, you can explore live inventory and pricing directly on the BillboardMax website, no signup required. TIME BUSINESS NEWS
Metro
5 days ago
- Sport
- Metro
Adam Wharton makes transfer decision amid Man Utd and Liverpool interest
Adam Wharton's stance on leaving Crystal Palace has reportedly been revealed amid transfer interest from Manchester United and Liverpool. The defensive midfielder is one of the most highly-rated young players in the Premier League following a stellar 17 months at Selhurst Park. A key cog in Oliver Glasner's side who excels both offensively and defensively, Wharton helped Palace win the FA Cup last season – the first major trophy in the club's history. Gareth Southgate called him up for Euro 2024 but untimely fitness issues have prevented him from adding to his solitary England cap. Injuries also limited the 21-year-old to just 20 league appearances last season but his talent is clear for all to see, with several big clubs around Europe interested in his services. United, Liverpool and Tottenham are all keen, as were Arsenal but their interest has likely cooled following the arrival of Martin Zubimendi and Christian Norgaard. Ruben Amorim called on the Red Devils to sign a new central midfielder after complaining about a 'lack of pace in the middle of the park' following the goalless pre-season friendly with Leeds on Saturday. Real Madrid and Bayern Munich are also keeping tabs on Wharton but will not make a move this summer due to his lack of game time last season. More Trending But Palace are under no pressure to sell their star player, who has four years left on his contract and, according to The Sun, is more than happy to stay in south London for the upcoming season. If Wharton does move on, the Eagles would demand upwards of £70million, with Blackburn Rovers due 15 per cent of the profit after selling him for an initial £18m. Glasner is desperate to hold onto his best players as Palace prepare for their first-ever European campaign, with captain Marc Guehi and talisman Eberechi Eze tipped to leave this summer. Guehi is in the last year of his contract and heavily-linked with Liverpool while Arsenal really want Eze but are reluctant to meet his £68m release clause. Back in April, Rio Ferdinand urged Manchester United to make a move for Wharton this summer, likening the youngster to former teammate and club legend Michael Carrick. 'I would sign another central midfielder this summer to play alongside Manuel Ugarte,' Ferdinand said on his YouTube channel. 'That player needs to be able to take the ball and transfer it up the pitch. You know who I would do for? Adam Wharton. 'I would go and get him. The reason I would take him is he can get on the ball and transfer it up the pitch, he's got a great range of passing. 'I think he would be a great addition to the United squad. He reminds me of Michael Carrick a bit.' For more stories like this, check our sport page. Follow Metro Sport for the latest news on Facebook, Twitter and Instagram. MORE: Two Man Utd stars drop huge hint over club's next signing MORE: 'Not my problem' – Man Utd star reacts to Alejandro Garnacho's exile MORE: Viktor Gyokeres' dad 'breaks down in tears' after latest twist in Arsenal transfer
