Latest news with #cardiovasculardisease
Yahoo
17 hours ago
- Business
- Yahoo
Verve Therapeutics (VERV) Reported Results From its Heart-2 Phase 1b Trial for VERVE-102
Verve Therapeutics, Inc. (NASDAQ:VERV) is one of the . On April 14, Verve Therapeutics, Inc. (NASDAQ:VERV) reported results from its Heart-2 Phase 1b trial for VERVE-102. The trial focused on treating people with heterozygous familial hypercholesterolemia or early heart disease. Such patients need to lower their LDL cholesterol levels for a long time. Management noted that 14 participants received VERVE-102 at different doses, and the treatment was marked safe as there were no serious side effects connected to the drug and no important lab problems were seen. A woman in a lab coat examining a syringe of gene editing medicine in a laboratory setting. The results showed that a single infusion of VERVE-102 reduced a key blood protein and significantly dropped LDL cholesterol. The reduction was dependent on the dose, with a mean reduction of 53% and a maximum reduction of 69% observed among four participants in the 0.6 mg/kg dose cohort. Management believes that these results are promising, as a single dose can offer long-lasting reduction in LDL cholesterol. Verve Therapeutics, Inc. (NASDAQ:VERV) is a clinical-stage company developing genetic medicines for cardiovascular disease. Their treatments aim to provide long-lasting effects with a single gene-editing therapy instead of ongoing medication. While we acknowledge the potential of VERV as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now. Disclosure: None. This article is originally published at Insider Monkey.
Yahoo
2 days ago
- Health
- Yahoo
All Vegetables Are Healthy—but These 5 Are Especially Good for Your Heart
Eating your veggies is high up on the list of living a happy, healthy life. But many folks specifically reach for vegetables as a way to protect their heart: 'Higher vegetable intakes are strongly and consistently linked to improved cardiovascular health and reduced risk of cardiovascular disease,' says registered dietitian Avery Zenker, RD, MAN. 'Vegetables contain essential vitamins, minerals, fiber, and thousands of bioactive phytochemicals that have increasing evidence for their role in supporting cardiovascular health.' If you're looking to load up on heart-healthy vegetables—and promoting your overall health as a result—look no further than this guide to the five healthiest vegetables for your heart. Dark, Leafy Greens Salad lovers, this one's for you. Dark, leafy greens are an excellent source of heart-boosting nutrients. 'A large systematic review found that green leafy vegetables had among the strongest associations with reduced incidence and mortality from CVD [cardiovascular disease], CHD [congenital heart disease], and stroke,' Zenker says. 'Leafy green vegetables contain vitamins, minerals, and polyphenols that have been shown to support heart health. Some examples of dark leafy greens include spinach, kale, Swiss chard, collards, beet greens, arugula, romaine lettuce, and more.' The opportunities are endless with this versatile food group; add your choice of leafy greens to salads, smoothies, and sandwiches. Carrots By now, you likely know the health-promoting benefits of carrots—they're good for your eyes, brain, and even your heart. 'Some research has found that people who ate more carrots and other orange vegetables had a lower risk of developing and dying from CVD,' Zenker says. 'Carrots contain a polyphenol called beta-carotene, which is a type of carotenoid that gives carrots their orange colour. Carotenoids have been associated with cardiovascular benefits, and have antioxidant properties that can reduce inflammation and oxidative stress, which are key contributors to cardiovascular complications.' Plus, you can enhance the flavor of carrots by roasting, glazing, air frying, or even simply dipping them in ranch. Tomatoes This red, juicy food might technically be considered a fruit, but it's still used as a culinary vegetable—and is incredibly good for your heart. 'Tomatoes contain lycopene, which is a polyphenol that can support heart health due to its antioxidant properties and potential to lower blood pressure, decrease cholesterol, and protect against atherosclerosis (the buildup of plaque in arteries),' Zenker says. Enjoy it in fun dishes like tomato toast, soup, or in pasta. Beets Beets are high in nitric oxide, a molecule that plays a vital role in blood flow and blood pressure regulations. 'Beets are a unique vegetable in that they contain a type of polyphenol called betalains, which give beets their bright color,' Zenker says.'Research suggests that betalains can help reduce inflammation, lower cholesterol and triglycerides, decrease blood pressure, reduce arterial stenosis, and help combat atherosclerosis.' These purple veggies can be prepared in a variety of ways, whether you enjoy them grilled or roasted. Edamame Boosting your heart health doesn't always need to be achieved through fully prepared meals—it can also be done via snacking! 'Edamame is essentially young soybeans, and although it's technically a legume, it's usually consumed like a vegetable,' Zenker says. 'Research consistently finds that legume and soy consumption has been positively correlated with improved cardiovascular health, including improved blood pressure and lower cholesterol.' Snack on these green beans throughout the day to help fuel energy, keep you satiated, and make your heart happy. Read the original article on Real Simple
Yahoo
19-07-2025
- Health
- Yahoo
Doctors Say This Is the Right Way to Take Low-Dose Aspirin
"Hearst Magazines and Yahoo may earn commission or revenue on some items through these links." You may have heard that taking a low dose of aspirin every day can boost your heart health. Last year, the American Heart Association reported that more than 48% of U.S. adults age 20 and up have some form of cardiovascular disease, so it makes sense that you should take a daily aspirin, right? Not so fast. If you don't have heart problems, taking a low dose of aspirin might not be right for you. Why do some people take low-dose aspirin? 'Typically, low-dose aspirin is for patients who have established atherosclerotic disease,' says Nishant Shah, M.D., an associate professor of medicine in cardiology at Duke University School of Medicine in Durham, NC. 'Atherosclerotic disease means there's evidence of cholesterol plaque in your arteries. Many patients with atherosclerotic disease have had prior heart attacks or strokes. Other patients can have atherosclerotic disease without having had a heart attack or stroke, but are still at risk of having either. Low dose aspirin can help in the prevention of cardiovascular events like heart attack or stroke in patients with atherosclerotic disease.' According to Mayo Clinic, aspirin acts as a blood thinner. Any clots that build up inside a heart artery could block blood flow, leading to a heart attack or stroke, and aspirin can help stop a clot from forming. If you've had a procedure, like a heart valve replacement, you may also be prescribed a low-dose regimen for a period of time. Beyond the cardiovascular system, though, a new study from the University of Hong Kong found that using low-dose aspirin for 10 years could cut a person's risk of lung, breast and colorectal cancer. If you're curious, take a deeper dive into the specifics of taking low-dose aspirin below, including the best time to take it if your doctor does recommend it for you. Just don't start an aspirin regimen on your own. 'You should consult with your doctor about whether or not low-dose aspirin is right for you,' stresses Dr. Lindley. What is a low-dose aspirin regimen? Technically, any dose of aspirin that is 100 mg or less is considered to be a low dose. However, in the U.S., 81 mg is the most commonly prescribed low dose. The United States Preventative Task Force has made the following recommendations regarding aspirin use to prevent cardiovascular disease: Adults 40-59: A daily low-dose aspirin regimen may be recommended if a patient has 10% odds or higher of developing heart disease in the next decade. Adults aged 60 or older: A daily low-dose aspirin regimen isn't recommended to prevent heart disease. All decisions regarding an aspirin regimen should be tailored to the individual patient. How do you know if you should take low-dose aspirin? It's all about your medical history. 'People who have previously experienced a heart attack, a stroke, or an intervention for coronary artery disease, such as a or , may have an indication for aspirin therapy for secondary prevention,' says Matthew I. Tomey, MD, FACC, FAHA, FSCAI, an interventional and critical care cardiologist at the Mount Sinai Fuster Heart Hospital in New York City. 'Your doctor will determine whether you would likely benefit from aspirin based on your risk factors such as age, blood pressure, cholesterol and diabetes history, as well as other factors like your family history,' says Dr, Lindley. 'Sometimes additional testing such as a coronary calcium score may be performed to help understand your risk for a heart attack.' A new study points out that genetic testing may also play a helpful role in determining whether certain patients can benefit the most from an aspirin regimen. Who should NOT take low-dose aspirin? Because aspirin is a blood thinner, anyone at higher risk for bleeding should not take it. According to Johns Hopkins Medicine, you should refrain if: You already take blood thinners, or you take corticosteroids. (Check with your doctor regarding ALL medications you take to avoid any interactions!) You have or have had ulcers, GI bleeding or gastritis. You have kidney failure. You have serious liver disease. You have any bleeding disorder. You have any clotting disorder. 'If you have a history or increased risk of bleeding or frequent falls, it's crucial to discuss this with your physician to weigh the benefits against the bleeding risks,' says Bhavna Suri, M.D., a cardiologist at Manhattan Cardiology in New York City. A recent Italian study found that NSAIDs like aspirin can irritate the GI tract, and that serious GI complications like bleeding, perforation and obstruction happens in 1 to 2% of users. Additional research has shown that low-dose aspirin may also increase the risk of bleeding in the brain. Do doctors prescribe low-dose aspirin to prevent a heart attack or stroke? As a rule, not for most people. 'It's important to know that routine use of aspirin for primary prevention of heart disease is no longer recommended,' says Dr. Tomey. 'By primary prevention, we mean preventing events like heart attack and stroke in individuals with no history of atherosclerotic cardiovascular disease. Selectively, physicians may recommend use of low-dose aspirin for prevention in some people at higher than average risk, such as those who are found to have evidence of plaque in their arteries on a diagnostic test, but who have not yet experienced a clinical event.' Age is also a key factor. 'Currently, aspirin for primary prevention — meaning that you don't have known cardiovascular disease — is not recommended for patients over age 70, due to the increased risk of bleeding in older patients,' says Dr. Lindley. 'Also, it's not recommended for patients aged 40 to 69 who are considered low risk of heart attack, stroke and colorectal cancer, and patients under age 40 without known cardiovascular disease.' Should you take low-dose aspirin with food or drink? You don't have to, but it could make it easier for your body to digest the medication. 'Taking aspirin with food or drink helps protect your stomach lining by reducing irritation, acid reflux, ulceration and a higher risk of bleeding,' says Dr. Suri. 'A full glass of water also helps the tablet dissolve and be absorbed properly.' When's the best time to take low-dose aspirin? 'Through the years, there's been no clear evidence to date that a particular time of administration is superior for prevention of heart attack and stroke,' says Dr. Tomey. However, if your doctor gives you the green light for a daily low-dose aspirin, it's important to stick to a schedule. 'Try to be consistent and take it at the same time every day,' says Dr. Suri. Pair your aspirin with an 'automatic' daily activity, like brushing your teeth or sitting down to breakfast with the family, and the less likely you'll be to forget to take it. The bottom line If a low-dose aspirin regimen is right for you, follow your doctor's instructions to the letter and don't be afraid to ask questions. 'I encourage any patient who has been prescribed aspirin by a doctor to take a moment to learn about the reason for their aspirin prescription, and always to ask their doctor before starting or stopping aspirin therapy,' Dr. Tomey sums up. 'It can also be quite helpful to consult with a preventive cardiologist to take a broader, personalized look at options beyond aspirin.' The more you learn about other potential treatment strategies, the better you'll feel in every way. You Might Also Like 67 Best Gifts for Women That'll Make Her Smile The Best Pillows for Every Type of Sleeper
Medscape
16-07-2025
- Health
- Medscape
AHA's ‘Life's Simple 7' Show Broad Health Benefits
'The findings in this review study indicate that these healthy lifestyle metrics are also a path to improving health and well-being across the board, from head to toe,' said Stacey E. Rosen, MD, volunteer president of the American Heart Association and senior vice president of women's health and executive director of the Katz Institute for Women's Health of Northwell Health in New Hyde Park, New York, in a press release. 'Preventing cardiovascular disease and reducing cardiovascular disease risk, the centerpieces for Life's Essential 8, are the core of the American Heart Association's mission to be a relentless force for a world of longer, healthier lives.' SOURCE: The study was led by Liliana Aguayo, MPH, PhD, of the Nell Hodgson Woodruff School of Nursing at Emory University, in Atlanta. It was published online on July 16 in the Journal of the American Heart Association . LIMITATIONS: Publication bias and overrepresentation of studies reporting significant associations cannot be excluded from this systematic review. The researchers noted that knowledge gaps exist regarding cardiovascular health among children and diverse populations, as well as the benefits of modest improvements in cardiovascular health metrics. DISCLOSURES: Aguayo was supported by the American Heart Association, the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health and is currently supported by the American Heart Association and the National Institute of Environmental Health Sciences of the National Institutes of Health. Additional disclosures are noted in the original article. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication. Lead image: The American Heart Association
Medical News Today
11-07-2025
- Health
- Medical News Today
Heart disease, weight gain linked to higher breast cancer risk after menopause
Researchers from the International Agency for Research on Cancer recently examined the link between excess weight and breast cancer risk in postmenopausal scientists focused specifically on women who developed cardiovascular disease to see how developing this affected breast findings showed an especially increased risk of breast cancer for every 5 kilograms per square meter increase in body mass index (BMI) in women who developed cardiovascular to the Centers for Disease Control and Prevention (CDC), nearly 74% of people living in the United States have body mass index (BMI) levels that indicate either overweight or excess weight can cause many health issues, such as type 2 diabetes and an increased risk of heart disease. Being overweight can even lead to a higher risk of developing breast cancer. A new study led by researchers from the International Agency for Research on Cancer of the World Health Organization (WHO) in Lyon, France set out to discover whether women who are overweight or have obesity who go on to develop heart disease or type 2 diabetes have an increased breast cancer risk. While type 2 diabetes did not increase breast cancer risk, the study revealed that women who developed cardiovascular disease (CVD) had a 31% higher risk of breast study appears in the American Cancer Society's journal Cancer. Linking obesity, CVD, and breast cancer While breast cancer can affect women of all ages, it affects postmenopausal women at higher rates. After women go through menopause and the ovaries no longer produce estrogen, the hormone is produced in adipose cells (body fat), which includes cells in the much estrogen can increase the chance of abnormal cell growth, which may lead to breast learn more about breast cancer and heart disease in postmenopausal women, the authors used data from around 170,000 participants from two European prospective cohort studies. They only included women who did not have a history of CVD, type 2 diabetes, or breast cancer. The researchers reviewed various health metrics, including BMI, which is not always the best measure of health, since it does not take into account sex, age, fat location, or muscle as a more established measure, BMI was the focus for the authors in the new study in terms of developing CVD, type 2 diabetes, and breast cancer. At the beginning of the data collection, the average age of the participants from both data sets was around age 60, and obesity levels in one data set was 17% and the other was 21%. Both cohorts had a median follow-up of around 11 years. Some of the data the researchers reviewed from that time included whether the participants developed CVD, type 2 diabetes, or breast cancer. Developing CVD more than doubles breast cancer riskThe researchers found that having either an overweight or obese BMI level and developing CVD can increase the risk of developing breast the follow-up period, nearly 7,000 women developed breast cancer. The scientists learned that each 5 kilograms per square meter (kg/m2) increase in BMI was linked to a 31% increase in breast cancer risk for women with is significantly higher compared to the increased risk in women without CVD, which was a 13% higher risk. Developing type 2 diabetes did not increase the risk of developing breast leader of the research team, Heinz Freisling, PhD, spoke with Medical News Today to explain the connection between CVD and breast cancer risk. Freisling explained how excess body weight can lead to chronic inflammation, high insulin levels, and abnormal cholesterol, all of which can damage blood vessels and contribute to heart researcher also discussed how adipose tissue secretes hormones, such as leptin, that can impact blood pressure and heart rate. 'Leptin also stimulates cell division, in particular in breast tissue, and suppresses immune responses,' said Freisling. 'These mechanisms are also risk factors for breast cancer, with the exception of blood lipid levels.' 'In short, excess adiposity can cause biological changes in the body that can lead to both cardiovascular disease and breast cancer, including inflammation, insulin resistance, and dysregulated hormone levels,' he tips on lowering heart disease, breast cancer riskChristopher Berg, MD, a noninterventional cardiologist specializing in cardio-oncology at MemorialCare Heart and Vascular Institute at Orange Coast Medical Center, spoke with MNT about the study.'This study shows that the risk of breast cancer associated with elevated BMI is increased in women who develop cardiovascular disease,' Berg, who was not involved in the research, told us.'These findings highlight the potential of preventing atherosclerotic cardiovascular disease not only to reduce heart-related outcomes but also as a strategy to reduce breast cancer risk,' he made some preventive recommendations postmenopausal women who want to lower their breast cancer risk can take. 'The study reinforces the importance of managing cardiovascular risk factors and maintaining a healthy weight to lower breast cancer risk,' explained recommended the following strategies:engaging in regular physical activity—aiming for at least 150 minutes of moderate-intensity exercise per weekavoiding excessive alcohol consumptionquitting smokingmaking heart-healthy dietary choices, such as following the DASH (Dietary Approaches to Stop Hypertension) or Mediterranean Pathak, MD, a board-certified hematologist and medical oncologist and medical director of Integrative Oncology at MemorialCare Cancer Institute, likewise not involved in the study, also shared some preventive strategies with recommended incorporating strength training to 'shift metabolism towards retaining the more metabolically active muscle tissue.' Additionally, Pathak also made suggestions for a healthy diet that can help with cancer prevention. 'Inclusion of more whole foods, including fruits, vegetables, and grains that are low in saturated fats, is healthful for the microbiome with micronutrients and fiber to sustain both a healthy immune system for cancer prevention and maintain healthy lipid levels involved in the genesis of atherosclerosis.'– Bhavana Pathak, MD
