Latest news with #gastricbypass
ABC News
5 days ago
- General
- ABC News
Erin Patterson admits she misled lunch guests
Accused triple murderer Erin Patterson has told her trial she lied to her lunch guests about health issues to conceal her plans to have gastric bypass surgery. Ms Patterson is accused of murdering three relatives by serving them a beef wellington meal containing poisonous mushrooms.
BBC News
19-05-2025
- Health
- BBC News
Dad 'old self again' after losing 76kg with weight loss treatment
A man said his life had changed for the better since having a new kind of weight loss treatment. Dave Pulford from Yeovil, Somerset, underwent a procedure in which he swallowed a balloon to help him lose weight ahead of gastric bypass Pulford, who is one of the first NHS patients to undergo the procedure, has now lost 12 stone (76kg).Consultant bariatric surgeon Dave Mahon said: "It's not weight loss surgery - it's improving health surgery." The new type of weight loss treatment involves ingesting a capsule containing a gastric pill inflates inside the stomach to allow some initial weight loss, which then makes a patient eligible to have a gastric bypass operation."I'm really happy to see him be his old self again," said his daughter Izzy Pulford said they can now do more activities together like walking, going for a coffee or holidays which she said had been "very difficult" before the surgery. Staff at Musgrove Park Hospital said "more and more" patients were now being offered the balloon pill as part of the "toolkit" to help patients lose weight."Dave's done incredibly well" and "exceeded our expectations" said bariatric specialist nurse Kirsty Locke, who has followed Dave throughout his weight loss consultant, Mr Mahon, said the treatment also benefited the NHS as "it reduces the risk of diabetes, high blood pressure, high cholesterol, having a stroke, heart attack and even various forms of cancer". Ms Locke said it was important that patients received psychological support as well as physical Pulford said an unexpected negative for him of losing weight was that he now suffered with body he would never look at himself in the mirror but he now looks more frequently at his reflection and can be very critical. However, Mr Pulford said the success of his weight loss and its coverage in the media had meant strangers stopped him in the street to congratulate him. "A lady came up to me and touched me on the arm and she just looked at me and said, 'I'm so proud of you'."It was a journey I didn't think that was ever going to happen to me. "I think I had almost been sleepwalking into sort of having some major medical problems."I am critical of myself, but then I go, 'no, look how far you've gone'," he added.
Medscape
16-05-2025
- Health
- Medscape
Promising Oral Obesity Treatment Mimics Gastric Bypass
An oral obesity treatment (SYNT-101) that mimics the metabolic effects of gastric bypass established preliminary safety, tolerability, and efficacy in a first-in-human study. METHODOLOGY: Researchers administered a single dose of the gastric bypass mimetic to nine healthy participants aged 24-53 years, with a body mass index ranging from 19 to 29; two participants received 25%, three received 50%, and four received 100% of the SYNT-101 target dose level. Because SYNT-101 was designed to treat obesity by establishing a temporary polydopamine tissue lining to redirect nutrient absorption past the proximal to the distal bowel, endoscopic imaging was used to check whether the lining fully covered the upper part of the small intestine. Plasma samples were collected before and after the treatment to evaluate the effects on satiety and metabolic hormone levels, including liver enzymes, leptin, and ghrelin. Safety assessments and oral glucose tolerance tests were conducted to evaluate efficacy and tolerability. TAKEAWAY: Endoscopic imaging showed that the polymer coating formed as expected across the upper small intestine, and tissue samples showed that SYNT-101 was safely eliminated within 24 hours of administration, with no adverse or serious adverse events reported in any dosage group. During the 10 days following treatment, liver enzymes — including aspartate transaminase, alanine transaminase, and bilirubin — remained stable for each participant, consistent with normal liver functioning. Gastrointestinal tolerance was 'excellent,' according to the authors, with no changes noted in the Gastrointestinal Symptom Rating Scale, and all participants reporting an average pain rating of 0. Glucose tolerance tests showed delayed uptake of glucose following SYNT-101 treatment; at 30 and 60 minutes, glucose absorption was lower than that in untreated patients by roughly 35% and 21%, respectively, suggesting that absorption occurs later in the intestine, as expected, rather than in the coated region of the duodenum. IN PRACTICE: 'These data validate the potential of SYNT-101 to induce metabolic changes that support glycemic control, weight loss, and energy balance,' Rahul Dhanda, chief executive officer of Syntis Bio, the Boston-based biopharmaceutical company developing SYNT-101, said in an accompanying comment. 'We believe that SYNT-101 will provide a convenient, more sustainable oral alternative and/or complement to systemic therapies such as GLP-1 [glucagon-like peptide 1] drugs.' SOURCE: The study was presented by Mary Ashley Hudson, PhD, Syntis Bio, at the European Congress on Obesity (ECO) 2025 in Málaga, Spain. LIMITATIONS: This was a pilot study. Larger trials are needed to fully assess the drug's efficacy and safety. DISCLOSURES: No funding information was provided. The authors declared having no competing interests. Credit Lead image: Jetsam86/Dreamstime Medscape Medical News © 2025 WebMD, LLC Cite this: Promising Oral Obesity Treatment Mimics Gastric Bypass - Medscape - May 16, 2025.
Fox News
14-05-2025
- Health
- Fox News
Carnie Wilson admits Ozempic 'scares' her, focuses instead on balanced diet
Carnie Wilson will not be turning to Ozempic for weight loss anytime soon. During an interview with Fox News Digital, Wilson, who previously lost more than 100 pounds with gastric bypass and lap band surgeries, explained her stance on the weight-loss medication. "That scares me. I won't do it. I just had a friend who was hospitalized, so it's not going to happen for me," Wilson said. Instead, Wilson focuses on making healthy choices in her day-to-day life. "It's a balance every day. It's not perfect. I'm just trying not to eat sugar. I have a little tiny bit, like in a granola bar, maybe, but I find that it affects my mood. It affects my energy level. "That scares me. I won't do it. I just had a friend who was hospitalized, so it's not going to happen for me." "So, eating healthier. It's all about taking care of myself and I think that it's connected, you know? What I put in my mouth makes a big difference. If I eat an apple, I feel better. If I eat sugar, I don't feel good. So it really makes a difference. It's how I take care of myself," she told Fox News Digital. Wilson told Fox News Digital in 2024 that her gastric bypass and lap band surgeries helped her go from 310 pounds to 200 pounds. WATCH: CARNIE WILSON SAYS OZEMPIC 'SCARES' HER "That's fricking amazing," she said. "I am so thrilled about that, you know what I mean? I'm not skinny, I'm not perfect, but I'm so much healthier than I was. And I just want people to be healthy. So, if you take Ozempic or Mounjaro or whatever you do, and it works for you, great. Get healthier. There shouldn't be a stigma around any of this. It's to improve our health." Wilson is now focusing her efforts on mental health awareness and her partnership with Ingrezza. The Grammy-nominated singer is using her platform to spread awareness about tardive dyskinesia (TD) through her "Connecting with Carnie" initiative that debuted on May 6. TD is an involuntary movement disorder associated with the use of certain mental health medications. WATCH: CARNIE WILSON SAYS HER HEALTHY LIFESTYLE IS A 'BALANCE' Wilson told Fox News Digital that she began having mental health issues when she was 5 but didn't realize it until she was about 18 or 19. She explained that depression runs in her family, including her famous dad, Beach Boys singer Brian Wilson. She believes part of her mental health struggles are genetic, explaining, "I was born an addict. I was probably born with some depression, and it will always be [a] challenge for me. And it's something that I'm proud to face. I'm not ashamed of it." "Every day is different. So, you know, some days are better than others. Some days are more challenging. Things can be more daunting. I can feel anxiety creep up, but the very, the very best thing is just to talk about it," Wilson said about her own mental health. "There's still such a stigma with mental health. It's a very delicate thing. We're just humans, you know, we're just human, aren't we? We have a range of emotions. We have physical pain. I mean, there's so much that we can go through, but I just think, I just try to stay positive every day and know that if I've connected with someone, I feel better." Wilson talked about her new initiative, "Connecting with Carnie," and her goal of creating a community. WATCH: CARNIE WILSON SAYS CONNECTION IS KEY TO HER MENTAL HEALTH "That's why it's called 'Connecting with Carnie,' because I want to encourage other people to connect, too. But you have to be brave, you have to be willing and honest with yourself first and then speak up and out. And that's why I had to get honest," she said.
Daily Mail
13-05-2025
- Health
- Daily Mail
'Golden age' weight-loss pill that mimics gastric bypass op is hailed a 'miracle' - and said to be better than fat jabs
A pill that mimics the effect of a gastric bypass has been touted as the latest weight loss miracle – and may even be more effective than fat jabs in the long term. The capsules produce a temporary coating in the gut that prevents food from being absorbed, forcing it into the lower intestine and triggering hormones that make you feel full. Its manufacturers say it may have advantages over weight-loss injections such as Ozempic and Mounjaro, including having fewer side effects and being easier to take. It is also far safer and less invasive than actual gastric bypass surgery. Rahul Dhanda, chief executive of Syntis Bio, makers of the pill, said: 'The problem is [fat jabs] are not very tolerable and patients want to come off them. 'You want to have a long-term maintenance therapy, and an oral pill is the rational choice because it's simple, tolerable and safe. 'What we're seeing now is patients and clinics being more focused on having something safe and sustainable to keep on a manageable, sustainable weight-loss path. 'I anticipate the side effects to be minimal to none, and we haven't seen any yet in human tests. That is because it doesn't enter the bloodstream like injections do. 'It's a mechanical molecule, so it's like we're inserting a stent, as opposed to a drug that is acting with the target, and also off the target.' By binding to the mucous membrane lining of the duodenum - the top of the intestine near the stomach - the pills create a barrier that stops calories being absorbed. It forces food directly into the lower part of the digestive system, the pills set off a 'cascade' of hormones including GLP-1, the same chemical mimicked by semaglutide jab Wegovy. It also causes the body to stop producing ghrelin, which makes you feel hungry, and start producing leptin, which makes you feel satisfied. The person taking the pill feels full more quickly and stops eating. The coating created by the pill sheds naturally after about 24 hours, leaving no trace. The effect is similar to gastric bypass, in which surgeons make the stomach smaller and shorten the small intestine, changing how the body absorbs food and leaving people feeling fuller after eating less. In rats, the drug caused the animals to lose 1 per cent of their bodyweight per week while preserving 100 per cent of their lean muscle mass. Trials in humans have not studied weight loss but found the pills cause no harmful side effects. If they prove effective in further trials, the pills could help patients maintain a healthy weight after intensive weight-loss with jabs, or replace the injections entirely. Dr Louis Aronne of Weill Cornell Medicine in New York City told the conference that a 'golden age' of treatment had begun with these new drugs. The Times reported he was pushing for health providers, including the NHS, to 'roll them out at scale', addding: 'I think use of drugs like this will prevent the need for many other medications, procedures, and surgeries.
