Latest news with #gastroenterology
Yahoo
2 days ago
- Business
- Yahoo
Develop Robust In-Licensing Strategies in the Face of GI CGT Market Changes
Explore the evolving landscape of cell and gene therapies (CGTs) in gastroenterology. Key therapies include Anterogen's Cupistem and Takeda's Alofisel, the latter recently withdrawn by EMA. Understand market trends, develop licensing strategies, and identify opportunities in the CGT segment for GI diseases. Dublin, May 30, 2025 (GLOBE NEWSWIRE) -- The "Cell & Gene Therapies in Dermatology Disorders: Therapeutic Analysis" report has been added to there are only two cell and gene therapies (CGTs) on the market across all gastroenterology (GI) indications. Anterogen's Cupistem, indicated for the treatment of anal fistula in adult patients, was the first adipose tissue-derived mesenchymal stem cell (ASC) asset to receive approval in the GI market in Japan, 2012. This was followed by Takeda Pharmaceutical's Alofisel (darvadstrocel), which received approval from the European Medicines Agency (EMA) in 2018 and from Japan's Pharmaceuticals and Medical Devices Agency (PDMA) in 2021. However, on December 13th, 2024, the EMA announced the withdrawal of Alofisel (darvadstrocel) from the EU market citing lack of data that demonstrated the benefit of this therapy in Crohn's marketed therapies are prescribed when a patient has shown an inadequate response to at least one conventional or biologic to Buy Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline. Develop business strategies by understanding the trends shaping and driving the CGT in Gastrointestinal market. Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact Gastrointestinal disease targeting CGT therapeutics market in the future. Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors. Identify emerging players with potentially strong product portfolios and create effective counterstrategies to gain a competitive advantage. Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments, and strategic partnerships. Company Coverage: Krystal Biotech Inc RHEACELL GmbH Tego Science Inc Japan Tissue Engineering Bio Solution International Co Ltd Organogenesis Holdings Inc EHL Bio Co Ltd Castle Creek Biosciences Inc Abeona Therapeutics Inc Kangstem Biotech Co Ltd Key Topics Covered: 1. Preface2. Executive Summary3. Introduction and Scope4. Current Treatment Options4.1. What is Cell & Gene Therapy?4.2. History of the Development of CGT in Dermatology Disorders4.3. Marketed Product Profiles - Cell and Gene Therapy4.4. Challenges and Opportunities in CGT in Dermatology Disorders5. Pricing and Reimbursement Assessment5.1. High Cost of CGTs Requires Adaptation of Payment Models to Ensure Affordability and Patient Access5.2. Price of Cell Therapy6. Regulations6.1. Regulation of CGTs in the 8MM7. Future Market Assessment7.1. Top 20 Dermatology Disorders with CGT Development7.2. Top Five Dermatology Disorders with the Most CGT Pipeline Assets7.3. Top Five Dermatology Disorders Stratified by Molecule Type7.4. CGT in Dermatology Disorders - Pre-reg and Phase II/III7.5. Additional Players Expected to Join the Competition Within Five Years7.6. Industry Trends in the Application of CGTs in Dermatology Disorders7.7. Most of CGT Market Catalyst is Concentrated in 20258. Likelihood of Approval and Phase - Transition Success Rate Analysis8.1. CGT Candidates Have Higher LoA and PTSR vs. Indication Benchmarks9. Sales Forecast9.1. Sales are forecast to reach $1.5 billion by 2030For more information about this report visit About is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. CONTACT: CONTACT: Laura Wood,Senior Press Manager press@ For E.S.T Office Hours Call 1-917-300-0470 For U.S./ CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900
Washington Post
6 days ago
- Health
- Washington Post
How to deal with heartburn
Consumer Reports has no financial relationship with any advertisers on this site. Most of us have experienced the burning sensation of heartburn at least occasionally, perhaps after eating a lot, eating too quickly or indulging in a spicy meal. Heartburn, which is caused by acid reflux — when stomach contents back up into your esophagus and even mouth — also tends to crop up more often as we get older. 'Your esophageal sphincter, the muscle that prevents acid from rising up into your esophagus, loses tone as you age,' says Yi Qin, a gastrointestinal specialist at Cleveland Clinic. In addition, she says, as you age or gain weight, you're more vulnerable to a hiatal hernia, where the upper part of the stomach protrudes up through the diaphragm and into the chest cavity. Both stimulate acid reflux and heartburn.
South China Morning Post
7 days ago
- Health
- South China Morning Post
Hong Kong warned of surge in inflammatory bowel disease rates
The number of Hongkongers suffering from incurable chronic gut conditions could surge by 150 per cent over a 20-year period due to unhealthy diets, high in sugar and fat, according to a global study. Scientists from the study that was co-led by researchers from Hong Kong and Canada raised the alarm after a projection model estimated that the prevalence of inflammatory bowel disease in the city would rise from 40 cases per 100,000 people in 2014 to 100 in 2034. 'The 150 per cent increase in the total number in terms of prevalence – this is quite scary,' said Professor Ng Siew Chien, associate dean of the Chinese University of Hong Kong's medical school and an expert in gastroenterology who co-led the study. 'We call this probably an explosion.' Researchers found that the rates were related to economic development and that less developed places, such as Malaysia and mainland China, had lower rates than Hong Kong, although they were also trending upwards. IBD refers to a group of conditions that cause swelling and inflammation of tissue in the digestive tract, with Crohn's disease and ulcerative colitis being the two most common types.
Medscape
19-05-2025
- Health
- Medscape
Winning Strategies to Retain Private Practice GIs
SAN DIEGO — With the recently updated recommendations by the US Preventive Services Task Force lowering the age for colorectal cancer screening to 45 instead of 50, an additional 19 million patients now require screening, Asma Khapra, MD, a gastroenterologist at Gastro Health in Fairfax, Virginia, told attendees at Digestive Disease Week (DDW) 2025. That change, coupled with the expected shortage of gastroenterologists, means one thing: The current workforce can't meet patient demand, she said. Private practices in particular face challenges in retaining gastroenterologists, Khapra added. The private practice model is already declining, she said. The fraction of US gastroenterologists in 'fully independent' private practice was about 30% in 2019, Khapra noted. Then, 'COVID really changed the landscape even more.' By 2022, 'that number has shrunk to 13%.' Meanwhile, 67% are employed gastroenterologists (not in private practice), 7% work in large group practices, and 13% are private equity (PE) backed. That makes effective retention strategies crucial for private practices, Khapra said. She first addressed the common attractions of private practices, then the challenges, and finally the winning strategies to retain and keep a viable private practice gastroenterology workforce. The Attractions of Private Practice The reasons for choosing private practice are many, Khapra said, including: Autonomy, Flexibility, Competitive compensation, Ownership mindset, Partnership paths, and Work-life balance including involvement in community and culture. On the other hand, private practices have unique challenges, including: Administrative burdens such as EHR documentation, paperwork, prior authorizations, and staffing issues, Financial pressures, including competition with the employment packages offered by hospitals, as reimbursements continue to drop and staffing costs increase, Burnout, Variety of buy-ins and partnership tracks, Limited career development, and The strains of aging and endoscopy. 'We used to joke in our practice that at any given time, three staff members are in physical therapy due to injuries and disabilities.' Employing the Iceberg Model One strategy, Khapra said, is to follow Edward T. Hall's Iceberg Model of Culture , which focuses on the importance of both visible and invisible elements. 'The key to retention in private practice is to develop a value system where everyone is treated well and respected and compensated fairly,' she said. 'That doesn't mean you split the pie [equally].' 'Visible' elements of the model include the physical environment, policies and practices, symbols and behaviors, she said. While under the surface ('invisible' elements) are shared values, perceptions and attitudes, leadership style, conflict resolution, decision making and unwritten rules. The key, she said, is to provide physicians an actual voice in decision making and to avoid favouritism, thus avoiding comments such as 'Why do the same two people always get the prime scoping blocks?' Financial transparency is also important, Khapra said. And people want flexibility without it being called special treatment. She provided several practical suggestions to accomplish the invisible Iceberg goals. For instance, she suggested paying for activities outside the practice that physicians do, such as serving on committees. If the practice can't afford that, she suggested asking the affiliated hospitals to do so, noting that such an initiative can often build community support. Paying more attention to early associates than is typical can also benefit the practice, Khapra said. 'So much effort is made to recruit them, and then once there, we're on to the next [recruits].' Instead, she suggested, 'pay attention to their needs.' Providing support to physicians who are injured is also crucial and can foster a community culture, she said. For example, one Gastro Health physician was out for 4 weeks due to complications from surgery. 'Everyone jumped in' to help fill the injured physician's shifts, she said, reassuring the physician that the money would be figured out later. 'That's the culture you want to instill.' To prevent burnout, another key to retaining physicians, 'you have to provide support staff.' And offering good benefits, including parental and maternal leave and disability benefits, is also crucial, Khapra said. Consider practices such as having social dinners, another way to build a sense of community. Finally, bring in national and local gastroenterologist organizations for discussions, including advocating for fair reimbursement for private practice. Consider working with the Digestive Health Physicians Alliance, which describes itself as the voice of independent gastroenterology, she suggested. More Perspectives Jami Kinnucan, MD, a gastroenterologist and associate professor of medicine at Mayo Clinic, Jacksonville , Florida, spoke about optimizing recruitment of young gastroenterologists and provided perspective on Khapra's talk. 'I think there's a lot of overlap' with her topic and retaining private practice gastroenterologists, she said in an interview with Medscape Medical News. Most important, she said, is having an efficient system in which the administrative flow is left to digital tools or other staff, not physicians. 'That will also help to reduce burnout,' she said, and allow physicians to do what they most want to do, which is to focus on providing care to patients. 'People want to feel valued for their work,' she agreed. 'People want opportunity for career development, opportunities for growth.' As gastroenterologists age, flexibility is important, as it in in general for all physicians, Kinnucan said. She suggested schedule flexibility as one way. For instance, 'if I tell 10 providers, 'I need you to see 100 patients this week, but you can do it however you want,' that promotes flexibility. They might want to see all of them on Monday and Tuesday, for instance. If you give people choice and autonomy, they are more likely to feel like they are part of the decision.' How do you build a high-functioning team? 'You do it by letting them operate autonomously,' and 'you let people do the things they are really excited about.' And always, as Khapra said, focus on the invisible elements that are so crucial.
Khaleej Times
16-05-2025
- Health
- Khaleej Times
NMC Specialty Hospital Abu Dhabi offers hope to Achalasia patients with advanced POEM procedure
The successful case underscores NMC Healthcare's commitment to excellence in clinical care and innovation In a major advancement for gastrointestinal care in the region, NMC Specialty Hospital, Abu Dhabi, has successfully performed a cutting-edge procedure to treat achalasia, a rare and progressive swallowing disorder using a minimally invasive endoscopic procedure known as POEM (Peroral Endoscopic Myotomy). The patient, a 23-year-old nurse, had been battling severe achalasia symptoms for several years. By the time she was referred to Dr Yogesh Shastri, consultant and head of the department of gastroenterology at NMC Specialty Hospital, her condition had significantly deteriorated. She was unable to eat or drink without extreme discomfort, had become severely malnourished and was relying on intravenous fluids. She also suffered from recurrent chest infections and experienced drastic weight loss, which had forced her to take indefinite leave from work. Achalasia, which affects approximately 1 in 100,000 people, occurs when the lower esophageal sphincter (LES) fails to relax, preventing food and liquids from entering the stomach. Over time, this leads to food accumulation in the esophagus resulting in regurgitation, malnutrition, chest pain and recurrent respiratory infections. If left untreated, the disorder can severely impact overall health and quality of life. Given the severity and complexity of her case, Dr. Shastri and his team opted for POEM - a scarless, natural orifice procedure performed entirely through the mouth without any skin incisions. The technique involves creating a narrow and long tunnel within the esophageal wall to precisely cut the tight or malfunctioning muscle to relieve the obstruction at the junction of food pipe and stomach. The procedure, known for its high success rate and faster recovery time, is considered a significant advancement compared to traditional and conventional surgical approaches. "POEM is especially beneficial and is standard of care in cases like this one, where other treatments such as balloon dilation or Botox injections are no longer viable," said Dr Shastri. "It allows for a tailored and precise muscle incision depending on the severity of the disease and provides long-lasting relief with minimal risk". The outcome of the endoscopic surgery was highly successful, and the patient's transformation was immediate. Within days of the procedure, she was able to eat and drink normally for the first time in months. Her strength and energy levels improved, she began regaining weight, and has since resumed her professional duties with renewed energy and optimism. "After everything I've been through, being able to drink water without fear and discomfort felt like being reborn," said the patient. "As a nurse, I understood the risks, but I also knew this was my only chance to reclaim my life. I'm beyond grateful to Dr. Shastri and the team at NMC." Reflecting on her journey, she added: "When I was at my lowest, even a sip of water felt impossible. Today, I can enjoy meals, socialise again, and return to doing what I love - caring for others - with a deeper compassion having experienced firsthand what it means to suffer. It feels like I've been given my life back." POEM remains a highly specialised procedure available only in select centers globally, requiring specialised training and advanced equipment. By offering the procedure locally, NMC Specialty Hospital is bridging a critical gap in care for achalasia patients across the UAE and the wider region and for patients who previously had to travel to countries like the US, Germany, India or South Korea. "At NMC Specialty Hospital, Abu Dhabi our focus is not just on treating disease, but restoring dignity and quality of life," added Dr. Shastri. "Innovations like POEM are at the heart of our mission to deliver world-class, patient centered care using the latest medical advancements". This successful case underscores NMC Healthcare's commitment to excellence in clinical care and innovation. As the hospital continues to invest in advanced procedures and multidisciplinary expertise, it offers renewed hope to patients facing rare and challenging conditions here in the UAE. For more information on NMC Healthcare, visit
