Latest news with #sacroiliitis
Medscape
23-06-2025
- Health
- Medscape
Do NSAIDs Affect Sacroiliitis Visibility on MRI in axSpA?
TOPLINE: Among patients with axial spondyloarthritis (axSpA) who showed active sacroiliitis on MRI after a washout of non-steroidal anti-inflammatory drugs (NSAIDs), complete resolution of MRI-visible sacroiliitis was seen in one fifth of cases, with close to half showing reduced inflammation after NSAID reintroduction. METHODOLOGY: Researchers conducted a non-randomised crossover trial across 34 centres in the UK between June 2017 and February 2020 to assess whether NSAIDs could mask active sacroiliitis on MRI in patients with axSpA. They recruited 311 patients with established or suspected axSpA and daily NSAID usage requiring sacroiliac joint MRI (median age, 42 years; 62% men; 87% White). Data on the clinical assessment were obtained. Participants underwent NSAID washout for 1-2 weeks before initial MRI (scan 1). Those who showed positive results for active sacroiliitis underwent a second scan (scan 2) at 6 weeks after resuming daily NSAIDs. Images were evaluated by two independent readers using the Leeds MRI scoring method, with scores suggesting no to severe sacroiliitis. The primary outcome was the proportion of patients with axSpA who had active sacroiliitis at scan 1 (off NSAIDs) that resolved at scan 2 after NSAIDs were reintroduced (on NSAIDs). TAKEAWAY: Among 286 patients who completed NSAID washout and underwent initial MRI, 146 showed active sacroiliitis, with follow-up scans obtained from 124 patients. Overall, 20.2% (95% CI, 13.5%-28.3%) of participants showed complete resolution of active sacroiliitis after NSAID reintroduction. Gender analysis showed no significant difference in the risk for sacroiliitis resolution between men and women. After NSAID reintroduction, 44% (95% CI, 35%-54%) of patients experienced a reduction in the Leeds score, suggesting improvement in severity. IN PRACTICE: "This provides evidence of the effect of NSAIDs on active sacroiliitis and shows that NSAID use prior to MRI may have an important impact on clinical diagnosis. Further, we show that, while patients may experience a deterioration in disease activity and spinal pain during NSAID washout, almost all patients who attempted NSAID washout were able to tolerate it. Thus, stopping NSAIDs for 1-2 weeks prior to MRI scanning in clinical practice should be considered," the authors wrote. SOURCE: This study was led by Gareth T. Jones, PhD, University of Aberdeen, Aberdeen, Scotland. It was published online on June 13, 2025, in Arthritis Care and Research. LIMITATIONS: The study protocol did not specifically state NSAID treatment, allowing participants to continue their prescribed medications and dosages. DISCLOSURES: This study received funding from Versus Arthritis. Five authors reported having financial ties, such as receiving grant support, honoraria, and consultancy, with multiple pharmaceutical companies, including AbbVie, Biogen, Eli Lilly, Novartis, Pfizer, UCB, Janssen, and others. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Asharq Al-Awsat
02-06-2025
- Health
- Asharq Al-Awsat
Courtois Out of Belgian Squad for World Cup Qualifiers
Belgium goalkeeper Thibaut Courtois has withdrawn from the squad for their opening two World Cup qualifiers this month because of a back injury. The player's club Real Madrid said on Sunday that he had been diagnosed with sacroiliitis -- inflammation of one or both sacroiliac joints in the area where the lower back and pelvis meet. "The medical staff of Real Madrid and the Royal Belgian Football Association have discussed Thibaut Courtois' back problems intensively in the past period," the Belgian association added in a statement. "Both medical staffs have come to the conclusion that the goalkeeper is not fit for the upcoming internationals." The injury may also jeopardize Courtois' chances of playing at the Club World Cup in the United States, where Real Madrid open their campaign in Miami on June 18 against Al Hilal from Saudi Arabia. Uncapped Nordin Jackers from Club Brugge will replace Courtois in the Belgian squad for the matches against North Macedonia in Skopje on Friday and at home to Wales next Monday. Nottingham Forest goalkeeper Matz Sels is expected to take Courtois' place in goal for the two Group J fixtures.
CNA
02-06-2025
- Health
- CNA
Courtois out of Belgian squad for World Cup qualifiers
Belgium goalkeeper Thibaut Courtois has withdrawn from the squad for their opening two World Cup qualifiers this month because of a back injury. The player's club Real Madrid said on Sunday that he had been diagnosed with sacroiliitis - inflammation of one or both sacroiliac joints in the area where the lower back and pelvis meet. "The medical staff of Real Madrid and the Royal Belgian Football Association have discussed Thibaut Courtois' back problems intensively in the past period,' the Belgian association added in a statement. "Both medical staffs have come to the conclusion that the goalkeeper is not fit for the upcoming internationals.' The injury may also jeopardise Courtois' chances of playing at the Club World Cup in the United States, where Real Madrid open their campaign in Miami on June 18 against Al Hilal from Saudi Arabia. Uncapped Nordin Jackers from Club Brugge will replace Courtois in the Belgian squad for the matches against North Macedonia in Skopje on Friday and at home to Wales next Monday.
CNA
01-06-2025
- General
- CNA
Belgium's Courtois doubtful for World Cup qualifiers due to back problem
Belgium's Real Madrid keeper Thibaut Courtois has been diagnosed with a back problem ahead of two World Cup qualifiers and the start of the Club World Cup, his LaLiga club said on Sunday. According to Spanish media, the 33-year-old requires a week of rest and treatment and will miss Belgium's opening Group J qualifiers away to North Macedonia on Friday and at home to Wales the following Monday. However, he should be available for Real Madrid's opening Club World Cup match against Al-Hilal in Miami on June 18. Courtois has been diagnosed with sacroiliitis, which is an inflammation of the joints connecting the lower spine to the pelvis, causing pain and stiffness in the back and hips.
Reuters
01-06-2025
- General
- Reuters
Belgium's Courtois doubtful for World Cup qualifiers due to back problem
June 1 (Reuters) - Belgium's Real Madrid keeper Thibaut Courtois has been diagnosed with a back problem ahead of two World Cup qualifiers and the start of the Club World Cup, his LaLiga club said on Sunday. According to Spanish media, the 33-year-old requires a week of rest and treatment and will miss Belgium's opening Group J qualifiers away to North Macedonia on Friday and at home to Wales the following Monday. However, he should be available for Real Madrid's opening Club World Cup match against Al-Hilal in Miami on June 18. Courtois has been diagnosed with sacroiliitis, which is an inflammation of the joints connecting the lower spine to the pelvis, causing pain and stiffness in the back and hips.
