Latest news with #CRP
Time of India
4 days ago
- Health
- Time of India
Lifestyle, not age alone, may be driving chronic inflammation
New Delhi: As you grow old, is inflammation of your system bothering you? It might not be just your age, as your lifestyle could also be responsible for it. A new study published in Nature Aging suggests that "inflammaging" — a chronic, low-grade inflammation commonly linked with ageing — may actually be a result of modern lifestyles rather than an inevitable part of growing old. Researchers from Columbia University's Mailman School of Public Health compared inflammation patterns in older adults from industrialised nations (Italy and Singapore) with those in indigenous populations living traditional lifestyles, such as the Tsimane in Bolivia and the Orang Asli in Malaysia. The contrast was striking. In industrialised populations, levels of inflammatory markers like C-reactive protein (CRP) and tumour necrosis factor rose steadily with age and were strongly associated with chronic illnesses like heart disease, kidney dysfunction and diabetes. By contrast, while Indigenous communities showed elevated inflammation due to constant exposure to infections, these markers did not increase with age, nor were they linked to similar rates of chronic disease. You Can Also Check: Delhi AQI | Weather in Delhi | Bank Holidays in Delhi | Public Holidays in Delhi "Inflammaging may not be a direct result of ageing, but rather a response to industrialised environments," explained Dr Alan Cohen, associate professor of environmental health sciences at Columbia University and faculty member of Butler Columbia Aging Center. "Our immune systems evolved under very different conditions than those we live in now." Health experts echo these findings, warning that a host of modern factors, including processed diets, sedentary lifestyles, environmental pollution, chronic stress and poor sleep, are major contributors to persistent inflammation. "In industrialised societies, inflammation is largely sterile and ongoing, caused by metabolic changes and immune dysfunction—not infections," said Dr Richa Chaturvedi, senior consultant, endocrinology, Indraprastha Apollo Hospitals. "In contrast, in traditional societies, inflammation is mostly infection-related and doesn't necessarily lead to long-term disease." Dietician Anjali Bhola from NCI Jhajjar, AIIMS, noted that diets high in sugar, salt, and refined carbs, coupled with erratic sleep and chronic stress, disrupt gut health and raise inflammatory markers. "These factors not only speed up biological ageing but also heighten the risk of non-communicable diseases," she said. Maj. Gen. Dr Darshan Singh Bhakuni, senior director, rheumatology, Max Super Speciality Hospital, echoed this. "Inflammation in Indigenous groups is typically driven by infections but doesn't worsen with age. This suggests that inflammation may reflect infectious burden more than biological ageing." "In communities such as the Tsimane and Orang Asli, ongoing exposure to infections keeps inflammation high at all ages," said Dr Setu Gupta, associate consultant, endocrinology & metabolism, Sir Ganga Ram Hospital. "But unlike in industrialised societies, this inflammation doesn't increase with age or lead to chronic diseases." Dr Parjeet Kaur, associate director, endocrinology & diabetes, Medanta, Gurugram, explained that while infectious inflammation is usually acute and short-lived, inflammaging is ongoing and driven by non-infectious factors. "The two involve similar immune pathways, but their triggers and outcomes are different," she said. So, can inflammaging be prevented? Experts believe it can be managed—and even reversed—with the right lifestyle changes. Dr Bhola advises a high-fibre, high-protein, low-carb diet with limited salt and sugar, 2 to 2.5 litres of water daily, and foods rich in zinc, vitamin C, vitamin D, and iron. She also emphasises regular moderate exercise, 7–9 hours of quality sleep, and stress-reduction techniques such as yoga and mindfulness. The study reinforces a powerful message: ageing itself may not be the main cause of chronic inflammation—how we live might be. Healthier ageing, it seems, begins with rethinking the way we eat, move and rest. Stay updated with the latest local news from your city on Times of India (TOI). Check upcoming bank holidays , public holidays , and current gold rates and silver prices in your area. Get the latest lifestyle updates on Times of India, along with Raksha Bandhan wishes , messages and quotes !
Time of India
5 days ago
- Health
- Time of India
The link between PCOS and cardiovascular disease: What every woman should know
Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder affecting about 10% of women of reproductive age globally. Characterized by hormonal imbalances, irregular menstrual cycles, and metabolic issues such as insulin resistance and obesity, PCOS can lead to various health complications. Beyond reproductive concerns, emerging research highlights a strong link between PCOS and increased risk of cardiovascular disease (CVD). Women with PCOS often experience factors like high blood pressure, dyslipidemia, chronic inflammation, and endothelial dysfunction, which contribute to heart disease and stroke risk. Early awareness, lifestyle changes, and medical management are crucial to reducing these cardiovascular risks. What is PCOS and how it increases cardiovascular risk in women PCOS is characterised by hormonal imbalances that can lead to irregular menstrual cycles, elevated levels of androgens (male hormones), and polycystic ovaries. Common symptoms include: Irregular periods Ovulatory dysfunction Elevated androgen levels Cystic ovaries Beyond reproductive health, PCOS is linked to metabolic disturbances such as insulin resistance, obesity, and dyslipidemia, which can contribute to cardiovascular risk. PCOS increases cardiovascular risk 1. Metabolic syndrome Women with PCOS often exhibit components of metabolic syndrome, including: Insulin resistance: Leading to elevated blood glucose levels. Dyslipidemia: Characterized by high LDL cholesterol and triglycerides, and low HDL cholesterol. Hypertension: Increased blood pressure levels. These factors collectively elevate the risk of cardiovascular events such as heart attacks and strokes . by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Free P2,000 GCash eGift UnionBank Credit Card Apply Now Undo 2. Chronic inflammation PCOS is associated with low-grade chronic inflammation, as evidenced by elevated levels of inflammatory markers like C-reactive protein (CRP) and interleukins. This inflammatory state can accelerate the development of atherosclerosis, a condition where plaque builds up in the arteries, leading to cardiovascular complications . 3. Endothelial dysfunction The endothelium, the thin layer of cells lining blood vessels, plays a crucial role in vascular health. Women with PCOS often exhibit endothelial dysfunction, characterized by reduced nitric oxide availability and impaired vasodilation. This dysfunction contributes to increased arterial stiffness and heightened cardiovascular risk . 4. Obstructive Sleep Apnea (OSA) OSA is more prevalent in women with PCOS compared to the general population. The intermittent cessation of breathing during sleep can lead to increased blood pressure and elevated sympathetic nervous system activity, further exacerbating cardiovascular risk . Does weight matter? While obesity can elevate the risk of PCOS and its complications, it's a myth that only overweight or obese women are affected. Even women with a healthy or lean body weight can experience insulin resistance, abnormal lipid profiles, and high blood pressure due to PCOS. This makes it essential to monitor cardiovascular health markers in all women with PCOS, regardless of their body size. Preventive measures and management 1. Regular monitoring Routine screening for cardiovascular risk factors is essential for women with PCOS. This includes: Monitoring blood pressure Assessing lipid profiles Evaluating glucose tolerance 2. Lifestyle modifications Adopting a heart-healthy lifestyle can mitigate cardiovascular risk: Diet: Emphasize a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. The DASH (Dietary Approaches to Stop Hypertension) diet is particularly beneficial for managing blood pressure. Physical activity: Engage in regular aerobic exercises to improve cardiovascular health and manage weight. Weight management: Achieve and maintain a healthy weight to reduce insulin resistance and improve lipid profiles. 3. Pharmacological interventions In some cases, medications may be prescribed to manage cardiovascular risk factors. 4. Sleep apnea management For women with PCOS diagnosed with OSA, appropriate interventions like Continuous Positive Airway Pressure (CPAP) therapy can improve sleep quality and reduce cardiovascular strain. Also read | PCOD diet: Best foods, what to avoid, and lifestyle tips to manage PCOD naturally
Business Wire
6 days ago
- Business
- Business Wire
KBRA Assigns Preliminary Ratings to Towd Point Mortgage Trust 2025-CES3 (TPMT 2025-CES3)
NEW YORK--(BUSINESS WIRE)--KBRA assigns preliminary ratings to 40 classes of asset-backed securities from Towd Point Mortgage Trust 2025-CES3 (TPMT 2025-CES3), a $464.3 million RMBS transaction, as of the Cut-off Date, sponsored by CRM 2 Sponsor, LLC and FirstKey Mortgage, LLC (FirstKey). The underlying pool consists of 5,136 closed-end second lien mortgages (CES; 100%) originated by Spring EQ, LLC (Spring EQ; 58.1%), Rocket Mortgage, LLC (Rocket; 21.2%), and NewRez LLC (NewRez; 20.7%). The CES collateral is characterized by fully amortizing, fixed-rate mortgages (FRMs) with a non-zero weighted average original credit score of 738 and an average original term of 245 months and is seasoned approximately one months. To access ratings and relevant documents, click here. Click here to view the report. Methodologies RMBS: U.S. RMBS Rating Methodology Structured Finance: Global Structured Finance Counterparty Methodology ESG Global Rating Methodology Disclosures Further information on key credit considerations, sensitivity analyses that consider what factors can affect these credit ratings and how they could lead to an upgrade or a downgrade, and ESG factors (where they are a key driver behind the change to the credit rating or rating outlook) can be found in the full rating report referenced above. A description of all substantially material sources that were used to prepare the credit rating and information on the methodology(ies) (inclusive of any material models and sensitivity analyses of the relevant key rating assumptions, as applicable) used in determining the credit rating is available in the Information Disclosure Form(s) located here. Information on the meaning of each rating category can be located here. Further disclosures relating to this rating action are available in the Information Disclosure Form(s) referenced above. Additional information regarding KBRA policies, methodologies, rating scales and disclosures are available at About KBRA Kroll Bond Rating Agency, LLC (KBRA), one of the major credit rating agencies (CRA), is a full-service CRA registered with the U.S. Securities and Exchange Commission as an NRSRO. Kroll Bond Rating Agency Europe Limited is registered as a CRA with the European Securities and Markets Authority. Kroll Bond Rating Agency UK Limited is registered as a CRA with the UK Financial Conduct Authority. In addition, KBRA is designated as a Designated Rating Organization (DRO) by the Ontario Securities Commission for issuers of asset-backed securities to file a short form prospectus or shelf prospectus. KBRA is also recognized as a Qualified Rating Agency by Taiwan's Financial Supervisory Commission and is recognized by the National Association of Insurance Commissioners as a Credit Rating Provider (CRP) in the U.S. Doc ID: 1010724
Daily Mirror
29-07-2025
- Politics
- Daily Mirror
Dramatic video shows officers rushing to 'targeted' quadruple Southwark stabbing
Two men - aged 58 and 27 - were killed in a lunchtime office knife rampage during what an MP has described as a 'targeted' attack that left four people injured in central London Dramatic footage shows police rushing to the scene of a quadruple stabbing that killed two people in what has been described as a "targeted" attack. Officers were called at 1pm on Monday after the knife-rampage at a business premises in central London. Video taken from opposite the building shows officers carrying first aid equipment dashing to treat the victims while two paramedics follow with a stretcher. A 58-year-old man died at the scene in Long Lane, close to London Bridge, and three others were rushed to hospital. They included a 27-year-old man who later died from his stab wounds. The Met Police said on Tuesday that at 31-year-old man from Hackney, east London, had been arrested on suspicion of murder. He remains in hospital. Another man in his thirties is also still being treated and his injuries are not believed to be life-threatening or life-changing. Dramatic video footage from the scene captures the scale of the massive police response, showing multiple cars rolling up to the London neighbourhood before multiple officers rush inside the building where the stabbings took place. The series of brief clips shows both police and ambulance vehicles lined down the leafy street while locals gather outside a police cordon. A number of officers can be seen standing guard outside. Speaking at the scene, Labour MP Neil Coyle, who represents the Bermondsey and Old Southwark constituency where the incident occurred, said: 'This was a targeted attack and there is no risk to the wider community. It's thought the individual worked for the business and were known to each other. I'll be sending letters to 1,000 constituents to reassure them. 'But we know this is a safe area and this was a targeted attack.' Mr Coyle said he did not know the motive for the attack. Asked if he had spoken to relatives of the victims, he said: 'No. The family have a lot to deal with'. He added that police and paramedics 'tried desperately' to save the lives of the victims. A neighbour who lives opposite where the attack took place watched the drama unfold from his window and said one victim was given CRP for "a long time" at the scene. The building is the headquarters to Prospira Global, a business consultancy firm specialising in mental health support, property investors Trademark Group and local residents. A resident who was working from home inside his flat yesterday said he heard someone scream 'Help me!'. Mario Sergio, 32, said: "We just looked out the window when we saw the police, we watched as they closed the road and were running into the building. Then they brought the guy out on the bed and I had to look away. They were working on him for a long time, hours it felt like." Another resident, who did not wish to be named, returned from work to find his building blocked off by police tape and a heavy police presence on the road. Det Chief Supt Emma Bond, who leads policing for the area, said: 'Our investigation is in the early stages and we are working hard to understand the full circumstances of this shocking incident. At this point, we do not believe it to be terrorism-related and there is no further risk to the public." Police forensics teams could be seen entering the building at the scene where the attack took place. A local described seeing blood on the floor and walls outside an office in the premises.
Indian Express
29-07-2025
- Business
- Indian Express
IBPS CRP CSA-XV: Registration for 2026-27 bank vacancies begins on August 1
The Institute of Banking Personnel Selection (IBPS) will start the application for the Common Recruitment Process (CRP) for Customer Service Associates (CSA) in participating public sector banks for the 2026-27 vacancies on August 1. The online registration process will continue till August 21. The previous designation of IBPS Clerk has been changed to CSA and this change in designation was effective from April 1, 2024. Interested aspirants can visit the official website of IBPS – for detailed notifications, updates, and instructions. Any queries or complaints can be addressed through the IBPS helpdesk portal at As per the official advertisement published in Employment News (August 2 to 8, 2025 edition), candidates can apply and modify their IBPS Clerk applications within the same period. The payment of application fees and intimation charges will also be open during this period. Pre-exam training for eligible candidates is tentatively scheduled for September. The recruitment process involves an online preliminary examination set to be held in October, followed by the main examination in November. The results of the preliminary exam are expected in October or November 2025, with provisional allotment of selected candidates planned for March 2026. Since recruitment in the clerical cadre in Public Sector Banks is done on a State/UT-wise basis, candidates can apply for vacancies in any one State/ UT only. Consequently, a candidate would be required to appear for Online Examination in any one of the centres in that particular State/UT. However, depending upon the response, administrative feasibility etc. candidates may be allotted to a centre of examination outside the chosen State/UT for which vacancies he/she is applying.
