Cubs at Cardinals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for August 8
The Cardinals are coming off a series victory against the Dodgers where they took two out of three compared to the Cubs who dropped two of three to the Reds. The Cubs own the season series 4-3 over the Cardinals and are coming in with a better second-half record.
Let's dive into the matchup and find a sweat or two. We've got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Cubs at Cardinals
Date: Friday, August 8, 2025
Time: 8:15PM EST
Site: Busch Stadium
City: St. Louis, MO
Network/Streaming: MARQ, FDSNMW, MLBN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Cubs at the Cardinals
The latest odds as of Friday:
Moneyline: Cubs (-153), Cardinals (+128)
Spread: Cubs -1.5
Total: 8.0 runs
Probable starting pitchers for Cubs at Cardinals
Pitching matchup for August 8, 2025: Matthew Boyd vs. Michael McGreevy
Cubs: Matthew Boyd, (11-4, 2.34 ERA)Last outing: 0.00 ERA, 0 Earned Runs Allowed, 4 Hits Allowed, 0 Walks, and 8 Strikeouts
Cardinals: Michael McGreevy, (3-2, 5.08 ERA)Last outing: 6.00 ERA, 4 Earned Runs Allowed, 7 Hits Allowed, 1 Walks, and 4 Strikeouts
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Expert picks & predictions for tonight's game between the Cubs and the Cardinals
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Friday's game between the Cubs and the Cardinals:
Moneyline: NBC Sports Bet is recommending a play on the Chicago Cubs on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the St. Louis Cardinals at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Cubs at Cardinals
St. Louis is 7-12 since the All-Star break
Chicago is 9-9 since the All-Star break
Chicago is 4-3 versus St. Louis this season
The Cubs have won five of their last seven road matchups against teams with worse records
Five of the Cubs' last six road games have gone over the total
The Cardinals have failed to cover the run line in four of their last five home games
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Follow our experts on socials to keep up with all the latest content from the staff:
Jay Croucher (@croucherJD)
Drew Dinsick (@whale_capper)
Vaughn Dalzell (@VmoneySports)
Trysta Krick (@Trysta_Krick)
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