
Wait, is your body rejecting your relationship?
You've probably questioned some of these signals before with friends over dinner, or maybe you saw them in a viral January 2025 Thread asking the question: 'Girlies, how did you know your body was rejecting your ex?'
About 2,000 people flocked to the comment section to share a range of physical and mental health symptoms they experienced in problematic relationships, including nausea, yeast infections, chronic UTIs, bacterial vaginosis, weight fluctuations, pain during sex, depression, anxiety, and more. Of course, all these issues could be attributed to more than just bad relationships, but let's be clear: this is also 100 per cent a real thing your body does.
'Toxic relationships can lead to toxic bodies,' says psychologist Candice Nicole Hargons, PhD, an associate professor at Emory University's Rollins School of Public Health.
Your body is constantly responding to your environment, including your relationships, adds licensed marriage and family therapist Cheryl Groskopf. 'When you're in one that feels unsafe, inconsistent, or emotionally draining, your nervous system reacts.'
This is exactly what happened to Stephanie* when she experienced her first migraine nearly one year into dating her former boyfriend. The headaches were nonstop and resistant to every remedy she tried, from prescription painkillers to holistic approaches like acupuncture, reflexology, and deep-tissue massages. 'I met with every specialist under the moon,' she says. Clarity finally came during therapy, a safe space where she would regularly vent about her boyfriend. 'I was in agony and my therapist wondered if my body was rebelling against him,' she remembers. Once Stephanie became single, her migraines let up.
The tricky thing is that doctors can brush off these symptoms or attribute them to something else - almost anything, really, because such physical and emotional signs could be explained by many other conditions, says Groskopf. A lot of times, physicians chalk them up to 'just stress,' and while they're not wrong, the source of that stress is important, too.
'When a relationship triggers nonstop stress, your nervous system is always over-activated,' says Groskopf. 'Your body perceives the relationship as a threat, even if you don't consciously think of it that way. If symptoms improve when you're alone, around supportive people, or after time away from your partner, that's a strong indicator that your relationship is the cause.'
The problems in your relationship don't have to be extreme or abusive for this to be the case. Stephanie says her relationship 'sucked' but not in the way people typically think. 'He wasn't showing up for me emotionally and we just didn't gel. The headaches were how my body was letting me know he wasn't as good as it gets.'
Six months after separating from her now ex-husband, Allison* says she finally 'looked like me again.' While married, she dealt with a lot of abandonment, emotional stonewalling, and cold-shouldering that stemmed from her ex's gambling problem. 'My unhappiness literally showed on my face,' she says. She was constantly puffy and acne-prone, and her skin was irritated. She hadn't gained weight, changed anything in her diet, or started a new medication—there was no explanation for it... until the marriage was over.
Experiencing symptoms like this doesn't mean you have to end things immediately, says Groskopf. Sometimes, the symptoms can go away after a couple addresses their concerns. Other times, performing micro-experiments, like taking some space before going through with a full-fledged breakup, may give you better insight as well.
It can be easy to lose yourself in any kind of relationship, but the most important thing you can do first and foremost is get to know and prioritise yourself. Listen to your body—it's sending you these signals, ultimately, as a way to try and keep you safe.
Many experts suggest developing some sort of mindfulness practice, like breathwork or regular therapy, before you're in a relationship so that you can be more in tune with your body's 'normal.' This can help you identify when someone in your life throws it off. 'Check in with your emotions before your body has to scream for your attention,' says Groskopf.
That can be easier said than done, so logging symptoms and feelings in a journal or in your Notes app is a practical and helpful way to track patterns. It will be a good reference for you and your health care providers, too. Paying attention to when symptoms strike is also key intel. You'll be able to establish your baseline and know what your body does and feels like when it's neutral, excited, or experiencing negative changes—so you can work toward a goal of overall well-being, including the romantic kind.
As Hargons says: 'When your relationship is a healthy, happy one, you have better health overall.'
Gabrielle Kassel (she/her) is a sex and wellness journalist who writes at the intersection of queerness, sexual health, and pleasure. In addition to Women's Health, her work has appeared in publications such as Shape, Cosmopolitan, Well+Good, Health, Self, Men's Health, Greatist, and more! In her free time, Gabrielle can be found coaching CrossFit, reviewing pleasure products, hiking with her border collie, or recording episodes of the podcast she co-hosts called
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Cosmopolitan
4 days ago
- Cosmopolitan
Wait, is your body rejecting your relationship?
Pop culture likes to romanticise steamy, flawed connections to the point where passionate yet toxic dynamics have come to seem normal to impressionable audiences (see: Babygirl or Fifty Shades of Grey). This kind of desensitisation can bleed over into real life, making it harder to realise when a relationship has gone sour. Luckily, we all have something in our corner capable of signalling when it's truly time to move on: if only we knew how to listen. You've probably questioned some of these signals before with friends over dinner, or maybe you saw them in a viral January 2025 Thread asking the question: 'Girlies, how did you know your body was rejecting your ex?' About 2,000 people flocked to the comment section to share a range of physical and mental health symptoms they experienced in problematic relationships, including nausea, yeast infections, chronic UTIs, bacterial vaginosis, weight fluctuations, pain during sex, depression, anxiety, and more. Of course, all these issues could be attributed to more than just bad relationships, but let's be clear: this is also 100 per cent a real thing your body does. 'Toxic relationships can lead to toxic bodies,' says psychologist Candice Nicole Hargons, PhD, an associate professor at Emory University's Rollins School of Public Health. Your body is constantly responding to your environment, including your relationships, adds licensed marriage and family therapist Cheryl Groskopf. 'When you're in one that feels unsafe, inconsistent, or emotionally draining, your nervous system reacts.' This is exactly what happened to Stephanie* when she experienced her first migraine nearly one year into dating her former boyfriend. The headaches were nonstop and resistant to every remedy she tried, from prescription painkillers to holistic approaches like acupuncture, reflexology, and deep-tissue massages. 'I met with every specialist under the moon,' she says. Clarity finally came during therapy, a safe space where she would regularly vent about her boyfriend. 'I was in agony and my therapist wondered if my body was rebelling against him,' she remembers. Once Stephanie became single, her migraines let up. The tricky thing is that doctors can brush off these symptoms or attribute them to something else - almost anything, really, because such physical and emotional signs could be explained by many other conditions, says Groskopf. A lot of times, physicians chalk them up to 'just stress,' and while they're not wrong, the source of that stress is important, too. 'When a relationship triggers nonstop stress, your nervous system is always over-activated,' says Groskopf. 'Your body perceives the relationship as a threat, even if you don't consciously think of it that way. If symptoms improve when you're alone, around supportive people, or after time away from your partner, that's a strong indicator that your relationship is the cause.' The problems in your relationship don't have to be extreme or abusive for this to be the case. Stephanie says her relationship 'sucked' but not in the way people typically think. 'He wasn't showing up for me emotionally and we just didn't gel. The headaches were how my body was letting me know he wasn't as good as it gets.' Six months after separating from her now ex-husband, Allison* says she finally 'looked like me again.' While married, she dealt with a lot of abandonment, emotional stonewalling, and cold-shouldering that stemmed from her ex's gambling problem. 'My unhappiness literally showed on my face,' she says. She was constantly puffy and acne-prone, and her skin was irritated. She hadn't gained weight, changed anything in her diet, or started a new medication—there was no explanation for it... until the marriage was over. Experiencing symptoms like this doesn't mean you have to end things immediately, says Groskopf. Sometimes, the symptoms can go away after a couple addresses their concerns. Other times, performing micro-experiments, like taking some space before going through with a full-fledged breakup, may give you better insight as well. It can be easy to lose yourself in any kind of relationship, but the most important thing you can do first and foremost is get to know and prioritise yourself. Listen to your body—it's sending you these signals, ultimately, as a way to try and keep you safe. Many experts suggest developing some sort of mindfulness practice, like breathwork or regular therapy, before you're in a relationship so that you can be more in tune with your body's 'normal.' This can help you identify when someone in your life throws it off. 'Check in with your emotions before your body has to scream for your attention,' says Groskopf. That can be easier said than done, so logging symptoms and feelings in a journal or in your Notes app is a practical and helpful way to track patterns. It will be a good reference for you and your health care providers, too. Paying attention to when symptoms strike is also key intel. You'll be able to establish your baseline and know what your body does and feels like when it's neutral, excited, or experiencing negative changes—so you can work toward a goal of overall well-being, including the romantic kind. As Hargons says: 'When your relationship is a healthy, happy one, you have better health overall.' Gabrielle Kassel (she/her) is a sex and wellness journalist who writes at the intersection of queerness, sexual health, and pleasure. In addition to Women's Health, her work has appeared in publications such as Shape, Cosmopolitan, Well+Good, Health, Self, Men's Health, Greatist, and more! In her free time, Gabrielle can be found coaching CrossFit, reviewing pleasure products, hiking with her border collie, or recording episodes of the podcast she co-hosts called
Yahoo
23-07-2025
- Yahoo
Male birth control pill passes early safety test, with more trials underway
When you buy through links on our articles, Future and its syndication partners may earn a commission. An experimental, hormone-free male birth control pill has just passed its first safety test in humans. The trial included 16 people and was only intended to test whether the drug reached adequate levels in the body, as well as whether it triggered any serious side effects, such as concerning changes in heart rate, hormone function, inflammation, mood or sexual function. Across the doses tested, no significant side effects were observed. That result tees up the pill to be tested in larger trials that will now look at both safety and efficacy. The results of the early safety trial, published Tuesday (July 22) in the journal Communications Medicine, are a critical first step toward getting the pill approved, Dr. Stephanie Page, an endocrinologist at the University of Washington School of Medicine who wasn't involved in the study, told Scientific American. "We really need more reversible contraceptive methods for men," she added. For the moment, the only male birth control options are condoms and vasectomies. The latter can be reversed, but the actual success rate of the reversal procedure varies widely in terms of how likely a person is to conceive a child afterward. If approved, the new pill would be the first drug in its class. "A safe and effective male pill will provide more options to couples for birth control," Gunda Georg, a professor in the University of Minnesota College of Pharmacy, where the drug molecule was developed, said in a statement released earlier this year following promising preclinical testing of the pill. Columbia University was also involved in the drug's development, along with the company YourChoice Therapeutics, which is overseeing the trials. Related: Why is there still no male birth control pill? "It will allow a more equitable sharing of responsibility for family planning and provide reproductive autonomy for men," Georg said. How the male birth control pill works The experimental pill, called YCT-529, is designed to pause sperm production by interrupting specific signals in the body. Specifically, the drug works by blocking a protein called "retinoic acid receptor alpha," which is known to play a key role in the formation and maturation of sperm. In the testes, the receptor would usually be activated by the insertion of a "key" — a vitamin A metabolite — but the drug stops this key from clicking into place. That, in turn, prevents the chain reaction that ends with sperm being made. Finding a compound with this effect required the scientists to closely examine the structure of the receptor when it's bound to its key, as well as test dozens of molecules to see which could block the interaction. In preclinical tests with male lab mice, the drug "elicited profound effects" on sperm production. It triggered reversible infertility within four weeks of use, showing 99% effectiveness at preventing pregnancy in the female mice the treated males mated with. When taken off the drug, the male mice's fertility was restored within about four to six weeks. Further tests in nonhuman primates returned similar results, with sperm counts falling dramatically within two weeks of starting the drug and fully recovering within 10 to 15 weeks of stopping the drug. These preclinical tests set the stage for the recent clinical trial in people. The trial included 16 males ages 32 to 59, all of whom had previously undergone vasectomies. This was done out of an abundance of caution, in case the experimental drug was to have any lasting impacts on fertility, Nadja Mannowetz, co-founder and chief science officer of YourChoice Therapeutics, told Scientific American. The participants were split into groups who received either placebo pills or a low or high dose of the drug. Most of the participants took the pill only after a period of fasting, but a subset were also given doses after a large meal, to see if that affected levels of the drug in the body. Across all of the doses and conditions tested, the levels of the drug in the body reached decent levels, but Mannowetz anticipates that, if approved, the final dose would be closest to the highest one tested: 180 milligrams. RELATED STORIES —Hormonal birth control may double risk of stroke, study finds —1st over-the-counter birth control pill approved by FDA —Blood clot risk linked to taking common painkillers alongside certain hormonal birth control Both the animal study and the human trial results suggest that the approved pill would likely be taken once a day, but further trials will confirm that dosing. And although no notable side effects emerged in this small trial, future trials with larger study cohorts will still need to monitor for these effects. "The positive results from this first clinical trial laid the groundwork for a second trial, where men receive YCT-529 for 28 days and 90 days, to study safety and changes in sperm parameters," the study authors wrote in their paper. That trial is already underway and again is looking at males who have already had vasectomies or who have made a firm decision not to father children. This article is for informational purposes only and is not meant to offer medical advice.


Medscape
22-07-2025
- Medscape
Healthcare Access, Geography Predict HIV in Black Women
Limited healthcare access and sociostructural factors were stronger predictors of HIV than behavioral risk factors among Black women in the southern United States, based on modeling data from more than 300,000 women in or near Atlanta, Georgia. The findings were presented in a late-breaker study at the International AIDS Society Conference on HIV Science. Nonbehavioral factors such as structural and social determinants of health can complicate HIV risk assessment, wrote Meredith Lora, MD, of Emory University, Atlanta, and colleagues. Previous risk prediction models have underperformed in Black women, whose HIV risk is approximately 20 times that of White women, the researchers wrote. To better assess HIV risk in Black women, the researchers used machine learning to create a model that analyzed electronic medical records data from all women treated at a single center in Atlanta between 2012 and 2022. The study population included 333,263 women; 617 (0.19%) had incident HIV diagnoses and 89% of those with HIV identified as Black individuals. The model included features with a prevalence of 5% or higher in the electronic medical records data and included novel structural determinant features and healthcare utilization features. Overall, the top predictors of HIV included younger age, Black race, residing in high HIV incidence zip codes, and at least one change in phone number or address prior to HIV diagnosis. In addition, women who underwent more HIV screening tests were more likely to be diagnosed with HIV, and women with HIV were more likely than those without HIV to seek care in an emergency department (ED) vs primary care or women's healthcare settings. Although more women with HIV tested positive for sexually transmitted infectious compared to those without HIV in the 2 years before diagnosis, 'seeking sexual health was more important to the model than STI positivity,' the researchers wrote. The model achieved a test area under the receiver operating characteristic curve (AUROC) of 0.90 and area under a precision-recall curve (AUPRC) of 0.14. The appearance of frequent HIV testing as a predictor of risk suggests the presence of undisclosed risk factors that may merit further investigation, the researchers noted in their abstract. EHR models designed for racially diverse female populations may identify more candidates for pre-exposure prophylaxis (PrEP), but that is not enough, the researchers emphasized. 'Evaluating how these models are implemented to support PrEP uptake and behavior change is critical for real-world impact,' they concluded. Assistance in Risk Assessment The current study is important given the traditional and historical difficulty of women in the United States in predicting their own risk of HIV, said Monica Gandhi, MD, director of the University of California San Francisco Bay Area Center for AIDS Research, and a professor of medicine at UCSF, in an interview. Gandhi cited a recent study from the CDC showing that more than 2.2 million individuals in the US need PrEP, but only 336K have received prescriptions. 'Women may not be able to adjudicate their own risk of HIV, as that risk depends on the risk in their male sexual partners,' said Gandhi, who was not involved in the current study or the CDC study. 'Machine learning using electronic medical records [EMR] can make risk prediction more accurate by reporting both health and social factors,' she noted. The current study identified predictors of HIV risk using extracted EMR data, that the healthcare system may be able to mitigate, she said. 'I was surprised by the fact that seeking sexual health was a stronger predictor of HIV than STD positivity, which indicates that women actually are more aware of their risk for HIV in the US than suggested in previous studies that usually involved smaller sample sizes, Gandhi told Medscape Medical News . 'I was also surprised that women with frequent changes in address or phone number had higher risk,' she said. This suggests mobility as a risk factor, which has been identified more commonly in sub-Saharan Africa, she noted. However, Gandhi was not surprised by the preference for ED care or the increased HIV risk among Black women vs other races, both of which have implications for HIV prevention, she said. The preference for sexual health care in the ED setting in the study population suggests that the ED is an important setting in which to perform STD testing and start PrEP or set up an individual with HIV prevention services, said Gandhi. 'Designated PrEP services for women in historically Black neighborhoods are indicated, and women who are mobile and change their address or phone number frequently should be counseled on HIV prevention modalities, specifically PrEP,' she added. Looking ahead, qualitative research is needed to ask a subset of women with HIV who presented to the ED for sexual health services why they chose the ED; this could help inform how to re-engage women in care, Gandhi said. Additional research on women's knowledge of PrEP and whether women with HIV were offered PrEP in the past also would help identify more opportunities for HIV prevention, she said.