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Billion euro deal: Sanofi buys UK biotech company to expand respiratory vaccine portfolio

Billion euro deal: Sanofi buys UK biotech company to expand respiratory vaccine portfolio

Yahoo2 days ago
In the race to develop next-generation respiratory virus vaccines, French pharmaceutical company Sanofi has agreed to buy Vicebio Ltd., a privately-held biotechnology company headquartered in London, UK.
Sanofi said there will be an initial cash payment of $1.15bn (€980 million) for the deal, 'with potential milestone payments of up to $450 million based on development and regulatory achievements'.
'We are excited to join Sanofi', said Emmanuel Hanon, Chief Executive Officer at Vicebio, in a statement. 'Their global scale and deep expertise in vaccine development provide the ideal environment to fully realise the potential of our innovative technology."
With the acquisition, Sanofi gets Vicebio's early-stage combination vaccine candidate for two respiratory viruses, the respiratory syncytial virus (RSV) and human metapneumovirus (hMPV).
Respiratory infections, affecting millions globally, often appear as cold-like illnesses that could, in severe cases, lead to pneumonia.
In respiratory medication, Sanofi already has several vaccines in its portfolio against flu and RSV prevention; this latest acquisition adds a non-mRNA vaccine to its pipeline. mRNA technology is relatively new for vaccines. It teaches the body how to make a protein that triggers an immune response to protect against a specific virus, instead of using a weakened or inactivated germ to trigger this reaction.
With the current deal, Sanofi also gets access to Vicebio's Molecular Clamp technology, which stabilises viral proteins in their native shape, triggering a more effective immune response. This technology is expected to speed up vaccine development and simplify manufacturing and distribution.
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Doliprane-maker Sanofi confirms exclusive talks with US firm CD&R
'This acquisition furthers Sanofi's dedication to vaccine innovation with the potential to develop next-generation combination vaccines that could provide protection to older adults against multiple respiratory viruses with a single immunisation," said Jean-François Toussaint, global head of research and development vaccines at Sanofi.
The transaction is expected to close by the end of 2025, and will not have a significant impact on Sanofi's financial guidance for 2025. The pharma giant's share price was down around 0.4% before 11:00 CEST in Paris.
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Pierre & Vacances-Center Parcs: Third-Quarter 2024/2025 Revenue
Pierre & Vacances-Center Parcs: Third-Quarter 2024/2025 Revenue

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Pierre & Vacances-Center Parcs: Third-Quarter 2024/2025 Revenue

Q3 2024/2025 economic revenue from tourism businesses up 12.2%and up 3.7% over the first nine months of the financial year, bringing Group revenue to €1,294 million. Confirmation of 2024/2025 outlook1:Adjusted EBITDA2 expected to reach more than €180 million, an increase on the previous year's level.(€163 million in 2023/2024, excluding the impact of non-recurring income3). PARIS, July 24, 2025--(BUSINESS WIRE)--Regulatory News: Franck Gervais, CEO of Pierre & Vacances-Center Parcs (Paris:VAC), stated: "In a difficult and volatile environment, growth in Group revenue from the tourism businesses stood at almost 4% over the first nine months of the financial year, with strong momentum across all brands and a constant increase in satisfaction rates. Third-quarter revenue was particularly robust, with significant last-minute sales flows and an increase in key performance indicators, both occupancy rates and average letting rates. Growth in reservations accumulated to date for the summer period, combined with the 12% increase in third-quarter revenue, add weight to our guidance for full-year EBITDA of more than €180 million. At the same time, the Group is continuing to review its strategic options to ambitiously approach a new stage of its story". 1] Revenue Under IFRS accounting, Q3 2024/2025 revenue totalled €470.2 million (with nine-month revenue at €1,235.4 million), compared with €421.0 million in Q3 2023/2024 (and €1,199.6 million over nine months of the previous year). The Group comments on its revenue and the associated financial indicators in compliance with its operational reporting (see "Economic revenue" below), which is more representative of its business, i.e. (i) with the presentation of joint undertakings in proportional consolidation, and (ii) excluding the impact of IFRS16: € millions 9 months 2024/2025 9 months 2023/2024 Change IFRS revenue 1,235.4 1,199.6 +3.0% Proportional integration of joint-ventures +46.4 +51.0 -9.0% Integration of lease operations +12.0 +18.2 -34.2% Economic revenue (Operational reporting) 1,293.8 1,268.9 +2.0% Revenue is also presented according to the following operational sectors4: - Center Parcs covering operation of the domains marketed under the Center Parcs, Sunparks and Villages Nature brands, and the building/renovation activities for tourism assets.- Pierre & Vacances covering the tourism businesses operated in France and Spain under the Pierre & Vacances brand and the Asset Management business line5.- a distribution and services platform, operating the Campings maeva, maeva Home, La France du Nord au Sud and Vacansoleil.- Adagio, covering operation of the city residences leased by the Group and entrusted to the Adagio SAS joint venture under management mandates, as well as operation of the sites directly leased by the joint venture.- An operating segment covering the Major Projects6 and Senioriales7 business lines.- the Corporate operational segment housing primarily the holding company activities. A reconciliation table presenting economic revenue and revenue under IFRS accounting is presented by operational sector at the end of the press release.Q3 Total 9 months Economic revenue, €m 2024/25 2023/24 Change excl. calendar effect* 2024/25 2023/24 Change Center Parcs 312.4 283.2 +10.3% 796.3 778.1 +2.3% Tourism 306.1 273.1 +12.1% 770.8 752.1 +2.5% Accommodation revenue 235.5 209.5 +12.4% +5.2% 592.8 581.7 +1.9% Supplementary income 70.7 63.6 +11.1% 178.1 170.5 +4.5% Others 6.3 10.1 -37.8% 25.4 26.0 -2.2% Pierre & Vacances 85.3 78.1 +9.2% 248.0 236.9 +4.7% Accommodation revenue 65.0 60.0 +8.4% +6.5% 198.7 190.4 +4.3% Supplementary income 20.2 18.1 +12.0% 49.4 46.4 +6.4% Adagio 68.6 59.1 +16.0% 172.5 164.9 +4.6% Accommodation revenue 61.8 53.2 +16.2% +15.4% 154.4 147.9 +4.4% Supplementary income 6.9 6.0 +14.7% 18.0 17.1 +5.8% 12.6 10.9 +15.6% 41.5 34.8 +19.3% Supplementary income 12.6 10.9 +15.6% 41.5 34.8 +19.3% Major Projects & Senioriales 12.3 15.4 -20.2% 34.4 53.6 -35.9% Corporate 0.5 0.0 NA 1.1 0.6 +98.6% TOTAL GROUP 491.6 446.6 +10.1% 1,293.8 1,268.9 +2.0% Economic revenue - Tourism 472.6 421.2 +12.2% 1,232.9 1,188.7 +3.7% Accommodation revenue 362.2 322.6 +12.3% +7.1% 945.9 920.0 +2.8% Supplementary income 110.4 98.5 +12.0% 287.0 268.7 +6.8% Economic revenue - Others 19.0 25.4 -25.2% 60.9 80.1 -24.0% * estimated impact on accommodation revenue of spring school holidays and Easter weekend falling in April 2025 vs. March 2024. Economic revenue - Tourism Revenue from the tourism businesses rose by 12.2% in the third quarter of the year, with substantial growth across all brands, partly underpinned by a beneficial calendar effect (certain holiday periods shifted from Q2 into Q3 this year). After neutralising this shift in revenue, the rise in the Group's Q3 accommodation revenue remained robust, with an estimated performance of +7.1%. Supplementary income8 also increased (+12.0%), driven by both higher on-site sales (+12.6%) and momentum in business at (+15.6%). Over the first nine months of the year, revenue from the Group's brands was up 3.7% to €1,232.9 million. The customer satisfaction rate continued to rise across all brands with the NPS9 over the past 12 months up 9.0 points for maeva, 6.0 points for Center Parcs, 5.1 points for Pierre & Vacances and 0.4 points for Adagio. Accommodation revenue Accommodation revenue totalled €362.2 million in Q3 2024/2025, up 12.3% relative to the year-earlier period (+7.1% after neutralising the calendar effect due to a shift in holiday periods from Q2 to Q3). This growth was driven by both a rise in average letting rates (+6.5%) and the occupancy rate (+2.5 points). Change in key operational performance indicators RevPar Average letting rates (by night, for accommodation) Number of nights sold Occupancy rate € (excl. tax) Chg. % N-1 € (excl. tax) Chg. % N-1 Units Chg. % N-1 % Chg. Pts N-1 Center Parcs 146.3 +9.3% 188.3 +7.9% 1,250 341 +4.2% 77.7% +1.0 pt Pierre & Vacances 60.3 +8.2% 93.9 +4.6% 692,560 +3.6% 70.4% +1.7 pts Adagio 95.4 +15.4% 121.9 +4.3% 506,580 +11.4% 78.4% +7.1 pts Total Q3 2024/2025 revenue 108.6 +10.6% 147.9 +6.5% 2,449 481 +5.4% 75.5% +2.5 pts Center Parcs 125.0 +1.6% 176.4 +4.6% 3,360 143 -2.6% 70.9% -2.1 pts Pierre & Vacances 72.6 +3.0% 119.6 +2.7% 1,661 616 +1.6% 67.7% -0.3 pt Adagio 80.1 +5.6% 108.7 +0.9% 1,420 641 +3.5% 74.2% +3.2 pts Total 9M 2024/2025 revenue 100.6 +2.5% 146.8 +3.0% 6,442 400 -0.2% 70.6% -0.5 pt Change in accommodation revenue by brand Revenue increased across all brands during Q3: - Center Parcs: +12.4% (+5.2% after neutralising the shift in revenue)Growth was driven by average letting rates (+7.9%) reflecting the premiumisation of the offer, and the number of nights sold (+4.2%), benefiting both: - the French domains (+21.8%), with solid performances especially from the 108 new VIP cottages opened as part of the extension of the Villages Nature Paris domain in early May 2025.- the domains located in BNG10 (+8.0%, o/w +11.5% in the Netherlands, +5.5% in Germany and +5.2% in Belgium). The occupancy rate increased by 1 points to 77.7% over the period. - Pierre & Vacances: +8.4% (+6.5% after neutralising the shift in revenue)Growth in revenue was driven by the rise in average letting rates (+4.6%) and the number of nights sold (+3.6%).- Revenue generated by the residences in France (+4.0%) was driven by the hike in business at mountain destinations, which posted occupancy rates of more than 80% over the quarter and average letting rates up almost 9%. Revenue from seaside destinations (both metropolitan France and the French West Indies) was down slightly in view of the reduction11 in the stock operated by lease (-0.9% of nights offered relative to Q3 of the previous year).- Revenue from residences in Spain surged 18.4%, driven by a price effect (+11.8%) and a volume effect (+5.9% of nights sold). The occupancy rate was up by 1.7 points to 70.4% over the period. - Adagio: +16.2% (+15.4% after neutralising the shift in revenue)Third-quarter growth was underpinned by both:- France (+17.8%), with particularly dynamic business in the Ile de France region (occupancy rate of almost 80% over the quarter). Note that Q3 of the previous year was penalised by the trend to avoid the Paris region in the run-up to the Paris 2024 Olympic Games.- Other countries where the brand is operated (+9.7%), notably with the opening of an aparthotel in London (London City East) on 1 June 2025. In all, over the first nine months of the year, accommodation revenue totalled €945.9 million, up 2.8% relative to the year-earlier period. Supplementary income12 Q3 supplementary income totalled €110.4 million, up 12.0% relative to the year-earlier period, driven by: - maeva, which confirmed its growth in the third quarter (+15.6%) in view of the European development of its distribution platform through the Vacansoleil platform which represented a third of the quarter's performance.- growth in on-site sales (+12.6%, of which +8.8% for revenue related to catering and +17.4% for animation businesses). Over the first nine months of the year, supplementary income totalled €287 million, up 6.8%. Economic revenue - Others Q3 2024/2025 revenue from other business totalled €19.0 million compared with €25.4 million in Q3 2023/2024 (decline with no significant impact on EBITDA and confirming the Group's ongoing withdrawal from property and non-strategic businesses). Revenue from other businesses was primarily made up of: - renovation operations at Center Parcs domains on behalf of owner-lessors, for €6.3 million (mainly for the extension of the Park Eifel Domain in Germany and renovation of the Domaine des Hauts de Bruyères in France) compared with €10.1 million in Q3 2023/2024.- les Senioriales for €3.9 million (vs. €7.1 million in Q3 2023/2024).- the Major Projects business line for €8.4 million, primarily for the extension of the Villages Nature Paris Domain, compared with €8.3 million in Q3 2023/2024. In all, over the first nine months of the year, revenue from other business totalled €60.9 million, down 24.0% relative to the year-earlier period. 2] Outlook - Tourism businesses In view of the level of reservations to date for the summer season (representing 80% of the target or an achievement rate similar to the year-earlier level), as well as momentum in last-minute bookings, the Group is forecasting an increase in accommodation revenue over the summer period compared with the previous year. On the strength of its previous performances and these revenue prospects, the Group confirms its guidance for full-year 2024/2025 EBITDA of more than €180 million (vs. €163 million in 2023/2024, excluding the impact of non-recurring income). 3] Financial calendar Full-year revenue for 2024/2025 will be published on 23 October 2025 after the market close. 4] Reconciliation table between economic revenue and revenue under IFRS Under IFRS accounting, revenue for the first nine months of 2024/2025 totalled €1,235.4 million, compared with €1,199.6 million in the year-earlier period, representing growth of 3% driven by the tourism businesses (primarily driven by growth in average letting rates). € millions 2024/2025 Economic revenue according to operational reporting Restatement IFRS11 Impact IFRS16 2024/2025 IFRS revenue Center Parcs 796.3 - -5.4 790.8 Pierre & Vacances 248.0 +0.1 - 248.1 Adagio 172.5 -43.4 - 129.1 41.5 - - 41.5 Major Projects & Senioriales 34.4 -3.5 -6.6 24.3 Corporate 1.1 +0.4 - 1.5 Total 9M 2024/2025 revenue 1,293.8 -46.4 -12.0 1,235.4 € millions 2023/2024 Economic revenue according to operational reporting Restatement IFRS11 Impact IFRS16 2023/2024 IFRS revenue Center Parcs 778.1 - -9.8 768.4 Pierre & Vacances 236.8 +0.1 - 236.9 Adagio 164.9 -41.1 - 123.8 34.8 - - 34.8 Major Projects & Senioriales 53.6 -9.9 -8.5 35.2 Corporate 0.6 - - 0.6 Total 9M 2023/2024 revenue 1,268.9 -51.0 -18.2 1,199.6 IFRS11 adjustments: for its operational reporting, the Group continues to integrate joint operations under the proportional integration method, considering that this presentation is a better reflection of its performance. In contrast, joint ventures are consolidated under equity associates in the consolidated IFRS accounts. Impact of IFRS16: The application of IFRS16 leads to the cancellation in the financial statements of a share of revenue and capital gains generated on disposals made under the framework of property operations with third-parties (given the Group's right-of-use lease contracts). 1 Guidance announced in the Press Release of 28 May 20252Adjusted EBITDA = current operating profit stemming from operational reporting (consolidated operating income before other non-current operating income and expense, excluding the impact of IFRS 11 and IFRS 16 accounting rules) adjusted for provisions and depreciation and amortisation of fixed operating assets. Adjusted EBITDA includes the benefit of rental savings made by the Villages Nature project as a result of the agreements signed in December 2022 (€10.9m in FY 2023, €14.5m in FY 2024, €12.4m in FY 2025 and €4.0m in FY 2026).3 Recognition in the first half of the 2023/2024 financial year of additional German government aid of €10.9 million for the Covid-19 pandemic.4 Operational sectors defined in compliance with the IFRS 8 standard. See page 184 of the Universal Registration Document, filed with the AMF on 23 December 2024 and available on the Group's website: 5 Notably in charge of relations with individual and institutional lessors6 Business line responsible for the construction and completion of new assets for the Group in France7 Subsidiary specialised in property development and operating of non-medicalised residences (managed by mandate since the disposal on 1 January 2024 of the lease businesses to ACAPACE)8 Revenue from on-site activities (catering, animation, stores, services etc.), co-ownership and multi-owner fees and management mandates, marketing margins and revenue generated by the business line.9 Net Promoter Score10 Belgium, the Netherlands, Germany11 Decline in stock due to non-renewal of leases and withdrawal from loss-making sites12 Revenue from on-site activities (catering, animation, stores, services etc.), co-ownership and multi-owner fees and management mandates, marketing margins and revenue generated by the business line. View source version on Contacts For further information: M&A, Investor Relations and Strategic Operations Emeline Lauté+33 (0) 1 58 21 54 Press Relations Valérie Lauthier+33 (0) 1 58 21 54 Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Hitachi Rail, SYMCA partner on Supertram modernisation initiative
Hitachi Rail, SYMCA partner on Supertram modernisation initiative

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Hitachi Rail, SYMCA partner on Supertram modernisation initiative

Hitachi Rail has entered into a 15-year technology partner framework agreement with the South Yorkshire Mayoral Combined Authority (SYMCA) to advance the South Yorkshire Supertram network in the UK. This agreement designates Hitachi Rail as the strategic technology partner for SYMCA, focusing on modernising the light rail infrastructure in the region. The initiative is part of SYMCA's strategy to enhance public transport services, improve connectivity among communities, and contribute to economic growth in South Yorkshire. SYMCA Transport Development and Capital Delivery director Tom Howard said: 'This strategic partnership with Hitachi will ensure we can work collaboratively to harness the latest technology from an internationally experienced supplier in the Light Rail sector, delivering real benefits for our passengers over the lifetime of the framework. 'We look forward to starting work together, which over the first couple of years will initially focus on systems to improve the reliability of timetable delivery alongside enhanced real-time information, making journeys smoother and more predictable for passengers.' The framework will enable Hitachi Rail to implement modern, digitally driven solutions that aim to improve both operational efficiency and the passenger experience on the Supertram system. This partnership is aligned with SYMCA's objective to develop a comprehensive public transport network that promotes sustainability. Hitachi Rail, which employs over 200 staff in Doncaster, is expected to generate additional local employment opportunities and foster skills development and supply chain involvement in the North of England, through the new agreement. Hitachi Rail UK GTS managing director and vice president Andy Bell said: 'This 15-year partnership represents more than a contract, it's a long-term commitment to South Yorkshire. 'We're bringing together our globally proven technologies, transformational delivery expertise, and local presence in the South Yorkshire region to help deliver a stronger, smarter Supertram network for the future.' In June, Hitachi Rail won a contract from Kolin Insaat Turizm Sanayi Ve Ticaret to design, supply, and oversee the installation of signalling systems at Kapıkule Station in Türkiye. The contract covers the conventional line sections from Edirne West to Kapıkule East and from Kapıkule East to Kapıkule West. "Hitachi Rail, SYMCA partner on Supertram modernisation initiative" was originally created and published by Railway Technology, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site. Sign in to access your portfolio

LVMH sales weaker than expected as luxury sector awaits US trade deal
LVMH sales weaker than expected as luxury sector awaits US trade deal

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LVMH sales weaker than expected as luxury sector awaits US trade deal

PARIS -Luxury bellwether LVMH reported a slightly worse than expected 4% decline in quarterly sales on Thursday, though CFO Cecile Cabanis expressed confidence for the rest of the year. Sales for the second quarter to the end of June fell 4% to 19.5 billion euros ($22.96 billion) compared with a consensus forecast for a 3% decline compiled by Visible Alpha, cited by UBS. Sales at the group's fashion and leather division, accounting for the bulk of profits, were down 9% amid a deepening gloom in the industry, below expectations for a 6% drop. Chief Financial Officer Cabanis said on a call with reporters that she was still "rather confident" about the rest of the year as the group expected trade talks between the EU and the Trump administration to deliver good news soon. Asked how LVMH would view a potential general tariff rate of 15% anticipated for exports to the United States, Cabanis said that would be an "overall good outcome for the general mood of our clients". With the exception of wines and spirits, where customers are much more resistant to price rises, Cabanis said LVMH's brands, which include Louis Vuitton, Dior and Bulgari could draw on their pricing power to mitigate the tariff impact. ($1 = 0.8493 euros) Sign in to access your portfolio

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