Sanofi Shares Fall on Mixed Lung Disease Drug Results
Sanofi 's shares fell following mixed results of its experimental drug for a deadly lung condition.
Itepekimab, a medicine that is being jointly developed by Sanofi and Regeneron, is being tested as a treatment for chronic obstructive pulmonary disease in former smokers. Two late stage trials showed contrasting results, Sanofi said Friday, with one showing a reduction in worsening of the condition — called exacerbations — of 27%. The other trial didn't show the same benefit despite having shown it earlier in the study.
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Hamilton Spectator
2 hours ago
- Hamilton Spectator
England star Millie Bright pulls out of selection for Women's Euros for health reasons
England defender Millie Bright withdrew herself from selection for the European Championship on Wednesday because of health reasons. 'Right now I'm not able to give 100% mentally or physically,' Bright wrote in a post on Instagram . The absence of the 31-year-old Bright — a long-time, first-choice center back for her country — is another blow to England coach Sarina Wiegman, who saw experienced goalkeeper Mary Earps announce her retirement from international soccer last week. On Tuesday, another stalwart of the England team — midfielder Fran Kirby — also retired from national team duty. Bright made herself unavailable for the recent England camp featuring games against Portugal and Spain and later said on a podcast: 'Mentally and physically I'm at my limits.' Wiegman said after the 2-1 loss to Spain on Tuesday that she would have a conversation with Bright about her availability for the Euros in Switzerland next month, where England will be defending its title from 2022. The following afternoon, Bright used social media to announce she would not be taking part in the Euros. She described it as 'one of the hardest decisions I've ever had to make' and said it came after 'careful thought and discussions with the team.' 'Football has given me so much, and representing my country has always been my greatest honor,' said Bright, who has made 88 appearances for England and played in the team that won the Euros in 2022 before captaining the side on its run to the World Cup final in 2023. 'My pride and ego tells me to go but I think the team and the fans deserve more.' She said as stepping back from the team 'is the right thing for my health, my future in the game and most importantly the team.' 'It wouldn't be fair,' she said, 'for me to take the place and opportunity away from another player who is ready and able to give everything for the badge and country.' Bright has just helped Chelsea to win the Women's Super League-FA Cup-League Cup treble in the recently completed domestic season. Turbulent week for Wiegman England's squad will be shorn of experience in Switzerland, with confirmation of Bright's absence coming soon after the international retirements of Earps and Kirby – two other members of the Euro 2022-winning team. Earps, a colorful and charismatic presence in the squad, played 53 games for her country but had lost her place in the team to Chelsea's Hannah Hampton. Kirby announced to her England teammates in the locker room after the loss to Spain that she was retiring from internationals. She played 77 games and had been told by Wiegman that she wasn't going to be selected for the Euros. Wiegman will name her final squad for the Euros on Thursday. England's first game of its title defense is against France on July 5. ___ AP soccer:
News24
3 hours ago
- News24
Greenpeace returns Macron waxwork stolen in 'radioactive' protest
Greenpeace activists have returned a wax figure of President Emmanuel Macron they had stolen from a Paris museum. The move was part of a protest to urge Macron to end nuclear cooperation between France and Russia. After taking the waxwork from the Grevin Museum on Monday, the campaigners had placed it outside the Russian embassy in a symbolic protest. For climate change news and analysis, go to News24 Climate Future. Greenpeace activists have returned a wax figure of President Emmanuel Macron they had stolen from a Paris museum, staging a new stunt to protest against continuing "radioactive" ties between France and Russia despite the invasion of Ukraine. The campaign group said the stunt involving the French head of state's waxwork doppelganger had the serious message of urging the real Macron to stop all economic cooperation with Russia, especially in nuclear energy. After taking the waxwork from the Grevin Museum in a carefully planned heist on Monday, the campaigners had placed it outside the Russian embassy in a symbolic protest. Carrying on the action late on Tuesday, they placed the waxwork, estimated to be worth 40 000 euros ($45 500), in a chest and put it outside the headquarters of French electricity giant EDF. They also stood the statue on its feet and put next to it a sign with a slogan denouncing Macron for not cutting ties with Russia under Vladimir Putin, in particular in nuclear energy. "Putin-Macron radioactive allies," the sign said. Police then arrived and secured the chest and waxwork ahead of its return to the Grevin Museum, the Paris equivalent of Madame Tussauds in London. READ | EU climate investments lagging 'well below' target - report Just borrowed "We came to bring back the statue of Emmanuel Macron because, as we said from the start, we had just borrowed it," Jean-Francois Julliard, executive director of Greenpeace France, told AFP at the scene. "We notified both the management of the Grevin Museum and the police. It's up to them to come and retrieve it," he said. The choice of the EDF headquarters was "to make Macron face up to his responsibilities concerning the trade that is maintained with Russia, particularly in the nuclear sector," he added. According to Julliard, French companies can still, despite the sanctions regime in place since the invasion, "import a whole host of products from Russia" including enriched uranium to power French nuclear power plants, natural uranium transiting through Kazakhstan and Uzbekistan via Russia, LNG and chemical fertilisers. He said Greenpeace particularly criticised the surge in Russian fertiliser imports into the EU, which rose some 80% between 2021 and 2023 according to French fertiliser manufacturers. EDF is notably tied to a 600-euro-million contract signed in 2018 with Tenex, a subsidiary of the Russian nuclear giant Rosatom, for the recycling of EDF's reprocessed uranium. Feeding the war machine "France publicly supports Ukraine, but behind the scenes, contracts with Russia continue," Greenpeace France said in a statement on its Instagram account, accusing Paris of "feeding the Russian war machine". Without giving details, it said a Russian cargo ship transporting uranium "will dock again" in the northern port of Dunkirk on Thursday in what the group described as the latest scene from a "well organised ballet". It said in 2024 a quarter of the enriched uranium imported into France came from Russia, and half of the natural uranium imported into France came from Kazakhstan and Uzbekistan, the majority of which transits via Rosatom on Russian soil. According to a police source, two women and a man on Monday entered the Grevin Museum posing as tourists and, once inside, changed their clothes to pass for workers. The activists slipped out through an emergency exit with the waxwork. A museum spokeswoman acknowledged that "they had clearly done their research very thoroughly". She said the activists distracted a security guard by asking a question about a disabled access lift, while some of them donned maintenance coats. With the stunt involving his double, Greenpeace said it was up to Macron to act. "We call on the real head of state to stop this double talk and immediately sever these toxic ties with Russia," it said.
Forbes
4 hours ago
- Forbes
How Income Can Affect Your Health And Population Health
Los Angeles, CA - September 21: Hundreds of needy people line up around the block to receive food ... More from embattled 14th District Los Angeles City Council member Kevin de León, during a free food distribution. (Allen J. Schaben / Los Angeles Times via Getty Images) Low-income individuals that received regular monthly cash stipends visited the emergency department less, had fewer hospital admissions and participated in more outpatient subspecialty care according to an article in the Journal of the American Medical Association. The authors of the study looked at nearly 2900 low-income individuals who applied for a lottery in Chelsea, Massachusetts. Of those individuals, about 1750 of them received $400 per month for a nine month period. The individuals that received money had 27% fewer emergency room visits compared to those that did not receive the monthly payments. The aforementioned study underscores the powerful role socioeconomic status plays in shaping health outcomes across populations. So how exactly can income affect health? Below are some of the most important ways money can influence health and its related outcomes. Higher income generally translates to better quality healthcare services. Individuals with more money are more likely to have health insurance, which allows them to afford hospital visits, prescription drugs and preventive interventions. Conversely, those with lower incomes may be hesitant to receive healthcare they need because it is too expensive, leading to untreated illnesses that could be managed or even cured with early intervention. In 2022, nearly 26 million nonelderly Americans were uninsured according to Kaiser Family Foundation. Nearly 2 in 3 (64%) of nonelderly Americans who were uninsured said they were because the cost of healthcare insurance was too high. As an example, consider a low-dose CT scan of the chest that is done to screen for lung cancer. The out-of-pocket cost for the study is typically around $300, and insurance coverage for it is variable. Nearly half (44%) of lung cancers are caught at a late stage, with survival rates falling to just 7% according to the American Lung Association. With lung cancer being the deadliest cancer of all cancers, those with less income are less likely to be screened and less likely to find lung cancer at a stage where it is treatable and curable. Living environments are another critical determinant of health outcomes influenced by income. Wealthier individuals can afford housing in neighborhoods with lower crime rates, better schools and facilities such as gyms and parks that contribute to superior physical and mental health. Low-income individuals, on the other hand, may live in poor neighborhoods and may be exposed to environmental hazards like mold and air pollution. Consider asthma, an obstructive lung disease that causes coughing, wheezing and chest tightness. Many allergens can trigger asthma, which include but are not limited to dust, mold and air pollution. Thus, those that live in poorer neighborhoods and are constantly exposed to these environmental hazards are more likely to develop asthma, which can be life-threatening if not treated appropriately. One's income can also have a profound effect on determining the quality and quantity of food one can afford. Higher-income households have the luxury of greater access to more nutritious food, while lower-income families may have to purchase cheaper, less healthy and processed foods out of necessity. Healthier foods cost nearly twice as much as unhealthier foods on average per serving, according to research from the International Journal of Environmental Research and Public Health. Cheaper processed foods are usually higher in sugars, fats and salts. These types of foods contribute to poor nutrition and chronic diseases such as diabetes, heart disease and obesity. Financial stability can also contribute to mental well-being. For example, those that live in poverty have to worry about their next meal and whether or not they will have food to eat. These worries can lead to a high level of anxiety and even depression, which can detrimentally affect mental health. It is of no surprise that those with the lowest incomes in a community suffer 1.5 to 3 times more frequently from anxiety, depression and other mental health illnesses compared to those with the highest incomes. What can be done to alleviate the obvious and profound health disparities caused by income inequality? The obvious answer is expanding access to healthcare insurance for all populations. Currently, 44 million Americans are enrolled in healthcare coverage through the Affordable Care Act according to KFF News. In addition, there must be a concerted effort by lawmakers and community activists to invest in safe and affordable housing, improve the availability of nutritious foods in low-income neighborhoods and expand important healthcare services such as preventive screening studies in an effort to decrease cancer in impoverished areas throughout the U.S. Income and health are inextricably related, and so much work needs to be done in America to address health inequities caused by income inequality.
