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Carolyn Hax: At yo-yo's end with supporting friend through cyclic breakups

Carolyn Hax: At yo-yo's end with supporting friend through cyclic breakups

Washington Post31-05-2025
Adapted from an online discussion.
Dear Carolyn: I am probably at this point overinvested here, but my really good friend has been in a terrible relationship for eight years now: They break up, friend dumps on me, there's a few good months, they get back together, friend distances from friends, they break up again, etc.
They just broke up again. I am dreading the process but feel like not being there would be problematic for my social life. I am just done with the drama and feel like saying so.
Anyway, can you help me understand why otherwise great people do this yo-yo thing?
— Yo-yo's Friend
Yo-yo's Friend: Not fixing a near-decade problem mystifies me, too, so I'm not sure I can help you understand. You would think they'd tire of it. Or maybe we're both missing the point — maybe they include the on-and-off as part of the whole.
It must satisfy a need for both of them, or else they'd stay apart one of these times. An unhealthy need, or else they'd stay together. So — two unhealthy needs they use each other to avoid fixing. How's that.
As for what to say to your friend this time, now that you're 'done with the drama' and possibly a little salty, I think eight years of getting dumped on gives you standing to speak your mind.
You wrote a fine start: 'I am probably at this point overinvested, but you have been in an unstable relationship for eight years now. You break up, dump on me, have a few good months, get back together, distance yourself from friends, break up again, etc.'
Then maybe just: 'I don't know what to say anymore. But acting like this is normal or okay doesn't seem like the right call. Is there anything else I can do here?'
Like I said, though — this may be their normal. They may be life partners, in their yo-yo way. As designated friend, it might help you to see it this way: to assume there is no 'process' to 'dread' because there is no off or on, it is all of a piece, and to divest from the drama and expect nothing besides seeing your friend when your friend is available.
And don't try to fix anything — just be 'sorry to hear that.'
Dear Carolyn: I live in the East and work full time even though I am past retirement age; I like to work, I'm good at my job and it gives me something to do. I have lots of friends and plan lunches and classes weekly.
Some of my grandchildren live in the West, and I feel guilty that I don't move there to take care of them, especially 9-year-old twins. Both parents work round-the-clock, and they rely on the older kids to take care of the twins.
I don't want to move where they live. However, I feel like I'm being selfish, and they could really use my help; they need someone to pick up the kids from school, prepare dinner, help with homework — a housekeeper. Should that be my job?
— Grandparent
Grandparent: 'Should' you, no, not if you don't want to and you're deeply rooted.
It's alarming that older kids are being pressed into parent duty for youngers, if they're more than just helping out. But it doesn't make sense to me that your cross-country relocation, maybe effectively for good, is the only solution for at most a six- or seven-year problem.
Can you afford to help them hire steady after-school child care? Then you stay above your social safety net, which is so important, and they get responsible relief.
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Consistently finding lower lithium levels in the brains of people with memory loss amounted to a smoking gun, Yankner said. 'At first, frankly, we were skeptical of the result because it wasn't expected,' said Yankner. But it held up even when they checked samples from other brain banks at Massachusetts General Hospital, Duke and Washington universities. 'We wanted to know whether this drop in lithium was biologically meaningful, so we devised an experimental protocol where we could take lithium selectively out of the diet of mice and see what happens,' Yankner said. When they fed the mice a low-lithium diet, simply dropping their natural levels by 50%, their brains rapidly developed features of Alzheimer's. 'The neurons started to degenerate. The immune cells in the brain went wild in terms of increased inflammation and worse maintenance function of the neurons around them, and it looked more like an advanced Alzheimer patient,' Yankner said. The team also found the gene expression profiles of lithium-deficient mice and people who had Alzheimer's disease looked very similar. The researchers then started to look at how this drop in lithium might occur. Yankner said in the earliest stages there's a decrease in the uptake of lithium in the brain from the blood. They don't yet know exactly how or why it happens, but it's likely to be from a variety of things including reduced dietary intake, as well as genetic and environmental factors. The major source of lithium for most people is their diet. Some of the foods that have the most lithium are leafy green vegetables, nuts, legumes and some spices like turmeric and cumin. Some mineral waters are also rich sources. In other words, Yankner said, a lot of the foods that have already proven to be healthy and reduce a person's risk of dementia may be beneficial because of their lithium content. 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Scientists say it may be possible to protect aging brains from Alzheimer's with an old remedy — lithium
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CNN

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Scientists say it may be possible to protect aging brains from Alzheimer's with an old remedy — lithium

Chronic diseases Dementia Getting olderFacebookTweetLink Follow In a major new finding almost a decade in the making, researchers at Harvard Medical School say they've found a key that may unlock many of the mysteries of Alzheimer's disease and brain aging — the humble metal lithium. Lithium is best known to medicine as a mood stabilizer given to people who have bipolar disorder and depression. It was approved by the US Food and Drug Administration in 1970, but it was used by doctors to treat mood disorders for nearly a century beforehand. Now, for the first time, researchers have shown that lithium is naturally present in the body in tiny amounts and that cells require it to function normally — much like vitamin C or iron. It also appears to play a critical role in maintaining brain health. 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The research provides a unifying theory that helps explain so many of the puzzle pieces scientists have been trying to fit together for decades. 'It is a potential candidate for a common mechanism leading to the multisystem degeneration of the brain that precedes dementia,' said Dr. Bruce Yankner, a professor of genetics at Harvard Medical School, who led the study. 'It will take a lot more science to determine whether this is a common pathway… or one of several pathways,' to Alzheimer's, he added. 'The data are very intriguing.' In an editorial published in Nature, Dr. Ashley Bush, a neuroscientist who directs the Melbourne Dementia Research Center at the University of Melbourne in Australia, said the researchers 'present compelling evidence that lithium does in fact have a physiological role and that normal aging might impair the regulation of lithium levels in the brain.' He was not involved in the study. 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He and his colleagues tested different lithium compounds and found one — lithium orotate — that doesn't bind to amyloid beta. When they gave lithium orotate to mice with signs of Alzheimer's in their brains, these changes reversed: Beta amyloid plaques and tangles of tau that were choking the memory centers of the brain were reduced. Mice treated with lithium were once again able to navigate mazes and learn to identify new objects, whereas those who got placebos showed no change in their memory and thinking deficits. In its natural form, lithium is an element, a soft, silvery-white metal that readily combines with other elements to form compounds and salts. It's naturally present in the environment, including in food and water. Scientists have never fully known how it works to improve mood — only that it does. The original formula for 7Up soda included lithium — it was called 7Up Lithiated Lemon Soda — and touted as a hangover cure and mood lifter 'for hospital or home use.' 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Neither he nor any of his co-authors have a financial interest in the outcome of the research, he said. The National Institutes of Health was the major funder of the study, along with grants from private foundations. 'NIH support was absolutely critical for this work,' Yankner said. The new research corroborates earlier studies hinting that lithium might be important for Alzheimer's. A large Danish study published in 2017 found people with higher levels of lithium in their drinking water were less likely to be diagnosed with dementia compared with those whose tap water contained naturally lower lithium levels. Another large study published in 2022 from the United Kingdom found that people prescribed lithium were about half as likely has those in a control group to be diagnosed with Alzheimer's, suggesting a protective effect of the drug. But lithium's use in psychiatry caused it to become type cast as therapeutic, Yankner said. No one realized it might be important to the body's normal physiology. That happened in part because the amounts of lithium that typically circulate in the body are so small, they couldn't be quantified until recently. Yankner and his team had to adapt new technology to measure it. In the first stage of the research, the scientists tested the brain tissue and blood of older patients collected by the brain bank at Rush University for trace levels of 27 metals. Some of the patients had no history of memory trouble, while others had early memory decline and pronounced Alzheimer's. While there was no change in the levels of most metals they measured, lithium was an exception. Lithium levels were consistently lower in patients with mild cognitive impairment or Alzheimer's compared to those with normal brain function. The brains of patients Alzheimer's disease also showed increased levels of zinc and decreased levels of copper, something scientists had observed before. Consistently finding lower lithium levels in the brains of people with memory loss amounted to a smoking gun, Yankner said. 'At first, frankly, we were skeptical of the result because it wasn't expected,' said Yankner. But it held up even when they checked samples from other brain banks at Massachusetts General Hospital, Duke and Washington universities. 'We wanted to know whether this drop in lithium was biologically meaningful, so we devised an experimental protocol where we could take lithium selectively out of the diet of mice and see what happens,' Yankner said. When they fed the mice a low-lithium diet, simply dropping their natural levels by 50%, their brains rapidly developed features of Alzheimer's. 'The neurons started to degenerate. The immune cells in the brain went wild in terms of increased inflammation and worse maintenance function of the neurons around them, and it looked more like an advanced Alzheimer patient,' Yankner said. 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'You know, oftentimes one finds in science that things may have an effect, and you think you know exactly why, but then subsequently turn out to be completely wrong about why,' he said.

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