Bryan Johnson's latest anti-ageing experiment turns his urine blue; know his million-dollar health routine that aims to help him live forever
, the tech entrepreneur best known for spending millions annually to slow his ageing process, is once again in the spotlight. The 47-year-old millionaire recently revealed that his latest biohacking experiment taking methylene blue has turned his urine bright blue.
Johnson shared the update with his followers on X (formerly Twitter), writing: 'My urine is now blue.'
While the comment might sound tongue-in-cheek, Johnson is entirely serious. Methylene blue is a legitimate, FDA-approved compound with a long history in medicine and now, a rising trend in the biohacking community.
Bryan Johnson's new anti-ageing experiment
: What is it and is it trending
Methylene blue (MB), or methylthioninium chloride, is a cobalt-coloured synthetic dye originally used in the textile industry.
In the late 1800s, it was repurposed as a medical treatment—first for malaria, and later for a rare blood condition called methemoglobinemia, where red blood cells can't transport oxygen effectively.
Today, the FDA approves methylene blue for:
Treating blood disorders like methemoglobinemia
Managing cyanide poisoning
Supporting certain neurological conditions
However, in the biohacking and anti-ageing community, methylene blue is gaining traction for something else: its potential to enhance mitochondrial function. Mitochondria, often dubbed the 'powerhouses of the cell,' play a key role in energy production and cellular health.
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Enthusiasts believe that by improving mitochondrial performance, methylene blue might boost memory, slow ageing, and improve physical stamina.
'Like I'm in Avatar': Bryan Johnson's extreme biohacking lifestyle
If methylene blue seems like an odd addition, it's worth noting that Johnson's wellness regimen is anything but ordinary. The Blueprint project, Johnson's full-time longevity protocol, involves:
A 100+ supplement stack
Precision-controlled sleep, diet, and exercise
Plasma infusions (including from his teenage son)
Experimental therapies, tracked with over 50 biological markers
His latest addition of methylene blue, is just one of many. Johnson claims he's already experiencing vivid results, joking that he now feels 'like I'm in Avatar.' It's a surreal visual, but for him, it signals that the compound is taking effect. According to Johnson, his biological metrics are already outperforming his age:
Heart health comparable to a 37-year-old
Lung capacity similar to an 18-year-old
Skin elasticity more like that of a 10-year-old
Is methylene blue safe for anti-ageing use
While the biohacking community may be buzzing about methylene blue, medical professionals are urging caution.
Though methylene blue is FDA-approved for specific conditions, using it as a nootropic or anti-ageing therapy is still highly experimental.
Potential risks and side effects include:
Serotonin syndrome: dangerous when combined with antidepressants
Blood disorders: unsafe for individuals with G6PD deficiency
Kidney risks: should be avoided by those with renal issues
Pregnancy risks: not recommended during pregnancy
Allergic reactions: known sensitivities can trigger severe symptoms
According to Harvard Health Publishing, the research on methylene blue's longevity benefits remains limited and inconclusive. While early animal studies and some human trials suggest potential cognitive and metabolic improvements, clinical evidence is not yet strong enough to support widespread use.
Bryan Johnson's biohacking journey
continues: From methylene blue to IHHT therapy
Methylene blue is far from the only new therapy in Johnson's pipeline. Just before revealing his blue-tinged biohack, he began IHHT (Intermittent Hypoxia-Hyperoxia Training)—a therapy that alternates between oxygen deprivation and saturation via a breathing mask.
IHHT is claimed to:
Improve cardiovascular health
Boost brain function
Stimulate mitochondrial resilience
Potentially slow signs of ageing
Clinics across Europe and the US are now offering IHHT to clients interested in peak performance and anti-ageing benefits. However, like most interventions in the longevity field, IHHT is still experimental, and long-term research is lacking.
Also Read | Did The Simpsons really predict Donald Trump's death in August 2025? Viral video sparks major debate online
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