The best PDRN skincare products to shop right now

Vogue Singapore

11-08-2025

PDRN—or more accurately, polydeoxyribonucleotide. It's the superstar ingredient that's taken the skincare world by storm, thanks to its impressive ability to rejuvenate the complexion. Derived from salmon DNA, the K-beauty staple is widely lauded for enhancing skin elasticity, boosting the production of collagen, and improving overall skin texture.
While it's been increasingly incorporated into various aesthetic treatments, it's also blessedly easy to harness the ingredient's benefits at home. A growing number of skincare products are formulated with PDRN, which is also known to strengthen the skin barrier and reduce damage from environmental stressors—fine lines and irritation among them.
For a targeted addition to your skincare regimen, look to the likes of Rejuran's Derma Healer Moisture Treatment Essence or Medicube's PDRN Pink Peptide Glow Serum. Furthermore, the benefits of PDRN can extend across your entire skincare routine, courtesy of products like the calming Heveblue Salmon Caring Centella Light Cleansing Oil and Genabelle's PDRN Rejuvenating Toner.
The best options on the shelves cleverly blend PDRN with the benefits of other super-ingredients. Consider VT's Cica X Hylon PDRN Reedle Shot Cream, which is also infused with soothing cica for added nourishment, or Innisfree's Retinol Green Tea PDRN Skinbooster Ampoule, which brightens and boosts thanks to its retinol, green tea and PDRN trio.
Below, shop six of the best PDRN-powered products on the shelves right now: Courtesy of Innisfree
1 / 6 Innisfree Retinol Green Tea PDRN Skinbooster Ampoule
Innisfree cleverly combines the benefits of retinol, green tea and PDRN in this complexion-boosting ampoule. Specifically designed to be absorbed deeply within the skin's layers, expect to see a brightened mien and improvement in the appearance of wrinkles with consistent use.
Innisfree Retinol Green Tea PDRN Skinbooster Ampoule, $53 for 25ml, available from Innisfree Courtesy of Medicube
2 / 6 Medicube PDRN Pink Peptide Glow Serum
It's not for nothing that Medicube's products have attained viral status. This delightfully hued serum doubles down on the joy factor by promoting better skin elasticity, enhanced glow, and a more even complexion. PDRN is the powerhouse behind these luminous effects.
Medicube PDRN Pink Peptide Glow Serum, $29.90, available from Medicube Courtesy of Heveblue
3 / 6 Heveblue Salmon Caring Centella Light Cleansing Oil
Such is the versatility of PDRN that its benefits needn't be contained to specific serums. As Heveblue proves, even a cleansing oil can harness its merits. This water-light formula blends PDRN, apple seed oil and centella asiatica leaf water to deliver a hydrating, calming make-up remover that diminishes excess sebum and blackheads.
Heveblue Salmon Caring Centella Light Cleansing Oil, $35.61 for 250ml, available at Watson's Courtesy of VT
4 / 6 VT Cica X Hylon PDRN Reedle Shot Cream
A new take on PDRN—specifically, a plant-based form—arrives courtesy of this VT K-beauty staple. Also infused with soothing cica, a barrier of nourishment and moisture is formed on the skin upon application. Unveiled is a radiant skin tone and boosted elasticity for a revived complexion. VT Cica X Hylon PDRN Reedle Shot Cream, $86 for 50ml, available at Watson's Courtesy of Genabelle
5 / 6 Genabelle PDRN Rejuvenating Toner
Here's a reviving solution for skin that's dry or irritated. This targeted toner is backed by concentrated PDRN, fortifying panthenol and niacinamide to reduce roughness, dryness and flakiness, alongside the appearance of fine lines and dark spots. Talk about nourishment and hydration that goes all the way.
Genabelle PDRN Rejuvenating Toner, $30 for 300ml, available at Ksisters Courtesy of Rejuran
6 / 6 Rejuran Derma Healer Moisture Treatment Essence
Rejuran is widely recognised for the quality and efficacy of their PDRN-backed products. This essence encapsulates the ingredient's stunning effects. Honing in on reducing the appearance of wrinkles and brightening the skin, turn to this moisturising formula for a bright and replenished mien.
Rejuran Derma Healer Moisture Treatment Essence, $35.44, available at Olive Young