Cardinals at Guardians Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for June 27
It's Friday, June 27, and the Cardinals (44-38) are in Cleveland to take on the Guardians (40-39). Sonny Gray is slated to take the mound for St. Louis against Luis L. Ortiz for Cleveland.
Last night the Guardians were shut out by the Blue Jays and dropped the series 2-1.
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The Cardinals suffered a similar fate when they were shut out by the Chicago Cubs yesterday.
Let's dive into the matchup and find a sweat or two.
We've got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.
Game details & how to watch Cardinals at Guardians
Date: Friday, June 27, 2025
Time: 7:10PM EST
Site: Progressive Field
City: Cleveland, OH
Network/Streaming: Apple TV+
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Cardinals at the Guardians
The latest odds as of Friday:
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Moneyline: Cardinals (-129), Guardians (+108)
Spread: Cardinals -1.5
Total: 8.0 runs
Probable starting pitchers for Cardinals at Guardians
Pitching matchup for June 27, 2025: Sonny Gray vs. Luis L. Ortiz
Cardinals: Sonny Gray, (7-2, 3.72 ERA)
Last outing (Cincinnati Reds, 6/21): 5.0 Innings Pitched, 1 Earned Runs Allowed, 5 Hits Allowed, 2 Walks, and 5 Strikeouts Guardians: Luis L. Ortiz, (4-8, 4.30 ERA)
Last outing (Athletics, 6/21): 6.0 Innings Pitched, 0 Earned Runs Allowed, 2 Hits Allowed, 2 Walks, and 10 Strikeouts
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Top betting trends & insights to know ahead of Cardinals at Guardians
The Cardinals have won 4 of their last 5 games on the road
The Under is 8-2 in the Guardians' last 10 games
The Guardians have failed to cover the Run Line in 7 of their last 9 home games
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight's game between the Cardinals and the Guardians
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Friday's game between the Cardinals and the Guardians:
Moneyline: NBC Sports Bet is recommending a play on the St. Louis Cardinals on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Guardians at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
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