KYAN Technologies to Present New Data on Optim.AI™ Immunotherapy and Real-World Pan-Cancer Utility at AACR 2025
Data shows validation of FPM platform in breast cancer immunotherapy and 85% clinical concordance across over 20 solid cancers and hematologic malignancies.
SINGAPORE, SINGAPORE, SINGAPORE, April 19, 2025 / EINPresswire.com / -- KYAN Technologies Pte. Ltd. ('KYAN') today announced that two abstracts will be presented on its Optim.AI™ functional precision medicine platform at the American Association for Cancer Research (AACR) Annual Meeting 2025, taking place April 25 – 30, in Chicago, Illinois.
The two studies highlight the clinical utility and translational potential of Optim.AI™, a platform that rapidly identifies effective treatment combinations through ex vivo functional screening and combinatorial analytics, supporting both personalized patient care and oncology drug development.
BREAST CANCER IMMUNOTHERAPY: FUNCTIONAL COMBINATORIAL EVALUATION
In this study, KYAN researchers applied an experimental adaptation of the Optim.AI™ platform to evaluate immunotherapy combinations in breast cancer. The approach integrated high-content imaging, short-term 3D tumor-immune co-culture, and combinatorial analysis to rank the effectiveness of immunotherapy combinations in HER2-positive and triple-negative breast cancer spheroids co-cultured with peripheral blood mononuclear cells (PBMCs). The platform enabled real-time assessment of immune cell infiltration and tumor-specific killing, allowing for the phenotypic ranking of all possible combinations of from12 FDA-approved therapies, including ADCC/CDC antibodies and antibody-drug conjugates (ADCs).
'This study bridges a key gap in immunotherapy testing,' said Sharon Pei Yi Chan, Scientist at KYAN Technologies. 'By integrating multi-cellular, high-content screening with the Optim.AI™ platform, we're able to evaluate immunotherapy-based combinations in clinically relevant tumor models, using limited material and within a rapid timeframe. This creates a new path for functional, patient-specific immuno-oncology strategies.'
REAL-WORLD CONCORDANCE: MULTI-CANCER CLINICAL VALIDATION
A second study evaluated 75 retrospective and prospective clinical cases across more than 20 cancer types to assess the real-world concordance of Optim.AI™ with patient treatment outcomes. The platform demonstrated 85.4% concordance with actual clinical responses, accurately identifying both effective and resistant regimens. Cancer types included non-Hodgkin lymphoma, acute myeloid leukemia, sarcoma, breast, colorectal and ovarian cancers, amongst others, with sample sources such as bone marrow, peripheral blood, tissue biopsies, and pleural effusions. These results reinforce the platform's ability to distinguish treatments associated with clinical benefit from those unlikely to be effective, underscoring its clinical application across a diverse set of patient cases.
'These results validate the ability of Optim.AI™ to support therapeutic decision-making by accurately predicting both response and resistance,' said Dr. Edward Kai-Hua Chow, Chief Scientific Officer at KYAN Technologies. 'By functionally interrogating hundreds of treatment permutations using patient-derived samples, we can deliver clinically meaningful insights within days, helping clinicians make more informed and timely therapy choices.'
'We're bridging the cancer care gap by advancing revolutionary technologies that are clinically validated and built for real-world use,' said Hugo Saavedra, CEO of KYAN Technologies. 'Optim.AI™ is uniquely positioned to transform drug development and how treatment decisions are made by combining speed, precision, and wide applicability in a way traditional approaches simply can't. These new studies show how Optim.AI™ can help drug developers and clinicians uncover new and effective treatment options, whether through cutting-edge immunotherapy testing or pan-cancer functional precision medicine.'
Details on presentations are below:
Abstract Control Number: 4450
Title: Real-world concordance analysis of a combinatorial functional precision medicine platform, Optim.AI™, in both solid and hematological cancers
Session Title: Targeted Therapies and Combinations 4
Session Start Time: 4/30/2025 9:00:00 AM
Session End Time: 4/30/2025 12:00:00 PM
Location: Poster Section 35
Poster Board Number: 20
Presentation Number: 7214
Abstract Control Number: 4534
Title: Application of Optim.AI™ platform for predictive evaluation of immunotherapy combinations in breast cancer
Session Title: Drug Discovery Assay Technologies
Session Start Time: 4/29/2025 2:00:00 PM
Session End Time: 4/29/2025 5:00:00 PM
Location: Poster Section 16
Poster Board Number: 20
Presentation Number: 5492
ABOUT KYAN TECHNOLOGIES
KYAN Technologies is a functional precision medicine company advancing a platform for rapid, combination-focused cancer treatment insights. Its proprietary platform, Optim.AI™, uses experimentally derived data from patient tumor samples or preclinical models to identify effective drug combinations across a broad therapeutic search space.
KYAN's early work in combination therapy optimization revealed insights that led to the development of a scalable phenotypic screening approach designed to assess actual treatment response. Built on a clinically validated, evidence-based foundation, Optim.AI™ has demonstrated predictive accuracy across diverse cancer types and now informs both personalized oncology care and translational research, bringing clinically grounded understanding earlier into the drug development process.
KYAN is headquartered in Singapore and is expanding U.S. operations through a collaboration with Mayo Clinic Laboratories to support CLIA validation and scale drug development partnerships. The company will also participate in the AACR Oncology Industry Partnering Event to advance strategic collaborations with pharma and biotech innovators.
For media inquiries contact:
Sudha Sruthi, Corporate Development
email us here
Legal Disclaimer:
EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
an hour ago
- Yahoo
Salmonella outbreak linked to eggs sickens dozens of people across 7 states
More than 70 people across seven states have been sickened due to a salmonella outbreak linked to eggs recalled by a California-based egg distributor, according to the US Centers for Disease Control and Prevention. On Friday, the August Egg Company recalled 1.7 million dozen brown cage-free and brown certified organic eggs, sold under multiple brand names, that have the 'potential to be contaminated,' according to a recall notice from the US Food and Drug Administration. Of the 79 people sickened, 21 people have been hospitalized and no deaths have been reported, the CDC said. The eggs were sold to restaurants and retailers in Arizona, California, Illinois, Indiana, Nebraska, New Mexico, Nevada, Washington and Wyoming, according to the CDC. They were distributed at retail locations including Walmart, Save Mart, FoodMaxx, Lucky, Smart & Final, Safeway, Raleys, Food 4 Less and Ralphs. Salmonella can 'cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems,' according to the FDA. Salmonella can also cause fever, diarrhea, nausea, vomiting and abdominal pain in healthy people who get infected. 'August Egg Company is not selling fresh shell eggs at this time. Our firm has voluntarily been diverting eggs to an egg-breaking plant for over 30 days, which pasteurizes the eggs and kills any potential foodborne pathogens,' the company said in a statement provided to the FDA. 'It is important to know that when our processing plant identified this concern, we immediately began diverting all eggs from the plant to an egg-breaking facility, which pasteurizes the eggs and kills any pathogens.' The company also said its internal food safety team is 'conducting its own stringent review' to identify future preventative measures. 'We are committed to addressing this matter fully and to implementing all necessary corrective actions to ensure this does not happen again,' the company said. The CDC recommends that anyone who has the recalled eggs in their home or business throw them out or return them to the store where they were purchased.
Yahoo
an hour ago
- Yahoo
Bedner Growers tied to salmonella outbreak: See which cucumbers are recalled
Twenty-six people have been sickened, with nine of them being hospitalized, due to a salmonella outbreak linked to cucumbers sold across the country. Now some cucumbers are being recalled. Cucumbers grown by Florida-based Bedner Growers and distributed by Fresh Start Produce Sales are linked to a salmonella outbreak, the Centers for Disease Control and Prevention (CDC) and Food and Drug Administration (FDA) said in notices published May 19. As part of a follow-up inspection in April 2025, FDA investigators collected an environmental sample from Bedner Growers that tested positive for salmonella and matched recent clinical samples from ill people. No deaths have been reported so far, according to the FDA. Here's what to know about the recall and outbreak. Salmonella outbreak linked to cucumbers: More than 20 sickened in 15 states Bednar Growers is voluntarily recalling cucumbers sold at Bednar's Farm Fresh Market between April 29 and May 14, 2025. The cucumbers were sold directly to consumers at the three Bedner's Farm Fresh Markets locations in Florida (Boynton Beach, Delray Beach, and West Palm Beach). The FDA says the cucumbers may have been sold "individually or in smaller packages," with or without a label that may not bear the same brand, product name, or best by date. The vegetables were also sold to retailers, distribution centers, wholesalers, and food service distributors this spring. The agency did not identify specifically where the cucumbers were sold. According to the FDA, the products were labeled as either being "supers," "selects," or "plains" for distributors, restaurants and retailers who purchased the cucumbers. "Do not sell or serve whole cucumbers grown by Bedner Growers Inc. and distributed by Fresh Start Produce Inc. between April 29, 2025 to May 19, 2025," the FDA wrote. According to the FDA, if you have cucumbers at home and can't tell where they are from, throw them away. When eating out over the next week, consumers should ask if cucumbers were from Bednar Growers or Fresh Start Produce Sales Inc. Additionally, the FDA recommends washing surfaces and items that may have touched cucumbers using hot soapy water or a dishwasher. Businesses should not sell or serve cucumbers grown by Bednar Growers and distributed by Fresh Start Produce Inc. between April 29 and May 19, 2025. The FDA also recommends businesses wash and sanitize items and surfaces that may have come in contact with cucumbers, and stores should notify customers who may have purchased cucumbers using signs in stores or emails. As of May 20, the salmonella outbreak linked to cucumbers has sickened 26 people in the following 15 states: Alabama California Colorado Florida Illinois Kansas Kentucky Michigan North Carolina New York Ohio Pennsylvania South Carolina Tennessee Virginia According to the FDA, illness usually occurs within 12 to 72 hours after eating food that is contaminated with salmonella, and the symptoms usually last four to seven days. Symptoms include diarrhea, fever, and abdominal cramps. Children younger than five, the elderly, and people with weakened immune systems are more likely to have severe infections, the FDA says. Contact your healthcare provider immediately if you think you may have symptoms of a salmonella infection. Natalie Neysa Alund is a senior reporter for USA TODAY. Reach her at nalund@ and follow her on X @nataliealu Gabe Hauari is a national trending news reporter at USA TODAY. You can follow him on X @GabeHauari or email him at Gdhauari@ This article originally appeared on USA TODAY: Bedner Growers recalls cucumbers tied to salmonella outbreak
Yahoo
an hour ago
- Yahoo
FDA: More cucumbers, ready-to-eat products recalled in growing salmonella outbreak
A Maryland food company has recalled specific salsa and cucumber products because they were made with cucumbers that are possibly contaminated with salmonella. TGD Cuts, LLC of Jessup, Maryland, is recalling some tub and tray products because they contained cucumbers from Boynton Beach, Florida-based Bedner Growers Inc., which have been linked to a salmonella outbreak. TGD Cuts distributed the affected products, which included salsas, sliced cucumbers and cucumber spears, to retail and foodservice locations in Maryland, Virginia, Pennsylvania, New Jersey, and North Carolina, according to the Food and Drug Administration (FDA). The products had use-by dates ranging from May 20 to May 28 and are unlikely to be in stores or being used. No illnesses have been reported in connection with the products, the FDA said. Egg recall: Brown eggs sold at some Walmart stores have salmonella risk The initial May 19 recall involved cucumbers sold directly to consumers at Bednar's Farm Fresh Market, according to notices published May 19 by the Centers for Disease Control and Prevention (CDC) and the FDA. Subsequent recalls have been announced by grocers such as Harris Teeter, Kroger and Walmart for repackaged cucumbers for resale under different brand names or those used in ready-to-eat products, including vegetable trays and salads. The cucumbers, distributed by Fresh Start Produce Sales of Delray, Florida, also led to Target recalling individual cucumbers on May 30, specifically cucumber two-packs and various prepared foods products. In addition to the growing cucumber-related recall, other products have been recalled recently for potential salmonella contamination. The FDA on May 28 upgraded a recall of tomatoes distributed in three southern states to a Class I recall, meaning consumption of the food could cause serious health complications or lead to death. Then, on June 6, the CDC and FDA linked brown eggs sold in nine states – including at some Walmart stores – to an ongoing Salmonella Enteritidis outbreak, in which 79 people have been sickened and at least 21 hospitalized. Customers who purchased any products from TGD Cuts should get rid of them or return them for a full refund. Here is the list of products recalled due to a possible salmonella risk. Item UPC Use By Date Salsa, Hot 6/12 oz. 840219170534 5/25/2025 Salsa, Mild 6/12 oz. 840219170541 5/25/2025 Salsa, Mild 5lb. 840219140445 not available Salsa, Mild 5lb. 840219140445 5/28/2025 Cucumber Sliced/Grape Tomato 50/2 oz. 840219184784 5/23/2025 Cucumber Sliced Unpeeled 5lb. 840219160733 not available Cucumber Sliced Unpeeled 50/2 oz. 840219170657 5/19/2025 Cucumber Spears 50/2 oz. 840219179971 5/19/2025 Salmonella poisoning causes about 1.35 million illnesses, 26,500 hospitalizations, and 420 deaths each year in the U.S., according to the CDC and FDA. Symptoms, which include diarrhea, fever and stomach cramps, will usually occur six hours to six days after exposure and may last up to seven days. Symptoms from severe infections may include aches, headaches, elevated fever, lethargy, rashes, and blood in urine or stool. Mike Snider is a reporter on USA TODAY's Trending team. You can follow him on Threads, Bluesky, X and email him at mikegsnider & @ & @mikesnider & msnider@ What's everyone talking about? Sign up for our trending newsletter to get the latest news of the day This article originally appeared on USA TODAY: More cucumbers recalled for salmonella risk, FDA says
