Chicago White Sox at Cincinnati Reds odds, picks and predictions
The Cincinnati Reds (20-23) host the Chicago White Sox (13-29) in the second game of a 3-game set on Pete Rose Night Wednesday at Great American Ball Park. First pitch is scheduled for 7:14 p.m. ET, a tribute to the late Pete Rose, who wore No. 14. Rose was among several previously banned players posthumously reinstated by MLB Tuesday. Let's analyze BetMGM Sportsbook's MLB odds around the White Sox vs. Reds odds and make our expert MLB picks and predictions for the best bets.
Season series: White Sox lead 1-0
Chicago has won back-to-back games after taking down Cincinnati 5-1 in 10 innings Tuesday as a +186 road underdog. The White Sox scored 4 runs in the 10th inning, cemented by a 3-run home run from 3B Miguel Vargas to secure the win.
Cincinnati has lost back-to-back games after falling Tuesday as a -205 home favorite. The Reds have managed just 1 run over their last 2 games, following a 13-run outburst Saturday. Their lone run came on a game-tying home run by SS Elly De La Cruz in the bottom of the ninth. RP Emilio Pagan took his second loss of the season, surrendering 3 earned runs over 1 2/3 innings.
White Sox at Reds projected starters
RHP Davis Martin vs. LHP Nick Lodolo
Martin (1-4, 4.01 ERA) makes his eighth start and ninth appearance. He has a 1.41 WHIP, 2.5 BB/9 and 5.9 K/9 through 42 2/3 innings.
Last start: Loss, 4 1/3 IP, 4 ER, 7 H, 1 BB, 5 K in 10-0 defeat at Kansas City Royals Thursday
2025 road stats: 0-3, 4.87 ERA (20 1/3 IP, 11 ER), 22 H, 8 BB, 12 K in 3 starts and 1 relief appearance
Has never faced Reds
Lodolo (3-3, 3.23 ERA) makes his ninth start. He has a 1.01 WHIP, 1.3 BB/9 and 7.2 K/9 through 47 1/3 innings.
Last start: No-decision, 6 IP, 2 ER, 5 H, 0 BB, 7 K in a 5-4 setback at Atlanta Braves Thursday
2025 home stats: 1-1, 6.75 ERA (16 IP, 12 ER), 20 H, 3 BB, 11 K in 3 starts
2024 vs. White Sox: 1 road start (April 13), win, 5 2/3 IP, 0 ER, 1 H, 1 BB, 10 K in 5-0 victory
Career vs. White Sox: 1-0, 2.89 ERA (9 1/3 IP, 3 ER), 7 H, 2 BB, 13 K in 2 starts
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White Sox at Reds odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:45 p.m. ET.
Moneyline (ML) : White Sox +185 (bet $100 to win $185) | Reds -225 (bet $225 to win $100)
: White Sox +185 (bet $100 to win $185) | Reds -225 (bet $225 to win $100) Run line (RL)/Against the spread (ATS) : White Sox +1.5 (-110) | Reds -1.5 (-110)
: White Sox +1.5 (-110) | Reds -1.5 (-110) Over/Under (O/U): 8.5 (O: -118 | U: -102)
White Sox at Reds picks and predictions
Prediction
Reds 5, White Sox 2
PASS.
There is minimal value on the Reds (-225), who will see Lodolo take the mound with the best BB/9 in the majors. Expect the Reds to snap their offensive drought on Pete Rose Night in front of an energetic home crowd.
The White Sox have dropped 4 of their last 5 road games.
BET REDS -1.5 (-110).
Three of Chicago's last 5 losses have come by at least 2 runs, and the team has scored 1 or fewer in 4 of its last 8 games. Martin enters with a 4.01 ERA and is coming off a rough outing in which he allowed 4 earned runs over just 4 1/3 innings. In contrast, Lodolo is coming off a strong performance: 2 earned runs over 6 innings with 7 strikeouts and no walks.
While the Reds have hit a wall offensively, they have scored 4 or more runs in 3 of their last 6 games.
BET UNDER 8.5 (-102).
The Reds have hit the Under in 7 of their last 9 games, including 3 of their last 4 and 2 straight at home. They have scored 1 or fewer runs in 3 of their last 4 games, while allowing 4 or fewer in 5 of their last 9.
The White Sox have hit the Under in 6 of their last 8 games, including 3 straight. They have allowed 3 or fewer runs in 4 straight games and 4 or fewer in 8 of their last 9.
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