Liver damage warning signs: Constant itching on hands and feet could be serious

Time of India

6 days ago

Itchy hands and feet are commonly mistaken for dry skin, allergies, or minor irritations. However, when the itching is persistent, unexplained, and occurs without a visible rash, it could signal an underlying liver problem.
Medical experts highlight that such itching, especially when concentrated on the palms and soles, may result from a buildup of bile acids in the bloodstream due to impaired liver function. This condition is often associated with disorders like cholestasis or liver cirrhosis. If the itching worsens at night, doesn't respond to moisturisers, or is accompanied by fatigue or jaundice, it's essential to consult a doctor promptly.
Why liver damage can cause
itching on hands and feet
When the liver is not functioning properly, bile acids and toxins can build up in the bloodstream. These substances may then irritate nerve endings under the skin, leading to an intense, persistent itch, especially on the palms of the hands and soles of the feet.
This condition is known as cholestatic pruritus, and it often occurs without a visible rash, making it harder to diagnose. It is commonly linked to liver disorders such as:
Primary biliary cholangitis (PBC)
Primary sclerosing cholangitis (PSC)
Cirrhosis
Intrahepatic cholestasis of pregnancy (ICP)
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Causes of itching in liver disease:
Scientists have not yet pinpointed a single cause behind the itching (pruritus) associated with liver disease. According to Healthline, it is believed to result from a combination of factors, which may include:
1. Bile salts
In liver disease, bile salts can accumulate beneath the skin, potentially triggering itching.
However, this link isn't consistent, some individuals with high bile salt levels don't experience itching, while others itch despite normal levels.
2. Histamines
Many people with liver-related itching have elevated histamine levels, although antihistamines are often ineffective in providing relief.
3. Serotonin
Serotonin may influence how the brain perceives itching, though its exact role remains unclear. Some studies suggest it can enhance itch sensations by interacting with specific receptors in the nervous system, potentially complicating treatment for chronic itch conditions linked to neurological or psychological factors.
4. Pregnancy and hormone therapy
Itching can worsen during pregnancy or while undergoing hormone replacement therapy, likely due to hormonal fluctuations.
5. Serum alkaline phosphatase (ALP)
Elevated ALP levels are frequently seen in individuals experiencing itch-related liver conditions, suggesting a possible connection.
Key symptoms to watch for
It's important to differentiate everyday skin irritation from liver-related itching. Below are signs that your itching may be a warning from your liver:
Itching without a rash
Most skin conditions cause itching accompanied by redness, bumps, or inflammation.
In contrast, liver-related itching is intense yet rash-free, affecting deep layers under the skin.
It worsens at night
Liver-related itching typically becomes more severe in the evening or during sleep. Night-time itching can severely affect your quality of life and disrupt rest.
It starts on hands and feet
I
tchiness often begins in the palms and soles before spreading. These areas are sensitive to bile salt accumulation, a hallmark of liver dysfunction.
Associated liver symptoms
Other signs of liver problems may include:
Fatigue
Yellowing of the skin or eyes (jaundice)
Dark urine
Pale stools
Unexplained weight loss
When to consult a doctor
You should seek medical advice if:
Itching is persistent, unexplained, or resistant to moisturisers
You notice signs of jaundice or chronic fatigue
The itching is disrupting your sleep or daily life
A healthcare provider may order liver function tests, including bilirubin, alkaline phosphatase (ALP), and ultrasound scans to investigate further.
Tips to prevent itching and protect your skin
Avoid scratching, even when the urge is strong, as it can break the skin and increase the risk of infection. If nighttime itching is a problem, consider wearing gloves to bed to prevent unconscious scratching.
Here are additional ways to soothe itching and reduce skin irritation:
Bathe or shower with warm or cool water, never hot.
Limit time spent in hot environments or direct sunlight.
Use mild, fragrance-free soaps to avoid further irritation.
Apply gentle, unscented moisturisers regularly to keep skin hydrated.
Use a cold, damp cloth on itchy areas to ease discomfort.
Stay away from substances or materials that irritate your skin.
Wear gloves when handling harsh cleaning products or chemicals.
Opt for loose, breathable clothing to prevent chafing.
Use a humidifier in dry weather, especially during winter.
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