Latest news with #Raoof
The Citizen
10 hours ago
- The Citizen
Metro Police seeks dogs for training
THE Durban Metro Police Department is reaching out to the public for assistance in sourcing dogs to be trained as police dogs. 'We specifically require German Shepherds and Malinois breeds, preferably between the ages of 18 months to two years old. It is crucial that the dogs meet certain criteria to be considered for training within the police structure. However, if a dog does not meet the necessary standards, it will be returned to the owner. 'Your co-operation and contribution will be greatly appreciated and will go a long way in assisting the efforts of preventing crime in the dedicated police force,' said spokesperson for Durban Metro Police, Colonel Boysie Zungu. Should one wish to donate a dog that meets the requirements, please contact Lt. Col. Raoof on 083 261 4315 or Inspector Hammond on 071 515 5990. For more from Berea Mail, follow us on Facebook, X and Instagram. You can also check out our videos on our YouTube channel or follow us on TikTok. Click to subscribe to our newsletter – here At Caxton, we employ humans to generate daily fresh news, not AI intervention. Happy reading!
The Citizen
11 hours ago
- The Citizen
Metro Police seek German Shepherds and Malinois for K9 Force
THE Durban Metro Police Department is reaching out to the public for assistance in sourcing dogs to be trained as police dogs. 'We specifically require German Shepherds and Malinois breeds, preferably between the ages of 18 months to two years old. It is crucial that the dogs meet certain criteria to be considered for training within the police structure. However, if a dog does not meet the necessary standards, it will be returned to the owner. 'Your co-operation and contribution will be greatly appreciated and will go a long way in assisting the efforts of preventing crime in the dedicated police force,' said spokesperson for Durban Metro Police, Colonel Boysie Zungu. Should one wish to donate a dog that meets the requirements, please contact Lt. Col. Raoof on 083 261 4315 or Inspector Hammond on 071 515 5990. For more from Northglen News, follow us on Facebook , X or Instagram. You can also check out our videos on our YouTube channel or follow us on TikTok. Click to subscribe to our newsletter – here At Caxton, we employ humans to generate daily fresh news, not AI intervention. Happy reading!
The Citizen
12 hours ago
- The Citizen
Durban Metro Police call on public to donate dogs for K9 Unit Training
THE Durban Metro Police Department is reaching out to the public for assistance in sourcing dogs to be trained as police dogs. 'We specifically require German Shepherds and Malinois breeds, preferably between the ages of 18 months to two years old. It is crucial that the dogs meet certain criteria to be considered for training within the police structure. However, if a dog does not meet the necessary standards, it will be returned to the owner. 'Your co-operation and contribution will be greatly appreciated and will go a long way in assisting the efforts of preventing crime in the dedicated police force,' said spokesperson for Durban Metro Police, Colonel Boysie Zungu. Should one wish to donate a dog that meets the requirements, please contact Lt. Col. Raoof on 083 261 4315 or Inspector Hammond on 071 515 5990. For more from the Highway Mail, follow us on Facebook , X and Instagram. You can also check out our videos on our YouTube channel or follow us on TikTok. Click to subscribe to our newsletter here At Caxton, we employ humans to generate daily fresh news, not AI intervention. Happy reading!
BBC News
23-04-2025
- Automotive
- BBC News
Permanent Sheffield minicab signage plans reckless, says union
A council proposal for private hire vehicles to permanently fix signs to their front doors has been deemed "expensive and reckless" by a trade Raoof, the taxi trade representative for the GMB in Yorkshire, said Sheffield City Council's plan would confuse the public, put drivers at risk of abuse and damage cars, making them difficult to sell in said: "They don't need to be permanent, unless the council is wishing to take on the cost of damage and repair to the vehicle. It is a draconian measure, and it is not proportionate."Sheffield City Council has been approached for comment. The plan would only affect private hire vehicles (PHVs), also called minicabs, which are booked in advance through companies like Uber and Raoof, a former taxi driver, said: "[The plan] would mean being identified as a driver even when you're off duty with your family. There will be huge consequences."He previously told the BBC that drivers had suffered verbal and physical abuse during riots in August, with one union member having their window smashed while taking a passenger back to work at a hospital. 'Collective punishment' A petition against the plan has more than 300 signatures, with supporters saying they have had eggs and stones thrown at their vehicles while petition requests that the plan is dropped, and for any future proposal to be developed in consultation with drivers and only require non-permanent, magnetic from the Department for Transport said councils should not go further than requiring drivers to display an authority licence plate and a "pre-booked only" sign on the Raoof said it was "not valid" to justify permanent signage with safeguarding concerns."The problems have been addressed, and the customer always has the option of ringing the operator and speaking to someone as well."Collective punishment of thousands of [PHV] drivers because of one or two bad apples is extremely unproportionate," he rides through an app means information about the driver and vehicle are shared with the customer who can compare details when they taxis, which are those hailed on the street or booked at a taxi rank with a yellow sign on the roof, are not included in the proposal. Listen to highlights from South Yorkshire on BBC Sounds, catch up with the latest episode of Look North
Los Angeles Times
09-04-2025
- Health
- Los Angeles Times
City of Hope Study Demonstrates Proof of Concept for Targeted New Approach to Treat Pancreatic Cancer
Scientists Transform Genetic Culprit Behind Treatment Resistance into a Skillful Tool to Use Against Cancer Researchers at City of Hope have identified a new molecular target for treating pancreatic cancer, according to a new gastroenterology study. Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human cancers worldwide because it evades most treatments. With few therapeutic options, 90% of these patients don't survive beyond five years. Now an innovative new approach offers the potential for transforming the genetic culprit behind PDAC's stubborn resistance to treatment into a therapeutic ally. Led by Mustafa Raoof, M.D., M.S., City of Hope assistant professor of surgery, cancer genetics and epigenetics, scientists focused on transcription-replication conflicts (TRCs), which occur when the mechanisms responsible for gene expression and genome duplication collide. The clash disrupts cells' ability to read and copy genes, leading to replication stress, a frequent phenomenon in pancreatic cancer. The added stress causes cells to make errors copying their DNA, enabling cancer to gain a foothold and spread. 'Transcription-replication conflicts are an important vulnerability of pancreatic cancer,' said Dr. Raoof, who served as senior author of the new study. 'Our study is the first to confirm proof of concept for whether exploiting this chink in cancer's armor could provide an effective therapeutic target for patients.' In an earlier study, Dr. Raoof and his colleagues had identified high levels of TRCs as a unique weakness in pancreatic cancers that are driven by a common gene mutation. Building upon this research, his team used an experimental drug developed at City of Hope called AOH1996 as a tool to target TRCs and measure clinical responses. First, the laboratory tested AOH1996 on a mouse model for pancreatic cancer and on small, lab-grown versions of human organs called organoids. The scientists discovered that the drug slowed tumor growth, damaged tumor cells without harming healthy tissue and boosted mouse survival from a median of 14 days to three weeks. Next, the team tested the approach on two patients whose pancreatic tumors had resisted earlier treatments (NCT05227326). The patients experienced up to a 49% shrinkage in their liver metastases after taking the pill twice a day for two months. Overall, the experimental approach was most effective at killing cancer cells with high replication stress, a common phenomenon that occurs when the KRAS gene goes awry in 95% of patients with pancreatic cancer. 'While the KRAS mutation has suggested a strong therapeutic target, pinpointing it in human PDAC has been difficult until now,' said Dr. Raoof. 'With inhibitors to mutant KRAS entering clinical trials, resistance is expected. It's crucial for us to develop new approaches that target dependency on KRAS.' Targeting TRCs enabled the scientists to pinpoint only pancreatic cancer cells that experienced high levels of replication stress. 'Transcription-replication conflicts are more prevalent in cancer cells than normal cells,' Dr. Raoof said. 'Therapies that interfere with how cells manage their DNA during replication could open up new ways to treat cancer, offering hope for patients who have not benefited from other approaches.' Though excited by the study's early results, Dr. Raoof emphasized caution in interpreting its findings. Due to the trial's small size, scientists will need to pursue larger clinical and biomarker discovery studies to realize the full potential of therapeutic targeting of TRCs. A respected birthplace for biotech, City of Hope created the technology that led to the development of synthetic human insulin. City of Hope later contributed to the development of 'smart' cancer drugs like Herceptin, Rituxan and Avastin. Information was sourced from BusinessWire. To learn more, contact zlogsdon@
