
Raymond James Predicts Up to ~760% Surge for These 2 ‘Strong Buy' Stocks
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Naturally, all this has stirred up some uncertainty – especially for investors trying to read the tea leaves on inflation, supply chains, and overall market direction. And yet, Raymond James CIO Larry Adam sees plenty of reason for optimism when looking at the bigger picture.
'For investors, market ups and downs are nothing new. Despite interim setbacks, the S&P 500 has delivered a robust average annual return of ~11% since 1985. Bull markets historically last six times longer than bear markets and produce returns five times more powerful. The takeaway? Stay focused on the long term,' Adam notes.
That long-term perspective leads to a clear track, and Adam elaborates on it, saying, 'We continue to favor U.S. equities, where the outlook remains brighter… We expect two rate cuts by year end and two more in 2026, helping growth pick up to 1.5% next year. Trump's 'One Big Beautiful Bill' could also provide a modest boost, even if it adds to the deficit.'
Against this backdrop, Raymond James analysts have zeroed in on two stocks they believe are set for substantial growth in the coming year – including one with a potential upside as high as 760%.
As if that weren't compelling enough, both names also earn a Strong Buy rating from the analyst consensus, according to the TipRanks database. Let's break down what's behind the bullish sentiment.
Achieve Life Sciences (ACHV)
We'll start with a stock that is bursting with upside potential. Achieve Life Sciences is both a biopharmaceutical company and a penny stock – two niches known for their ability to deliver outsized returns. Central to the company's growth story is its lead program: developing treatments for nicotine dependence.
Nicotine, the key addictive ingredient in tobacco products, has been connected to multiple health problems, including recurrent headaches, high blood pressure, dangerous blood clotting, sleep disorders, and changes in heart rhythm. The most common way that people satisfy their nicotine cravings is through smoking, which brings along its own array of health issues, from COPD to various cancers.
This isn't just a health challenge – it's a massive market opportunity. There are 29 million smokers in the US alone, some 16 million Americans living with smoking-related illnesses, and globally, about 8 million smoking-related deaths each year.
Achieve is targeting the problem with the development of cytisinicline, a naturally derived drug candidate designed to reduce withdrawal symptoms and make it easier to quit smoking or vaping.
What sets cytisinicline apart is its robust clinical profile. The drug has delivered strong Phase 3 data on smoking cessation, with a favorable safety record to match. In the ORCA-2 and ORCA-3 trials, cytisinicline consistently produced statistically significant improvements in abstinence rates versus placebo. In ORCA-3, 30.3% of participants in the 12-week arm achieved continuous abstinence during weeks 9 to 12, compared to 9.4% with placebo, and about 20.5% remained abstinent through week 24 versus 4.2% for placebo. The safety profile was favorable, with mostly mild to moderate side effects and no treatment-related serious adverse events. These findings were reinforced by the ORCA-OL trial, where the independent DSMC's third safety review identified no concerns with long-term cytisinicline use.
Now, Achieve is gearing up for the next phase: FDA approval and commercial launch. At the end of June, the company submitted a New Drug Application (NDA) to the FDA. If approved, cytisinicline will become the first FDA-approved drug therapy for nicotine addiction in the past two decades. To support its commercialization efforts, Achieve recently announced a strategic partnership with Omnicom and has raised about $45 million.
Moreover, Achieve is not stopping with traditional smokers. The company is advancing cytisinicline as a potential treatment for nicotine dependence in e-cigarette users as well. In the Phase 2 ORCA-V1 trial, cytisinicline produced higher quit rates than placebo among individuals seeking to quit vaping, with no serious adverse events reported. Following these results, Achieve held an end-of-Phase 2 meeting with the FDA and reached agreement on the design of a pivotal Phase 3 trial for vaping cessation. With that green light, the company plans to kick off the ORCA-V2 Phase 3 study in the first half of 2026.
Put it all together – the compelling data, the unmet need, the imminent FDA milestone, and a bargain-bin $2.32 share price – and it's no wonder Raymond James analyst Gary Nachman thinks now is the time to get in on the action.
'Our Strong Buy rating is supported by a significant unmet need still in the [nicotine addiction] market that is a major global public health concern, with current options resulting in very low quit rates. Cytisinicline has a compelling clinical profile with strong Phase 2/3 data. Cytisinicline shows high smoking cessation quit rates and a favorable safety profile compared to PFE's Chantix (peak sales $1.1B) that is now generic. Cytisinicline has a proven mechanism that is similar to Chantix, but is naturally derived and more selective resulting in fewer AEs, has 50+ years of safe use in E. Europe, and now a submitted NDA with a de-risked regulatory pathway,' Nachman opined.
'There is a large opportunity in smoking cessation that is ripe for the taking and an expanded partnership with Omnicom should help with the US launch, and potentially big upside from vaping as well… A partnership/acquisition to maximize value is possible,' the analyst added.
All of this helps explain Nachman's Strong Buy rating on ACHV, which comes with a $20 price target. If his thesis plays out, investors could be looking at a whopping ~760% gain over the next 12 months. (To watch Nachman's track record, click here)
And it's not just Nachman who sees big upside here. The broader analyst community is similarly upbeat: in the past 3 months, ACHV has picked up 4 Buy ratings with no Holds or Sells, earning it a consensus Strong Buy status on Wall Street. Meanwhile, the average price target of $15.25 points to a 557% upside from current levels. (See ACHV stock forecast)
Avidity Biosciences (RNA)
The next stock catching Raymond James' attention is Avidity Biosciences, a clinical-stage biotech firm aiming to develop a new class of RNA therapeutics – drug candidates designed to tackle the root genetic causes behind a variety of serious diseases. The company is building its pipeline using its proprietary Antibody Oligonucleotide Conjugates platform, or AOC. This platform blends the targeting abilities of monoclonal antibodies with the gene-silencing power of oligonucleotide therapies, creating agents that can home in on disease drivers at the genetic level with notable selectivity and precision. Through this approach, Avidity aims to address conditions that have long eluded effective treatment.
At present, the company's primary targets are skeletal muscle diseases, especially within the muscular dystrophy class. Avidity has developed a robust research pipeline, which includes three lead drug candidates that are advancing through clinical trials. These three programs – Del-zota, Del-desiran, and Del-brax – are each aimed at specific muscle disorders: Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), and facioscapulohumeral muscular dystrophy (FSHD), respectively.
Each of these candidates has shown solid progress. Del-zota, Avidity's program for Duchenne muscular dystrophy, has demonstrated strong increases in exon skipping and dystrophin production, along with an encouraging safety profile. Based on these results, the company expects to submit its first Biologics License Application (BLA) for del-zota by year-end.
Meanwhile, del-desiran has delivered impressive data in early clinical trials, with patients experiencing not only reductions in toxic RNA but also meaningful signs of functional improvement. These encouraging results have been further supported by the ongoing MARINA-OLE extension study, which continues to show sustained benefit with longer-term treatment. On the strength of these findings, the program advanced into the pivotal Phase 3 HARBOR trial. The company previously noted that enrollment would be completed by mid-2025, setting the stage for comprehensive data readouts in the first half of 2026.
Rounding out the pipeline, the del‑brax program for FSHD is also advancing steadily. Initial data from the FORTITUDE study demonstrated significant reductions in DUX4 gene expression, and with an FDA‑validated accelerated approval pathway now in place, Avidity launched the pivotal FORWARD Phase 3 trial. This global, 18‑month, randomized, placebo‑controlled study is expected to deliver topline results by H2 2026.
With all three programs advancing toward key clinical and regulatory milestones, Raymond James analyst Martin Auster sees strong prospects for success here.
'We have high conviction in del-zota (DMD44) to become the first approved drug from Avidity's antibody oligonucleotide conjugate (AOC) platform. Del-desiran (DM1) has been derisked through Ph1/2 biomarker and functional data, and a positive Ph 3 outcome in ~H1 2026 could be transformative for Avidity given del-desiran's first-mover potential and a large DM1 market opportunity (~$5B+ TAM). Del-brax has an even larger potential first-mover advantage in FSHD (opportunity for a strong competitive moat); we project accelerated approval in 2027 supported by cDUX biomarker data and 12-month placebo-controlled functional data,' Auster stated.
Auster's high conviction is reflected in his Strong Buy rating on RNA and a $65 price target, which suggests a potential 107% upside from current levels. (To watch Auster's track record, click here)
That's far from the only upbeat take on this stock. RNA enjoys a Strong Buy consensus, based on 18 recent analyst ratings – with 17 Buys and just a single Hold. At its current price of $31.45, the stock's average target price of $64.44 suggests RNA could surge ~105% in value over the next year. (See RNA stock forecast)
To find good ideas for stocks trading at attractive valuations, visit TipRanks' Best Stocks to Buy, a tool that unites all of TipRanks' equity insights.
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Newsweek
31 minutes ago
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But the whiplash-inducing U-turn on energy policy in the U.S. is starkly at odds with signals from the broader energy market. In the U.S., renewable energy now accounts for about 90 percent of the new electricity capacity being added to the grid as wind, solar and batteries have become the cheapest and fastest sources of new power. In the series "Climate Investing in a Volatile Climate" we'll hear from leading climate tech investors about how they are navigating the rapid shifts in U.S. policy and the energy markets. In the series "Climate Investing in a Volatile Climate" we'll hear from leading climate tech investors about how they are navigating the rapid shifts in U.S. policy and the energy markets. 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"We're taking on outsized risk and maybe doing that at an earlier time or in a different way than even other climate-oriented venture funds might be willing," she said. "We're looking for giga-scale impact." One budding success story, she said, is the low-carbon cement company Sublime Systems. Azolla was an early backer, and Sublime recently signed a deal with Microsoft that is the largest procurement deal for clean cement to date. Azolla's approach also assumes a long lead time for nascent clean technologies to develop, she explained, a mindset that is less susceptible to shifting political winds. "When we're evaluating companies for investment, we're looking at market growth and emissions avoided out to 2050," Wolfson said. "That's a lot longer than a four-year administration." 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Yahoo
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Newsweek
36 minutes ago
- Newsweek
Student Loan Update: Gen Z Hit With Highest Payments
Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. Millions of Americans with federal student loans have seen a sharp rise in monthly payments, with Gen Z borrowers now facing the steepest costs. New survey data from Empower reported that Gen Z participants pay an average of $526 per month toward student loans, significantly above the overall average payment of $284 for all age groups. The findings come as borrowers respond to the end of pandemic-era payment relief and major legislative changes in 2025 that eliminated income-driven repayment options, increasing financial strain for the newest generation in the workforce. Why It Matters The surge in loan payments for Gen Z is reshaping the financial futures of millions of young Americans. 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"Over the years, those rates have steadily climbed, and this generation is bearing the brunt of that increase. As a result, their monthly payments are significantly higher than those of previous borrowers." Across all borrowers surveyed, 34 percent said they were paying $200 or more per month. The added stress has not only affected finances but also mental health, with 59 percent of borrowers reporting anxiety related to their debt. And borrowers are not always prioritizing their student loan debt, as 54 percent said they prioritize other types of debt, like credit cards and car loans. The burden on Gen Z has grown in the wake of the One Big Beautiful Bill Act signed by President Donald Trump that removed the income-driven repayment plans established during President Joe Biden's administration. Under the new law, available repayment options provide less relief for those earning lower incomes, especially younger borrowers just starting their careers. The end of the pandemic-era forbearance and stricter repayment requirements have produced heightened monthly payments, with substantial repercussions for budgeting and debt prioritization among Gen Z and millennials. Collectively, Americans now owe more than $1.7 trillion in student loan debt, with balances having increased sixfold since 2003. As of 2024, 42.7 million Americans held federal student loans, and a significant portion are delinquent on their payments. As loan repayment resumed, only 22 percent of Gen Z borrowers felt confident about paying back their student loans, Empower found. Half of all borrowers contributed less to savings or retirement accounts as a result of their debt. Additionally, the lingering debt has led 42 percent of borrowers to wish they had chosen a different major or school, and 57 percent now say they regret their level of indebtedness. "Long-term, this is going to delay major milestones: starting families, buying homes and climbing the career ladder," Thompson said. "Many will feel pressured to stay with companies that offer student loan repayment perks, curbing their upward mobility and locking them into jobs they might otherwise leave." What People Are Saying Rebecca Rickert, head of communications and consumer insights at Empower, told Newsweek: "When post-grads are spending over $500 a month on loan payments, it can push other financial priorities like emergency savings or homeownership down the list. This is often coupled with more reliance on credit, and later entry into financial independence." Leslie Silva, principal attorney with McCall Sweeney & Silva P.C and a student loan expert, told Newsweek: "The current student loan system, and the changes in the new domestic policy bill, do nothing to help borrowers alleviate the burden of the cost of higher education. Half of millennial and Gen X borrowers have suffered delays in other major financial decisions due to student loan debt. The new bill places limits on what parents and borrowers can apply for to fund higher education. While some hope that these limits force institutions to lower their costs, that is a very unlikely outcome." Kevin Thompson, CEO of 9i Capital Group and the host of the 9innings podcast, told Newsweek: "The current student loan system, in my opinion, was designed to keep borrowers tied to the workforce. This wasn't by accident, it was by design. By saddling young people with debt early, the system ensures a steady flow of labor from a group that must keep earning just to stay afloat." Alex Beene, a financial literacy instructor at the University of Tennessee at Martin, told Newsweek: "They [Gen Z] enrolled and completed college at a time when the cost of tuition and housing had risen dramatically, and, on top of those elevated prices, those who attended in the last few years have had to take out loans with higher interest rates. The result is higher monthly payments that are creating real hardship for some borrowers who are just getting started in their careers." What Happens Next Borrowers previously enrolled in income-driven plans face a transition period of at least one year and, starting July 2026 to July 2028, will have select new repayment arrangements as the latest legislation takes effect. Gen Z and other borrowers are likely to face ongoing financial strain, delayed major life decisions, and an increasing demand for financial guidance amidst the rapidly changing student loan policy landscape. Silva said that moving forward, students and parents should expect to pay more out of pocket or rely more on private loan companies as the changes take effect. "We can expect to see a resurgence in private student loans forcing new student borrowers into even more debt at higher interest rates. Private student loan companies do not have a limit on applicable interest rates, whereas federal student loans do," Silva said. And the more debt student borrowers have, the longer it will take them to buy homes or contribute to retirement plans, Silva added. "It is possible we could see more support from the institutions themselves, but there has not been much evidence to support a decrease in the cost of higher education," Silva said.