What is Glioma? The rare brain cancer behind actress Kelley Mack's tragic death at 33
, best known for her role as Addy in
The Walking Dead
, has died at the age of 33 after a valiant battle with
glioma
, a rare and devastating type of
brain cancer
that strikes the central nervous system.
Mack passed away on August 2, surrounded by family in her hometown of Cincinnati. The news was confirmed in a heartfelt
social media
post by her sister Kathryn, who praised the actress's strength, calling her 'a bright, fervent light' who met her battle with 'bravery and grace.'
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What is Glioma?
Gliomas are tumors that arise from glial cells, which support and protect neurons in the brain and spinal cord. They are among the most common types of brain tumors, but the specific type that afflicted Mack, known as
diffuse midline glioma
, is exceedingly rare, highly malignant, and difficult to treat.
These tumors often grow in critical areas like the brainstem, thalamus, and spinal cord, regions responsible for vital functions such as breathing, movement, and consciousness. Their diffuse (spread-out) nature makes them almost impossible to surgically remove.
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Mack revealed last year that her tumor had affected her spinal cord. 'Due to the biopsy surgery on my spinal cord, I have lost the use of my right leg and most of my left leg,' she wrote in a January Instagram post. Despite limited mobility, she remained optimistic and shared videos of her physical progress with the help of her partner.
Why is Glioma so devastating?
Diffuse midline glioma carries one of the worst prognoses among all cancers. It is known for its rapid progression, resistance to chemotherapy and radiation, and minimal treatment options. Most cases are diagnosed in children, but Mack's diagnosis as a young adult highlights the unpredictable nature of the disease.
Medical experts say the exact causes are still unclear. Research into genetic mutations and targeted therapies is ongoing, but there is currently no known cure.
Rise of Kelley
Born Kelley Lynne Klebenow on July 10, 1992, Mack began her acting career in commercials. She went on to appear in popular television series such as The Walking Dead, Chicago Med, and 9-1-1. She also voiced Gwen Stacy in Spider-Man: Into the Spider-Verse and starred in several independent films including Broadcast Signal Intrusion and Mr. Manhattan.
Beyond acting, Mack was a filmmaker and storyteller. She wrote, directed, and edited short films like Positive, and was an executive producer on the upcoming feature Universal.
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