
Antarctic climate shifts threaten ‘catastrophic' impacts globally
More broadly, a state-of-knowledge review by a score of top experts revealed accelerating shifts across the region that are often both cause and effect of global warming, according to a study published in Nature.
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'Antarctica is showing worrying signs of rapid change across its ice, ocean and ecosystems,' lead author and Australian National University professor Nerilie Abram told AFP.
'Some of these abrupt changes will be difficult to stop.'
Shifts in different facets of Antarctica's climate system amplify each other and have accelerated the pace of warming globally as well, she said.
The study looked at evidence of abrupt change -- or 'regime shifts' -- in sea ice, regional ocean currents, the continent's ice sheet and ice shelves, and marine life. It also examined how they interact.
Floating sea ice does not add to sea level when it melts. But its retreat does replace white surfaces that reflect almost all of the Sun's energy back into space with deep blue water, which absorbs the same amount instead.
Ninety percent of the heat generated by manmade global warming is soaked up by oceans.
Retreating sea ice
After increasing slightly during the first 35 years that satellite data was available, Antarctic sea ice cover plunged dramatically over the last decade.
Since 2014, sea ice has retreated on average 120 kilometres (75 miles) from the continent's shoreline. That contraction has happened about three times faster in 10 years than the decline in Arctic sea ice over nearly 50.
The 'overwhelming evidence of a regime shift in sea ice' means that, on current trends, Antarctica could essentially become ice free in summer sooner than the Arctic, the study found.
This will speed up warming in the region and beyond, and could push some marine species toward extinction.
Over the last two years, for example, helpless emperor penguin chicks perished at multiple breeding grounds, drowning or freezing to death when sea ice gave way earlier than usual under their tiny feet.
Of five sites monitored in the Bellingshausen Sea region in 2023, all but one experienced a 100 percent loss of chicks, earlier research reported.
Unlike sea ice, ice sheets and the ice shelves to which they are connected are on -- or supported by -- land.
The world would need to heat up by five degrees Celsius compared with pre-industrial levels to melt the entire Antarctic ice sheet, which would lift global oceans an almost unimaginable 58 metres (nearly 200 feet).
Point of no return
But global warming to date -- on average about 1.3C -- is fast approaching a threshold that would cause part of the ice sheet to generate at least three metres of sea level rise, flooding coastal areas inhabited today by hundreds of millions, the study said.
'Unstoppable collapse of the West Antarctic Ice Sheet is one of the most concerning global tipping points,' said Abram.
'The evidence points to this being triggered at global warming well below 2C.'
Another potential risk is the collapse of the Antarctic Overturning Circulation, a system of ocean currents that distribute heat and nutrients within the the region and globally.
A 'rapid and substantial slowdown' of the currents has already begun, and evidence from the previous interglacial period -- between two ice ages -- before our own, 125,000 years ago, points to an abrupt stagnation of the system under conditions similar to those seen today.
'This would lead to widespread climate and ecosystem impacts,' ranging from an intensification of global warming to a decrease in the ocean's capacity to absorb CO2, the study reported.
Ultimately, the only way to slow down the interlocking changes is to stop adding more planet-warming gases into the atmosphere.
'The greenhouse gas emission decisions that we make over the coming decade or two will lock in how much ice we will lose and how quickly it will be lost,' Abram said.
By Marlowe Hood
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CTV News
4 hours ago
- CTV News
Surging tourism is polluting Antarctica, scientists warn
In this photo provided by Sea Shepherd, a whale swims near the krill trawler Fu Xing Hai with mountains of the Antarctic Peninsula in the background, on April 2, 2025. (Youenn Kerdavid/Sea Shepherd via AP) Soaring numbers of tourists and expanding research projects are increasingly polluting Antarctica, scientists warned Wednesday, a fresh blow for one of Earth's most pristine environments already threatened by human-driven climate change. In Antarctic areas where humans have been active, the concentration of fine particles containing heavy metals is 10 times higher than it was 40 years ago, the international team of researchers said in a new study. That change has come as the number of annual tourists visiting the white continent has risen from 20,000 to 120,000 over the last two decades, according to the International Association of Antarctica Tour Operators. 'The increasing human presence in Antarctica raises concerns about pollutants from fossil fuel combustion, including those from ships, aircraft, vehicles and supporting infrastructure,' the study in the journal Nature Sustainability said. Ships carrying tourists are powered by dirty fossil fuels, which are the source of fine particles containing things like nickel, copper, zinc and lead. 'Snow melts faster in Antarctica due to the presence of polluting particles in areas frequented by tourists,' study co-author Raul Cordero told AFP. 'A single tourist can contribute to accelerating the melting of around 100 tons of snow,' said the scientist at the University of Groningen in the Netherlands. The researchers -- from countries including Chile and Germany -- spent four years traveling 1,200 miles (2,000 kilometres) in Antarctica to measure the contamination. The presence of heavy metals has also increased due to scientific expeditions. Research projects that stay for an extended time can have up to 10 times more of an impact than a single tourist, Cordero said. The study acknowledged there have been 'meaningful steps forward' in attempts to protect Antarctica, such as a ban on highly polluting heavy fuel oil and the tourism industry embracing electric-hybrid ships. 'Nevertheless, our results show that more remains to be done to reduce the burdens of human activities in Antarctica,' including speeding up the transition to renewable energy and slashing fossil fuel use, the study said. A different Nature study also published on Wednesday warned that potentially irreversible changes in Antarctica driven by climate change could lift global oceans by meters and lead to 'catastrophic consequences for generations.'


CTV News
a day ago
- CTV News
Antarctic climate shifts threaten ‘catastrophic' impacts globally
Abrupt and potentially irreversible changes in Antarctica driven by climate change could lift global oceans by metres and lead to 'catastrophic consequences for generations', scientists warned Wednesday. More broadly, a state-of-knowledge review by a score of top experts revealed accelerating shifts across the region that are often both cause and effect of global warming, according to a study published in Nature. ADVERTISEMENT 'Antarctica is showing worrying signs of rapid change across its ice, ocean and ecosystems,' lead author and Australian National University professor Nerilie Abram told AFP. 'Some of these abrupt changes will be difficult to stop.' Shifts in different facets of Antarctica's climate system amplify each other and have accelerated the pace of warming globally as well, she said. The study looked at evidence of abrupt change -- or 'regime shifts' -- in sea ice, regional ocean currents, the continent's ice sheet and ice shelves, and marine life. It also examined how they interact. Floating sea ice does not add to sea level when it melts. But its retreat does replace white surfaces that reflect almost all of the Sun's energy back into space with deep blue water, which absorbs the same amount instead. Ninety percent of the heat generated by manmade global warming is soaked up by oceans. Retreating sea ice After increasing slightly during the first 35 years that satellite data was available, Antarctic sea ice cover plunged dramatically over the last decade. Since 2014, sea ice has retreated on average 120 kilometres (75 miles) from the continent's shoreline. That contraction has happened about three times faster in 10 years than the decline in Arctic sea ice over nearly 50. The 'overwhelming evidence of a regime shift in sea ice' means that, on current trends, Antarctica could essentially become ice free in summer sooner than the Arctic, the study found. This will speed up warming in the region and beyond, and could push some marine species toward extinction. Over the last two years, for example, helpless emperor penguin chicks perished at multiple breeding grounds, drowning or freezing to death when sea ice gave way earlier than usual under their tiny feet. Of five sites monitored in the Bellingshausen Sea region in 2023, all but one experienced a 100 percent loss of chicks, earlier research reported. Unlike sea ice, ice sheets and the ice shelves to which they are connected are on -- or supported by -- land. The world would need to heat up by five degrees Celsius compared with pre-industrial levels to melt the entire Antarctic ice sheet, which would lift global oceans an almost unimaginable 58 metres (nearly 200 feet). Point of no return But global warming to date -- on average about 1.3C -- is fast approaching a threshold that would cause part of the ice sheet to generate at least three metres of sea level rise, flooding coastal areas inhabited today by hundreds of millions, the study said. 'Unstoppable collapse of the West Antarctic Ice Sheet is one of the most concerning global tipping points,' said Abram. 'The evidence points to this being triggered at global warming well below 2C.' Another potential risk is the collapse of the Antarctic Overturning Circulation, a system of ocean currents that distribute heat and nutrients within the the region and globally. A 'rapid and substantial slowdown' of the currents has already begun, and evidence from the previous interglacial period -- between two ice ages -- before our own, 125,000 years ago, points to an abrupt stagnation of the system under conditions similar to those seen today. 'This would lead to widespread climate and ecosystem impacts,' ranging from an intensification of global warming to a decrease in the ocean's capacity to absorb CO2, the study reported. Ultimately, the only way to slow down the interlocking changes is to stop adding more planet-warming gases into the atmosphere. 'The greenhouse gas emission decisions that we make over the coming decade or two will lock in how much ice we will lose and how quickly it will be lost,' Abram said. By Marlowe Hood


Globe and Mail
2 days ago
- Globe and Mail
Gene Therapy Competitive Landscape Report 2025
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On 15 August 2025, Janssen Research & Development LLC organized a Phase 3 Follow-up Study of for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene. On 13 August 2025, REGENXBIO Inc. announced a phase I/II/III study to evaluate the safety, tolerability, pharmacodynamics (microdystrophin protein levels), pharmacokinetic, and clinical efficacy of RGX-202 when administered IV as one-time dose to ambulant male participants with Duchenne. A comprehensive, short-term, prophylactic immunosuppression regimen will be administered during treatment to mitigate a potential immune response. This study is being conducted in three sequential parts: a phase I/II study (Part 1), a phase 3 pivotal study (Part 2) and a confirmatory study (Part 3). Part 1 will study a one-time dose of RGX-202 (1x10^14 or 2x10^14 GC/kg) in up to 15 participants with Duchenne. 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Zolgensma Zolgensma (onasemnogene abeparvovec) is the only gene therapy for spinal muscular atrophy (SMA) and the only SMA treatment designed to directly address the genetic root cause of the disease by replacing the function of the missing or non-working SMN gene to halt disease progression through sustained SMN protein expression with a single, one-time IV infusion. Zolgensma was approved by the US Food and Drug Administration for the treatment of pediatric patients less than 2years of age with spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene. . Zolgensma is now approved in more than 40 countries and more than 2,000 patients have been treated with Zolgensma globally across clinical trials, managed access programs, and in the commercial setting. Spark Therapeutics Spark Therapeutics, is a fully integrated company committed to discovering, developing and delivering gene therapies, challenge the inevitability of genetic diseases, including blindness, hemophilia and neurodegenerative diseases. The company have successfully applied our technology in the first FDA-approved gene therapy in the U.S. for a genetic disease, and currently have three programs in clinical trials, including product candidates that have shown promising early results in patients with hemophilia. At Spark, there is the path to a world where no life is limited by genetic disease. LUXTURNA LUXTURNA is the first FDA-approved gene therapy for a genetic disease, the first and only pharmacologic treatment for an inherited retinal disease (IRD) and the first adeno-associated virus (AAV) vector gene therapy approved in the U.S. LUXTURNA was approved by FDA under Priority Review and previously received orphan drug and breakthrough therapy designations from FDA. 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DTX401 DTX401 is an investigational AAV8 gene therapy designed to deliver stable expression and activity of G6Pase-α using a single intravenous infusion. Long term Phase I/II data demonstrate an acceptable safety profile and durability of response. All treated patients have experienced stable or improved glucose control while tapering or discontinuing oral glucose replacement therapy with cornstarch after receiving DTX401. The Phase III GlucoGene study is underway to evaluate the ability of DTX401 to reduce the use of cornstarch while maintaining or improving glucose control as well as the therapy's impact on patients' quality of life. DTX401 was granted Orphan Drug Designation in the United States, EU and United Kingdom, and Regenerative Medicine Advanced Therapy (RMAT) designation and Fast Track designation in the United States. 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The drug is currently in Phase II stage of development for the treatment of patients with Fanconi Anemia (FA). Adverum Biotechnologies Adverum Biotechnologies is a clinical-stage gene therapy company targeting unmet medical needs in serious ocular and rare diseases. Adverum is evaluating its novel gene therapy candidate, ADVM-022, as a one-time, intravitreal injection for the treatment of patients with neovascular or wet age-related macular degeneration. ADVM-022 ADVM022 is being developed for the treatment of wet AMD. ADVM-022 utilizes a propriety vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette. Unlike other ophthalmic gene therapies that require a surgery to administer the gene therapy under the retina (sub-retinal approach) ADVM-022 has the advantage of being administered as a one-time IVT injection in the office and is designed to deliver long-term efficacy and reduce the burden of frequent anti-VEGF injections, optimize patient compliance, and improve vision outcomes for patients with wet AMD. The OPTIC trial is designed as a multi-center, open-label, dose-ranging, safety and efficacy trial of ADVM-022 in patients with wet AMD who have demonstrated responsiveness to anti-VEGF treatment. Patients in OPTIC are treatment experienced, and previously required frequent anti-VEGF injections to manage their wet AMD and to maintain functional vision. The drug is currently in Phase II stage of development for the treatment of patients with Wet AMD. Kyverna Therapeutics Kyverna is a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases. KYV-101 is advancing through clinical development across two broad areas of autoimmune disease: rheumatology and neurology, including two ongoing multi-center, open-label Phase I trials of KYV-101 in the United States and Germany for patients with lupus nephritis. Kyverna's pipeline includes next-generation chimeric antigen receptor (CAR) T-cell therapies in both autologous and allogeneic formats with properties intended to be well suited for use in B cell-driven autoimmune diseases. By advancing more than one mechanism for taming autoimmunity, Kyverna is positioned to act on its mission of transforming how autoimmune diseases are treated. KYV-101 KYV-101 is an autologous, fully human CD19 CAR T-cell product candidate for use in B cell-driven autoimmune diseases. The CAR in KYV-101 was designed by the National Institutes of Health (NIH) to improve tolerability and tested in a 20-patient Phase I trial in oncology. Results were published by the NIH in Nature Medicine. Kyverna is currently conducting trials of KYV-101 in patients with lupus nephritis, an autoimmune disease in which more than half of patients do not achieve a complete response to current therapies and are at risk of developing kidney failure. Additional clinical trials of KYV-101 in systemic sclerosis, and myasthenia gravis are in preparation. The drug is currently in Phase I/II stage of development for the treatment of patients with Lupus nephritis. Vivet Therapeutics Vivet Therapeutics is a private, clinical-stage biotech company developing novel and long-lasting gene therapies for rare inherited metabolic conditions, including Wilson's disease. Vivet's gene therapy platform uses recombinant adeno-associated viruses (rAAVs) as vectors and has initiated two clinical programs and four pre-clinical assets to date. Its most advanced therapy is VTX-801, a novel gene therapy for Wilson's disease, with key clinical read-outs expected by the end of 2024. Vivet Therapeutics was founded in 2016 by CEO Dr Jean-Philippe Combal and CSO Dr Gloria Gonzalez-Aseguinolaza and is led by a highly experienced management team with deep expertise developing gene therapies and orphan drugs. VTX-802 VTX-802 is an AAV-based gene therapy for patients with Progressive Familial Intrahepatic Cholestasis Type 2. It delivers a codon-optimized version of the BSEP gene to the liver and is currently under preclinical testing. The drug is currently in Preclinical stage of development for the treatment of patients with Intrahepatic cholestasis. Gene Therapy Analytical Perspective by DelveInsight In-depth Commercial Assessment: Gene Therapy Collaboration Analysis by Companies The Report provides in-depth commercial assessment of drugs that have been included, which comprises collaboration, agreement, licensing and acquisition – deals values trends. The sub-segmentation is described in the report which provide company-company collaboration (licensing/partnering), company academic collaboration and acquisition analysis in tabulated form. Gene Therapy Competitive Landscape The report comprises of comparative assessment of Companies (by therapy, development stage, and technology). Gene Therapy Report Assessment Company Analysis Therapeutic Assessment Pipeline Assessment Inactive drugs assessment Unmet Needs Transform your understanding of the Gene Therapy Pipeline! See the latest progress in drug development and clinical research @ Gene Therapy Market Drivers and Barriers, and Future Perspectives Scope of the Gene Therapy Competitive Landscape Report Coverage- Global Gene Therapy Companies- Pfizer, Ultragenyx Pharmaceutical Inc, Rocket Pharmaceuticals, Adverum Biotechnologies, Kyverna Therapeutics, Vivet Therapeutics, HELIXMITH Co, Rocket Pharmaceuticals, Bristol-Myers Squibb, Wellington Zhaotai Therapies, Reyon Pharmaceutical, Neowise Biotechnology, Orna Therapeutics, Genflow Biosciences, Xylocor Therapeutics, Kolon TissueGene, Allogene Therapeutics, Nanjing IASO Biotherapeutics, Shanghai Vitalgen BioPharma, Rui Therapeutics, Obsidian Therapeutics, YolTech Therapeutics, Neurotech USA, Beacon Therapeutics, REGENXBIO and others. Gene Therapy Analytical Perspective: In-depth Commercial Assessment Gene Therapy Unmet Needs, Preclinical and Discovery Stage Products Stay Ahead in Oncology Research–Access the Full Gene Therapy Pipeline Analysis Today! @ Gene Therapy Drugs and Companies Table of Contents Introduction Executive Summary Gene Therapy: Overview Gene Therapy -Analytical Perspective: In-depth Commercial Assessment Competitive Landscape Therapeutic Assessment Gene Therapy: Company and Product Profiles (Marketed Therapies) Novartis Zolgensma Gene Therapy: Company and Product Profiles (Pipeline Therapies) Late Stage Products (Phase III) Pfizer Fordadistrogene movaparvovec Mid Stage Products (Phase II) Rocket Pharmaceuticals RP-L102 Early Stage Products (Phase I/II) Kyverna Therapeutics KYV-101 Preclinical and Discovery Stage Products Vivet Therapeutics VTX-802 Inactive Products Gene Therapy- Unmet needs Gene Therapy – Market drivers and barriers Appendix About Us DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve. Media Contact Company Name: DelveInsight Business Research LLP Contact Person: Yash Bhardwaj Email: Send Email Phone: 09650213330 Address: 304 S. Jones Blvd #2432 City: Las Vegas State: NV Country: United States Website: