
Deborah loved geeky science and she would have been so proud of Bowelbabe lab, say family as unit is named in her honour
Last week the Stem Cell and Cancer Biology Lab at the Francis Crick Institute, near King's Cross station in London,
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Dame Deborah James' nickname is now etched on the door of one of Britain's leading cancer research labs
Credit: instagram/bowelbabe
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TV's Deborah died of bowel cancer in 2022
Credit: Instagram
Her brother Ben and sister Sarah Wieczorek took part in Sunday's London Marathon, both dressed as a poo, to raise money for the Bowelbabe Fund.
Ben, 34, told The Sun: 'Debs loved geeky science, especially this project where they are growing organoids and mini bowels.
'Whether it's cutting-edge research into personalised medicine or early detection, she loved it and she wanted to set up this fund to do exactly this.'
And Debs' husband, Seb Bowen told how she would have been 'unbelievably proud' to see the impact her Fund is having.
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READ MORE ON BOWEL CANCER
'Exciting but bittersweet'
He said: 'I felt so many emotions, but the overwhelming one was a sense of enormous pride at Deborah's fund being a part of this amazing, world-class institution.'
Sun columnist Dame Debs died from bowel cancer aged just 40 in 2022 but not before starting a massive charity and awareness movement to help save others from suffering the same fate.
Cash from her £17million legacy Bowelbabe Fund is now paying scientists on the frontline of bowel cancer research.
They are growing tiny organs in petri dishes and conducting DNA analysis to work out how to catch and treat the devastating disease.
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The Sun joined Debs' family last week for a tour of the facility with researchers, Cancer Research UK and the Health Secretary
Ben added: 'We've all enjoyed learning the science side of things. Like many families, you get into it when you are impacted by it.
Sun Health Explainer: Bowel Cancer
'Debs was fortunate enough to be with us for five years plus because of some of this research, and during that time she brought us into the loop and kept beating the drum for better awareness and understanding.
'It is always bittersweet but it's really exciting for the family to see that the money generously donated by the public is going to great use.'
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Bowel cancer is one of the most common types of tumour in the UK and the second biggest cancer killer.
Around 17,000 Brits die from the disease each year, fewer only than lung cancer which claims 35,000 lives.
Half of cases could be prevented with healthier living but many are harder to explain.
Scientists are particularly worried that the disease is becoming more common in young adults such as Debs, who was diagnosed aged just 35.
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Michelle Mitchell, chief executive of Cancer Research UK, said: 'Bowel cancer research is a significant priority for us. We are seeing a dramatic in- crease in early onset cancer around the world. We don't exactly know why yet, but that's why more research is absolutely critical.'
Dr Ian Walker, director of policy at the charity, added: 'The key thing for us is that we know if you detect bowel cancers early you have a significant change in your prognosis.
'Patients detected with very early stage bowel cancer have 90-plus per cent survival after five years.
'Whereas if you detect bowel cancer in the later stage of stage four that can be around only ten per cent.'
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Scientists working in the Bowelbabe lab, led by Dr Vivian Li, are studying early warning proteins in at-risk patients.
They hope to be able to detect chemical signals in blood or poo samples that could help with faster diagnosis of less common tumours.
Analysing genes that appear only in people with cancer could also help to develop early warning signs and provide targets for treatment.
A big focus for the team is the issue of chemotherapy resistance.
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This occurs when treatment stops working because a tumour gets used to the drugs being used to attack it.
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Debs' brother Ben poses next to the lab sign
Credit: Simon Jones
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Health Sec Wes Streeting meets Debs' parents Heather and Alistair
Credit: Simon Jones
Dr Li estimates this happens eventually in 90 per cent of patients with stage four cancer that has spread.
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She told The Sun: 'One of our recent findings is a gene called SOX2, which potentially contributes to chemotherapy resistance.
'That gene drives the cancer cell to go to sleep and the
'Now we're trying to revert that to sensitise the patient to chemotherapy.'
Dr Li's lab is also trying new approaches to immunotherapy, which harnesses the body's own immune system to attack cancer cells.
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They are able to test new treatment methods or genetic therapies on fascinating organoids in the lab.
Organoids are tiny human organs or tumours grown in petri dishes using cells harvested from patients.
They react just like the cells in the body parts doctors want to target, meaning researchers can test how different approaches might work in the clinic.
'Pushing the frontiers'
Supporting Dr Li's project was a no-brainer for Debs' family.
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Towards the end of her life, Dame Debs had an organoid of her own bowel tumour created, at the Institute of Cancer Research in London.
Deborah would've shared my pride, she would've found it all really, really exciting
Seb Bowen
She was also a regular visitor to laboratories including those at The Crick where she helped lift the curtain on the cutting-edge science giving so many cancer patients hope.
After being diagnosed in 2016, the former deputy head teacher made it her mission to raise awareness, dressing up in poo emojis to break taboos and urging people: 'Check your poo!'
FUND HIT £17M
THE BowelBabe Fund was set up in May 2022 after Debs revealed in her final Sun column she had returned to her parents' home to receive palliative care.
Dame Deborah made a final plea for people to help her hit £10million and, since her death, the fund soared to £17million.
The cash has funded projects – including a new X-ray machine at the Royal Marsden Hospital in Surrey, where she was treated, and a bowel cancer roadshow to raise awareness.
Most of the money is funding cutting edge cancer research, including new treatments, better testing, using AI for diagnosis and understanding how tumours spread.
If you would like to donate go to bowelbabe.org
She shared the signs and symptoms every one should know in her Sun column, Things Cancer Made Me Say, and called for action to invest in research to find new treatments.
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Deborah often said she was 'riding on the wings of science' — a reference to the fact new, cutting-edge treatments helped her survive for five-and-a-half years, when statistics suggested she might not live a year.
So seeing her name adorned on the door of a lab at The Crick was such a special moment for her family.
Her parents Heather and Alistair, told The Sun: 'Deborah would be over the moon to know that a lab dedicated to finding new treatments bears her name.'
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Ben, centre, and Seb Bowen meet Wes at the lab
Credit: Simon Jones
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Seb added: 'With talented scientists from around the world and CRUK, the UK is at the forefront of cancer research, and I'm not sure many people realise that.
'Deborah would've shared my pride, she would've found it all really, really exciting.
'To see money raised in her name helping fund projects that will hopefully one day help save lives, was exactly what she hoped for.
'It's inspiring to know the fund has the potential to have such a positive impact.'
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One of the reasons Dame Deborah's legacy is so impactful is that every time she's in The Sun or in the media, we see searches for bowel cancer symptoms going up and people going and getting tested
Wes Streeting
Her parents added: 'Deborah didn't want us all sitting around feeling sad, and in setting up the Bowelbabe Fund she ensured that we always have a really positive focus.
'She has, and continues to be, at the forefront of our minds when we decide on the projects to support — made easier by the fact we all know what she would've wanted. To know that she is still helping to save lives almost three years on, makes us all very proud.'
Wes Streeting, a cancer survivor himself, visited the lab last week with Debs' family.
He said: 'One of the reasons Dame Deborah's legacy is so impactful is that every time she's in The Sun or in the media, we see searches for bowel cancer symptoms going up and people going and getting tested.
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'The work that is now being done in her name and the fundraising that has taken place in her name — thanks to her amazing family — is pushing the frontiers of medical science in this area.
'That legacy lives on so it's entirely fitting that we've now got the Bowelbabe Lab here with Cancer Research UK at the Crick Institute.'
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Debs' husband, Seb told how she would've been 'unbelievably proud' to see the impact her Fund is having
Credit: Getty
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Deborah's nickname on the laboratory window
Credit: Simon Jones
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Ben with sister Sarah after running Sunday's London Marathon
Credit: Supplied
CHECK YOUR POO
DAME Debs told anyone who would listen to 'check your poo' in her crusade to raise awareness.
These are the most common signs of potential bowel cancer:
Poo becoming looser, harder, or diarrhoea or constipation that doesn't go away
Signs of red or black blood in the toilet
Needing to poo more or less often than usual
Bloating, feeling full or like you need to go when you don't
Tummy or lower back pain
An unexplained lump near your gut
Feeling tired all the time
Losing weight for no reason
If you are worried about any symptoms, speak to your GP.

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The Irish Sun
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Rise of ‘faux-zempic' fake weight loss drugs being imported into UK black market & sold on social media…how to spot dupe
Celeb Big Brother star Aisleyne Horgan-Wallace tells Sun Club readers she 'thought she was going to die' and even lost her eyesight after unknowingly taking fake weight-loss jabs FAKE JAB HELL Rise of 'faux-zempic' fake weight loss drugs being imported into UK black market & sold on social media…how to spot dupe WEIGHT-LOSS drugs can be a silver bullet for some trying to shed the pounds after years of failure with fad diets and exercise routines. But dodgy vendors selling potentially deadly fake jabs laced with everything from rat poison to cement have appeared on the black market - with murky labs in foreign countries fuelling the supply, experts have told The Sun. 16 Bags of fake Ozempic pens seized in a UK crackdown Credit: MHRA 16 Michelle Sword fell into a coma after using fake fat jabs - which turned out to be insulin Credit: Supplied 16 Aisleyne Horgan-Wallace thought she'd bagged herself a bargain after buying fat jabs through a WhatsApp group - but says she 'nearly died' Credit: aisleyne1/Instagram 16 Wegovy and Mounjaro are the licensed weight loss jabs in the UK Credit: Getty Celeb endorsements and gushing influencers have encouraged many people who can't get fat jabs prescribed by the NHS to look for Wegovy, Ozempic, and Mounjaro elsewhere. And some Brits have found out the hard way about the perils of gambling with fake drugs - which can contain a cocktail of poison, including cement and arsenic. One of those was Celeb Big Brother star Aisleyne Horgan-Wallace, who told The Sun she "thought she was going to die" and even lost her eyesight after unknowingly taking fake weight-loss jabs. She was left bedridden for three days, constantly vomiting and was unable to even walk to her en-suite toilet after injecting what she dubbed a "syringe of horror". Her crystal clear message to anyone thinking about buying weight-loss jabs from an unofficial source is: "Don't." So-called "skinny jabs" require a prescription from a qualified medic - and must be obtained from registered pharmacies. Ozempic is only licensed as a type 2 diabetes treatment in the UK, unlike in America, meaning the NHS cannot prescribe it for weight loss. Private doctors may be willing to prescribe it "off-label" for weight loss - but that exposes people to a higher risk of being duped, experts say. Meanwhile, Wegovy and Mounjaro can be prescribed on the NHS for weight loss - and may also be bought privately. Crucially, private purchases also need a prescription from a qualified medic - and online platforms are required to conduct a face-to-face or video consultation before dispensing the drugs. Towie star Saffron Lempriere reveals how she lost 12 pounds in 4 weeks - without fat jabs But in reality, jabs can be bought without prescriptions - widely available from social media or unlicensed websites posing as pharmacies flogging the stuff for less than half price at around £80. 'Dicing with death' Health chiefs warned last year that deadly fakes had reached the UK market - and broken into the legitimate supply chain. So far, over 100 deaths have been linked to weight loss drugs in the UK, according to recent data, and it's unclear if any deaths have been linked to fake jabs. But a leading GP who spoke to the BBC warned that those buying weight loss drugs online are "dicing with death". Counterfeits are often linked to organised crime groups, according to Anne Devaud, the head of product security at Novo Nordisk - the manufacturer of Ozempic and Wegovy. Anne told The Sun: "There are lots of sellers in Turkey using UK or French phone numbers to hide where the supply is really coming from. "The best way for these criminals to flog their wares is through social media - because that's where Brits naturally turn," she added. I can't believe that I allowed my insecurities to almost kill me Michelle Sword Groups in China are one of the primary sources for the fakes, Anne said, but the company has also identified counterfeit manufacturing in places like Turkey and Brazil. Anne said: "There are different sources of illicit manufacturing. "Some may order semaglutide from, for example, a Chinese supplier and then do their own stuff. "But another group might simply put starch or water inside - because the purpose is solely to make money." Real Ozempic and Wegovy jabs contain the active ingredient semaglutide, while Mounjaro uses a compound of the same chemical with another called tirzepatide. But fake pens can contain dangerously high doses of semaglutide, or different drugs entirely, like insulin, which can make people seriously sick if taken unnecessarily. Some online platforms also sell real products which have been shipped from overseas, where the same rigorous standards don't apply. Experts say that the rise of counterfeit drugs is a consequence of the supply struggling to keep up with demand - and imposter jabs present a range of perils. 16 Mum-of-two Michelle Sword managed to get hold of the fake jabs without any medical checks, and was told it could be delivered straight away Credit: David Hartley 16 Michelle said, 'I can't believe that I allowed my insecurities to almost kill me' Credit: Supplied 16 An original Ozempic pen, top, vs a counterfeit, bottom Credit: PA 16 Counterfeit semaglutide and Ozempic jabs seized in the US Credit: CNBC Toby Nicol, CEO at CheqUp, told The Sun: "The surge in popularity of weight loss injections has unfortunately created a lucrative opportunity for counterfeiters. "Fake weight loss drugs often originate from unregulated manufacturing operations, where oversight is minimal and quality control can be nonexistent - they are only interested in cash, not care. "These counterfeit products frequently enter the market through unauthorised online pharmacies or social media marketplaces that bypass regulation and rules. If it seems too good to be true, it probably is Toby Nicol "They come in one of two forms - either in pens which mimic those offered genuinely for Mounjaro and Wegovy or sold simply as some powder in a vial to which people add water. "This latter type is very common on TikTok where patients are encouraged to buy something, which could be chalk and inject it into themselves. "Anything which costs less than about £80 to £100 per month is probably fake." Toby warned: "If it seems too good to be true, it probably is." Rat poison, cement and arsenic Kevin Joshua, a weight-loss clinician, explained how the fakes sometimes contain insulin instead of semaglutide - which can lead to "critically low blood sugar, coma, or death". 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She tells The Sun that last year was "really tough" after she lost two very important people and her way of dealing with the pain was to "eat her feelings" - meaning she piled on almost two stone. When a friend suggested she tried Ozempic, Aisleyne rushed into it without considering the dangers, because she was in "such a bad place". She says: "I got added to a WhatsApp group where girls talk about what they want to have done - lip fillers and things - and someone on there was offering Ozempic. 16 Aisleyne Horgan Wallace says she 'nearly died' after injecting fake fat jabs Credit: Olivia West 16 Texts between Aisleyne and the person who organised her supply, about another friend who fell sick after using the injections Credit: supplied 16 Aisleyne's drugs came in an unbranded syringe Credit: supplied How to spot a fake MOST fakes are not completely identical to the authentic products, and there are some signs you can look out. According to Novo Nordisk, the manufacturer of Ozempic and Wegovy, these are the giveaways... Dodgy packaging : Fake jabs will often come in boxes and packaging of inferior quality. The graphics are more likely to look cheap or misaligned. : Fake jabs will often come in boxes and packaging of inferior quality. The graphics are more likely to look cheap or misaligned. Spelling errors : Text on the counterfeits are much more likely to contain spelling mistakes. : Text on the counterfeits are much more likely to contain spelling mistakes. Dose selector: The manufacturer says that some fakes have dose selectors which can be pulled out when dialled to a select dose. The selectors on the genuine product are fixed in place. The manufacturer says that some fakes have dose selectors which can be pulled out when dialled to a select dose. The selectors on the genuine product are fixed in place. Unbranded: Some counterfeits are completely unbranded, like the plain syringe Aisleyne received. The genuine products will always be branded with the company name and logo. However, it's important remember that some counterfeits will not bear any of those signs. The only way to guarantee a genuine product is to "obtain appropriate medicine on prescription through legitimate sources", Novo Nordisk advises. "With the first month's supply I felt fine, even energetic, and I could see that I was losing a bit of weight. "But then I took the second month's - and I came so close to death. I wish I never, ever took the first month's supply or even heard about this drug. "For three days I was in bed, literally comatose. I'd wake up, roll over and vomit into a bag. There were bags of vomit all around me. "I couldn't even walk the two steps to the en-suite toilet, I had to crawl and drag myself. "After a day I didn't need to go to the toilet because I wasn't eating or drinking - I couldn't even sip anything. "On day two, I opened my eyes and I couldn't see anything out of one of my eyes." The TV star to this day does not know what was in the jabs - but insists: "It was a syringe of horrors, that's all I know. The chemicals must have been wrong." 16 Wegovy is the UK version of Ozempic licensed for weight loss in the UK Credit: PA 16 Amy Schumer is one of the many high-profile celebs to admit she has used weight loss drugs 16 Gemma Collins also revealed she has been using fat jabs Credit: Many other women have got in touch with Aisleyne with similar accounts, proving the problem is widespread. Michelle Sword, 47, is another who nearly died after injecting herself with a fake Ozempic jab. She fell into a coma after administering the medicine, which turned out to be insulin. Michele said: "It was a lot harder to get hold of Ozempic, so I didn't go down the conventional way of doing it. "The beauty companies and the online aesthetic companies all seemed to have it." The mum-of-two managed to get hold of some without any medical checks, and was told it could be delivered straight away. But soon after injecting, she collapsed and began suffering seizures - and tests showed her blood sugar levels had plummeted and sent her into a diabetic coma. Michelle said: "I can't believe that I allowed my insecurities to almost kill me." Fat jab crisis In December 2024, the Royal Pharmaceutical Society warned that social media was fuelling such an appetite for weight-loss jabs that the supply simply couldn't keep up. It even likened the situation to the toilet paper shortages during the Covid pandemic. To keep up with demand, some NHS pharmacies could soon be given powers to prescribe the injections - cutting out the need for patients to see the GP. Addressing the unlicensed supply chain, it said: "These unregulated websites often specifically target those medicines that are in shortage. "These illegal sites come with the risk that patients may be accessing medicines that are outside of a rigorous, quality-controlled supply chain and may be unauthorised and/or falsified." Similarly, the National Pharmacy Association warned there could be a possible "explosion in the unlicensed sale of medication online". NPA chairman Nick Kaye said last year: 'Pharmacists remain deeply concerned that the current medicine shortages crisis could lead to an explosion in the unlicensed sale of medication online. 'Stocks of Ozempic are very depleted in community pharmacy in the UK and it is important that these remain prioritised for those in the most clinical need. 'Given the precarious state of supply of this and other vital medication, there is a much greater risk of people looking to order in supplies from disreputable online vendors." 16 Even if the product is branded as Ozempic it can be a fake - like this suspected counterfeit Credit: Reuters 16 The drugs can be injected into the skin of your stomach, thigh or arm Cracking down Novo Nordisk is the pharmaceutical company which manufactures Ozempic and Wegovy. Anne, head of product security, told The Sun that pharma companies are collaborating with each other and law enforcement agencies to counter the rise of counterfeit products. She said: "It's a long run, because we are fighting against organized crime. But I'm confident because now we have governance, we are sharing with other pharma companies and authorities. "The best ways to mitigate against the risks are two things: First is to litigate as much as possible and work with prosecutor in order to disrupt [the supply]. "The second is to continue to develop awareness - because everybody has a responsibility. "If patients are more vigilant, ordering less online, if we are collaborating with authorities, if also authorities are reinforcing regulation to avoid any illicit compounding to enter in the country, I'm quite confident that with this combined effort we may really make a difference, so there is no question mark for us. We are on it." Novo Nordisk urges anyone who believes they have hold of a fake pen to not use it. They are encouraged to report it to the Medicines and Healthcare Products Regulatory Agency - the body tasked with protecting the UK's drug supply. The MHRA said it has been seizing counterfeit Ozempic pens since 2023. Andy Morling, its deputy director of criminal enforcement, told CNBC last year: "We saw that the demand increased and quite often as it happens in these situations, criminals try and fill a gap where the supply and demand aren't balanced for a particular product, and we started seeing real counterfeit versions of the Ozempic product on the market."


The Irish Sun
3 days ago
- The Irish Sun
Holiday hotspots report cases of organ destroying virus sparking global outbreak fears in China
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