This blood test can predict heart attack risk, and it's not cholesterol
Heart attack risk
and why the
hs-CRP test
helps predict it early
C-reactive protein (CRP) is a substance produced by the liver in response to inflammation in the body. The high-sensitivity CRP (hs-CRP) test measures very low levels of CRP, helping detect chronic inflammation that may not cause obvious symptoms. Inflammation plays a central role in the development of atherosclerosis—a condition in which arteries become narrowed or blocked due to plaque buildup—raising the risk of heart attacks and strokes.
According to the
American Heart Association
(AHA), individuals with elevated hs-CRP levels, even if their cholesterol appears normal, may still face significantly higher cardiovascular risk.
Study confirms: hs-CRP predicts heart attack risk
A major study called the
JUPITER trial
, published in the New England Journal of Medicine in 2008, provided strong evidence that measuring hs-CRP levels can help identify people at risk for heart attacks—even if their cholesterol is normal.
In this large-scale study involving over 17,000 participants with normal LDL cholesterol but elevated hs-CRP levels, researchers found that treatment with a statin (rosuvastatin) cut the risk of heart attack by 54% and stroke by 48% compared to placebo.
This demonstrated that inflammation—not just cholesterol—plays a critical role in cardiovascular risk.
Interpreting hs-CRP levels and heart attack risk categories
According to guidelines, hs-CRP levels fall into three major risk categories:
<1.0 mg/L – Low cardiovascular risk
1.0–3.0 mg/L – Moderate risk
>3.0 mg/L – High risk
Even in the absence of high LDL cholesterol, values above 3.0 mg/L suggest a greater likelihood of vascular inflammation and arterial damage.
How to lower hs-CRP and reduce heart risk
Several lifestyle and medical interventions can help reduce hs-CRP levels:
Adopt an anti-inflammatory diet (rich in fruits, vegetables, whole grains, and omega-3s)
Exercise regularly (150+ minutes/week of moderate activity)
Quit smoking
Maintain a healthy weight
Consider statin therapy if advised by a physician—particularly if both cholesterol and CRP are high
Statins have been shown not only to lower LDL cholesterol but also to reduce inflammation markers like hs-CRP, as highlighted in the JUPITER trial.
Cholesterol is just one piece of the cardiovascular puzzle. Measuring hs-CRP provides insight into hidden inflammation, helping to identify individuals at risk for heart disease—even if their standard lipid panel looks normal. For a more comprehensive cardiovascular assessment, ask your healthcare provider about getting an hs-CRP test alongside traditional cholesterol and Lipoprotein(a) testing.
Also Read: Strength training for diabetes: How weight lifting helps manage type 2 diabetes
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
NDTV
a day ago
- NDTV
Study Says Too Much Sleep Might Be Bad For You, Here's How
In a recent analysis, scientists examined data from 79 previous studies that tracked individuals for at least a year to explore how sleep duration might influence the risk of poor health or death. They discovered that people who slept less than seven hours per night faced a 14% higher risk of death during the study period, compared to those who got between seven and eight hours of sleep. This finding aligns with the well-documented health consequences of inadequate sleep. Interestingly, the analysis also revealed that individuals who regularly slept more than nine hours a night had an even greater risk of dying 34% higher than those sleeping the recommended seven to eight hours. This finding is consistent with a 2018 study that pooled results from 74 other studies spanning one to 30 years. That research also found a 14% increase in death risk among people who slept more than nine hours. Other studies have linked excessive sleep more than what's typically recommended for one's age with various health concerns, including depression, chronic pain, weight gain, and metabolic disorders. While these findings may seem concerning, it's important to understand that these studies show a correlation between long sleep and health risks, not a direct cause-and-effect relationship. How sleeping too much can be bad for you 1. Increased risk of heart disease Oversleeping has been linked to a higher risk of cardiovascular issues, including heart attacks and stroke. Studies suggest that sleeping more than nine hours regularly may lead to changes in blood pressure and heart rate variability, both of which are critical factors for heart health. 2. Greater chance of depression Excessive sleep can be both a symptom and a contributor to depression. People who sleep more than the typical range often report low energy levels, reduced motivation, and feelings of sadness or worthlessness. The irregular sleep patterns that come with oversleeping can disrupt circadian rhythms and hormonal balance, worsening depressive symptoms over time. 3. Weight gain and obesity Sleeping too much may contribute to weight gain. Oversleeping can lead to a sedentary lifestyle, less physical activity, and poor eating habits. Additionally, long sleep durations may disrupt metabolism and hunger-regulating hormones like leptin and ghrelin, making it easier to gain weight unintentionally. 4. Chronic pain and inflammation While rest is essential for healing, oversleeping can actually worsen pain conditions such as back pain or arthritis. Staying in bed for too long can stiffen joints, strain muscles, and contribute to inflammation. Oversleeping is also associated with elevated levels of C-reactive protein (CRP), a marker of inflammation in the body. 5. Impaired brain function Excessive sleep can dull mental sharpness and slow cognitive performance. People who oversleep often report memory issues, poor concentration, and difficulty with decision-making. Over time, these effects can interfere with productivity, learning, and overall mental clarity. 6. Possible link to dementia Emerging research suggests a potential connection between prolonged sleep and cognitive decline in older adults. Longer sleep durations have been associated with structural changes in the brain and an increased risk of neurodegenerative conditions like dementia and Alzheimer's disease, although more research is needed to understand this link fully. While sleep is vital to health, balance is key. Regularly getting the right amount typically 7 to 9 hours for most adults is essential for physical, emotional, and mental well-being. Disclaimer: This content including advice provides generic information only. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.
Indian Express
2 days ago
- Indian Express
What happens to the body if you take a berberine supplement every day?
Berberine has often been likened to nature's Ozempic, highlighting its properties that aid in weight loss. This supplement might not be very popular in the health and wellness space, but it promises numerous beneficial effects on the body. spoke to health experts to find out whether it is safe for daily and long term use. 'Berberine, a natural compound found in plants like goldenseal and barberry, activates AMP-activated protein kinase (AMPK), an enzyme regulating energy metabolism. This leads to improved insulin sensitivity, enhanced glucose uptake, and reduced blood sugar levels,' said Dr Manish Joshi, Additional Director- Surgical Gastroenterology, Fortis Hospital, Bengaluru. Berberine also exhibits antimicrobial, anti-inflammatory, and antioxidant properties, supporting cardiovascular health by lowering cholesterol and triglycerides. He added that berberine may improve gut health, and enhance cognitive function. Umang Malhotra, clinical dietitian at Fitero, shared that berberine, widely used in traditional medicine, is a natural bioactive compound extracted from goldenseal, barberry, tree turmeric, oregon grape, and chinese goldthread. Berberine's ability to activate AMPK also supports fat loss by regulating the way the body processes energy. He shared that it inhibits fat storage, promotes fat breakdown, and can enhance metabolic rate, which helps in weight management. 'It significantly reduces inflammation by lowering pro-inflammatory cytokines and markers of inflammation such as C-reactive protein (CRP). Berberine inhibits the production of inflammatory molecules such as cytokines (e.g., TNF-α, IL-6) and decreases CRP levels, which are markers commonly elevated in chronic inflammatory conditions,' explained Malhotra. Dr Joshi shared that generally berberine supplements are considered safe when taken daily in recommended doses (500-1,500 mg). 'Human studies have shown minimal side effects, such as mild gastrointestinal upset, diarrhea, or abdominal pain. However, high doses (>2,000 mg) may increase risk of adverse effects.' He advised pregnant or breastfeeding women, those with kidney or liver disease, and those taking medications such as blood thinners and diabetes medicines to consult their healthcare provider before using berberine. This is important in order to monitor blood sugar, kidney function, and liver enzymes. Quality supplements from reputable manufacturers can ensure purity and potency. Malhotra added that berberine can cause some mild side effects, particularly if taken in high doses or for extended periods: • Gastrointestinal issues such as diarrhea, cramping, flatulence, or constipation. • Hypoglycemia (low blood sugar) if combined with other blood sugar-lowering medications. • Potential interactions with medications, especially those metabolized by the liver, as berberine can inhibit certain liver enzymes. Dr Joshi also mentioned that long-term use may interact with medications, such as blood thinners, and decrease their effectiveness. Berberine may also lower blood pressure, potentially exacerbating hypotension. And in some rare cases, berberine toxicity has been reported, characterized by nausea, vomiting, and respiratory problems, he added.
Time of India
5 days ago
- Time of India
Coconut oil vs olive oil: Which is better for heart health?
Walk down any health food aisle in the grocery store and you'll find bottles of different varieties of oil side by side, each flaunting health claims that promise a longer, better life. But when it comes to heart health, which of these trendy oils truly delivers? With so many cooking oils lining supermarket shelves, it's easy to get confused, especially when popular picks like coconut oil and olive oil claim several health benefits. T he answer lies not in marketing slogans, but in what science says, comparing their fat content, antioxidants, and long-term effects on your cardiovascular system. So, based on science-backed information, which one is better for your health? Olive oil Olive oil, particularly extra virgin olive oil (EVOO), has long been hailed as a cardiovascular champion due to its high levels of monounsaturated fats, antioxidants, and anti-inflammatory compounds. According to researchers from UC Davis and the American Heart Association, its rich content of oleic acid and polyphenols supports cardiovascular health, regulates blood pressure, reduces inflammation, and lowers the risk of diseases like type 2 diabetes and Alzheimer's. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like TV providers are furious: this gadget gives you access to all channels Techno Mag Learn More Undo Let's delve a little deeper. Rooted in the Mediterranean diet, which is consistently linked with lower rates of heart disease, one of EVOO's key ingredients is oleic acid, a monounsaturated fat that has been shown to reduce LDL (bad) cholesterol without affecting HDL (good) cholesterol. According to the American Heart Association , researchers found that those who ate more than half a tablespoon of olive oil each day had a 15% lower risk of having any kind of cardiovascular disease and a 21% lower risk of coronary heart disease. Replacing one teaspoon of butter, margarine, mayonnaise, or dairy fat with the same amount of olive oil lowered the risk of cardiovascular disease by 5% and coronary heart disease by 7%. Moreover, EVOO is rich in polyphenols, natural antioxidants that help reduce inflammation, improve blood vessel function, and protect LDL cholesterol from oxidative damage (a major trigger for atherosclerosis). Compounds like oleocanthal (acts like a natural ibuprofen, blocking enzymes that fuel inflammation), found only in extra virgin varieties, have even been compared to ibuprofen in their ability to reduce inflammation. A landmark 2013 study published in the New England Journal of Medicine found that people who consumed a Mediterranean diet rich in olive oil had a significantly lower risk of heart attack, stroke, and death from cardiovascular causes. Another study reveals that higher olive oil consumption correlates with lower risks of heart disease, stroke, and overall mortality, which are the key benefits of Mediterranean-style diets. Coconut oil Coconut oil, on the other hand, has gained popularity thanks to its high content of medium-chain triglycerides (MCTs), which, as per studies , are believed to be more easily metabolized by the liver and used as a quick energy source. While that may sound promising, the issue lies in the type of fat that coconut oil is mostly made of: saturated fat. Now, the saturated fat in coconut oil is typically 80–90%, with much of it being lauric and myristic acid. These fats increase both HDL ('good') and LDL ('bad') cholesterol. However, rising LDL remains a key risk factor for heart disease. A 2020 meta-analysis found that coconut oil raised LDL cholesterol levels more than unsaturated fats and vegetable oils, without clear evidence of long-term cardiovascular benefit, with no evidence of anti-inflammatory or blood sugar benefits. On the other hand, randomized trials provide mixed results. One BMJ Open study showed coconut oil didn't significantly raise LDL compared to olive oil, and even boosted HDL. However, the long-term benefits of coconut oil remain unclear. The American Heart Association has strongly advised against the use of coconut oil as a heart-healthy alternative. So while coconut oil may be better than trans fats or butter in limited quantities, it doesn't hold up against oils like EVOO when it comes to protecting your heart. Why olive oil is a clear winner Cholesterol control: A key advantage of olive oil lies in its fatty acid profile. EVOO is rich in monounsaturated fats, which lower LDL cholesterol and raise HDL cholesterol, striking a protective balance for the heart. EVOO also contains plant sterols and phenols that may interfere with cholesterol absorption and protect against oxidative damage. On the contrary, as per research , coconut oil elevates LDL significantly, by about 10 mg/dL or more, when compared to non-tropical oils. Stability under heat: When it comes to cooking, EVOO isn't just heart-healthy, it's heat-stable. Its phenolic compounds prevent degradation at high temperatures, making it a safer choice for sautéing and roasting than commonly believed. Meanwhile, coconut oil scores well in stability tests, but lacks the antioxidant protection EVOO offers, making it a poor choice in comparison to olive oil. Inflammation and beyond: Chronic inflammation is one of the silent drivers of heart disease. Olive oil's antioxidants and oleocanthal reduce inflammatory markers, supporting cardiovascular and mental health over the long term. Coconut oil, on the other hand, does not provide these anti-inflammatory compounds and may worsen inflammation by raising LDL. Which one to use in the kitchen? In terms of smoke point and cooking stability, both oils have their place: EVOO has a moderate smoke point (~375°F) and is excellent for sautéing, roasting, and salad dressings. Its antioxidants actually make it quite stable for most home cooking methods. It is ideal for dressing, drizzling, or low-to-medium heat cooking. Additionally, as EVOO is rich in heart-supportive fats and antioxidants, it makes it one of the healthiest pantry staples. However, consuming too much olive oil, despite its health benefits, can lead to weight gain, digestive issues, and potentially exacerbate inflammation. Additionally, the high fat content can upset the digestive system, causing discomfort like diarrhea, bloating, and flatulence. Coconut Oil, with a higher smoke point (~450°F for refined versions), is better suited for high-heat cooking and baking. It also has a strong flavor, which can be a plus or a minus depending on your dish. However, consuming too much coconut oil, which is high in saturated fat, can lead to increased levels of LDL (bad) cholesterol, potentially raising the risk of heart disease and stroke. It's also high in calories, and excessive intake without dietary adjustments could contribute to weight gain. Coconut oil is great for adding flavor to tropical, Asian, or baking recipes. Choose virgin or unrefined versions for better benefits, and limit intake to occasional use to avoid excess saturated fat. The final verdict? To sum it up in one line: use coconut oil sparingly, olive oil liberally. If heart health is your priority (as it should be), extra virgin olive oil should be your #1 choice. With decades of evidence supporting its ability to lower cholesterol, reduce inflammation, and decrease the risk of cardiovascular disease, EVOO is not just a kitchen staple; it's a medical recommendation. Coconut oil, on the other hand, while flavorful and trendy, should be seen more as an occasional indulgence than a daily go-to. If you enjoy the taste, use it on special occasions or maybe on weekend cooking. However, turning it into your daily cooking oil might not be in the best interest of your health. This article is for informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making changes to your diet or using any product for health purposes.
