Reds at Cubs Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for August 4
Chicago and Cincinnati meet for the third series of the season as the Cubs won two out of three both times. Lately, these NL Central squads are trending in different directions.
The Cubs have won three of the past four games, including a ninth inning walkoff in the last contest, while the Reds have dropped four of the last six. Cincinnati is coming off a nine-game home stand where they finished 5-4.
Let's dive into the matchup and find a sweat or two. We've got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Reds at Cubs
Date: Monday, August 4, 2025
Time: 8:05PM EST
Site: Wrigley Field
City: Chicago, IL
Network/Streaming: FDSNOH, MARQ
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Reds at the Cubs
The latest odds as of Monday:
Moneyline: Reds (+120), Cubs (-143)
Spread: Cubs -1.5
Total: 8.0 runs
Probable starting pitchers for Reds at Cubs
Pitching matchup for August 4, 2025: Nick Lodolo vs. Michael Soroka
Reds: Nick Lodolo, (8-6, 3.09 ERA)Last outing: 3.38 ERA, 2 Earned Runs Allowed, 6 Hits Allowed, 1 Walks, and 11 Strikeouts
Cubs: Michael Soroka, (3-8, 4.87 ERA)Last outing: 5.40 ERA, 2 Earned Runs Allowed, 4 Hits Allowed, 0 Walks, and 4 Strikeouts
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Expert picks & predictions for tonight's game between the Reds and the Cubs
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Monday's game between the Reds and the Cubs:
Moneyline: NBC Sports Bet is recommending a play on the Chicago Cubs on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Cincinnati Reds at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Reds at Cubs
Chicago is 4-2 against Cincinnati this season
The Cubs have a 15-4 record in series openers at home this season
The Cubs' last 6 matchups against NL Central teams have gone over the Total
Chicago is 3-1 in the last four games
Cincinnati is 2-4 in the past six games
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
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Jay Croucher (@croucherJD)
Drew Dinsick (@whale_capper)
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