5 skin symptoms of liver disease that you should never ignore, according to a Harvard expert
From yellowing of the eyes to persistent itching, these visible signs may point to deeper issues like cirrhosis or hepatitis. Early recognition and medical evaluation can make a critical difference. Here are five skin-related symptoms that may indicate liver trouble and should never be overlooked.
Liver disease warning: 5 skin signs that could signal serious trouble
1. Yellowing of the skin and eyes (jaundice)
One of the most classic and visible signs of liver dysfunction is jaundice. It occurs when the liver can't properly process bilirubin, a yellow pigment resulting from the breakdown of red blood cells.
The pigment accumulates in the blood and tissues, giving the skin and sclera (whites of the eyes) a yellow tint. Dr. Sethi stresses that jaundice should prompt immediate medical evaluation, as it can be a symptom of hepatitis, bile duct obstruction, or advanced liver disease.
2. Spider-like blood vessels on the skin (spider angiomas)
Spider angiomas are small, red, web-shaped clusters of dilated blood vessels, often appearing on the face, neck, upper arms, or chest. These are linked to elevated estrogen levels, which can rise when the liver is unable to properly metabolize hormones.
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Their presence—especially when numerous—may suggest cirrhosis or chronic liver dysfunction. According to medical literature, they are more common in people with alcoholic liver disease and pregnancy, but sudden onset should not be ignored.
3. Redness in the palms (palmar erythema)
Palmar erythema is a symptom marked by persistent redness on the palms, particularly at the base of the thumb and little finger. It results from altered blood flow and hormonal imbalance—especially excess estrogen—in chronic liver disease.
Dr. Sethi notes that this sign is often mistaken for irritation or heat exposure but could reflect liver stress if it appears without an obvious cause. This condition is commonly associated with cirrhosis, fatty liver disease, and autoimmune hepatitis.
4. Persistent, unexplained itching (pruritus)
Itching—especially intense at night and without a rash—is a lesser-known but important sign of liver dysfunction. It can result from accumulation of bile acids in the bloodstream, particularly in conditions like cholestasis or primary biliary cholangitis (PBC).
This type of itching usually affects the hands, feet, and limbs, and can be distressing. Dr. Sethi advises patients not to dismiss chronic itchiness, as it may point to early bile duct or liver pathology.
5. Dark patches on the skin (hyperpigmentation)
Unusual darkening or patchy discoloration of the skin—especially around the eyes, mouth, or underarms—can occur in people with chronic liver disease. This happens due to hormonal imbalances, insulin resistance, or elevated melanin associated with liver dysfunction.
Studies have noted hyperpigmentation in conditions like hemochromatosis, autoimmune liver disease, and non-alcoholic steatohepatitis (NASH).
If these dark patches are new or worsening, especially in combination with other symptoms, medical evaluation is warranted.
When to see a doctor
While these skin symptoms might seem minor at first glance, they can act as crucial early indicators of liver disease. Experts recommend maintaining liver health through a balanced diet, limiting alcohol, exercising regularly, and getting routine blood tests and imaging when appropriate. If you notice any of these signs—especially in combination—it's important to consult a healthcare provider. Early detection saves lives and can prevent irreversible liver damage.
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